Prof Qingzhong Xiao

Qingzhong Xiao
MD, PhD

Professor of Stem Cell and Cardiovascular Disease

The William Harvey Research Institute
Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/xiao-qingzhong-.html
ORCID

Research

Stem cell, Vascular cell biology, Vascular disease, Non-coding RNAs, Molecular biology, Vascular development

Cardiovascular Models

Interests

2D (primary vascular smooth muscle cells and endothelial cells) or 3D (vascular organoids) in vitro models and several animal models of vascular diseases (atherosclerosis, post-angioplasty restenosis, Aortic aneurysm & dissection, vascular calcification) to study the aetiologies & therapeutic interventions of vascular diseases.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Aneurysm Is Restricted by CD34+ Cell‐Formed Fibrous Collars Through the PDGFRb‐PI3K Axis
Wu H, Yang X, Chen T, Yu B, Chen M, Wang T, Jiang L, Zhang B, Zhou X, Cheng J, Chen K, Zhang T, Hu Y, Xu S, Lian J, Zhang H, Xiao Q, Ye H and Xu Q
Advanced Science, Wiley 
27-12-2024
Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole
Martinez CS, Zheng A and Xiao Q
Antioxidants, Mdpi vol. 13 (11) 
31-10-2024
NRF3-mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing Pitx2
Zheng A, Chen Q, Shi Z, Xu X, Yang M, Sun S, Wang L, Wang Y, Xiao Q and Zhang L
European Heart Journal, Oxford University Press (Oup) vol. 45 (Supplement_1) 
28-10-2024
An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W and Xiao Q
European Journal of Cell Biology, Elsevier vol. 103 (4) 
24-10-2024
Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip
Cheruku GR, Wilson CV, Raviendran S and Xiao Q
Organoids, Mdpi vol. 3 (3), 203-246.  
04-09-2024
The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis
Zhang Y, Guan Z, Gong H, Ni Z, Xiao Q, Guo X and Xu Q
Cardiology Discovery, Wolters Kluwer vol. 4 (3), 231-244.  
13-08-2024
BCL6B-dependent suppression of ETV2 hampers endothelial cell differentiation
Li Z, Wu W, Li Q, Heng X, Zhang W, Zhu Y, Chen L, Chen Z, Shen M, Ma N, Xiao Q and Yan Y
Stem Cell Research & Therapy, Springer Nature vol. 15 (1) 
29-07-2024
Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia
Tang Y, Wu J, Sun X, Tan S, Li W, Yin S, Liu L, Chen Y, Liu Y, Tan Q, Jiang Y, Yang W, Huang W, Weng C, Wu Q, Lu Y, Yuan H, Xiao Q, Chen AF, Xu Q, Billiar TR and Cai J
Cell Reports, Elsevier vol. 43 (5) 
01-05-2024
Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia
Niu K, Zhang C, Yang M, Maguire EM, Shi Z, Sun S, Wu J, Liu C, An W, Wang X, Gao S, Ge S and Xiao Q
Cardiovascular Research, Oxford University Press (Oup) vol. 120 (7), 796-810.  
18-03-2024
Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024)
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D, Shanahan C and Iskratsch T
Advanced Science, Wiley vol. 11 (9) 
01-03-2024
Atlas of Cell Repertoire Within Neointimal Lesions Is Metabolically Altered in Hypertensive Rats
Sun X, Wu J, Zhang X, Xie C, Wei H, Li P, Yang Y, Yuan H, Cai J, Xiao Q, Cheng J and Xu Q
Hypertension, Wolters Kluwer vol. 81 (4), 787-800.  
19-01-2024

2023

Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and transdifferentiation of vascular smooth muscle cells to foam cells
Iskratsch T, Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D and Shanahan C
Advanced Science, Wiley Open Access 
25-12-2023
Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity
Liu S, Fang C, Zhong C, Li J and Xiao Q
Cell Biology and Toxicology, Springer Nature vol. 39 (6), 2527-2549.  
27-10-2023
Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease
Sun X, Lu Y, Wu J, Wen Q, Li Z, Tang Y, Shi Y, He T, Liu L, Huang W, Weng C, Wu Q, Xiao Q, Yuan H, Xu Q and Cai J
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 43 (10), 1867-1886.  
17-08-2023
Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice
Yang M, Zhou X, Pearce SWA, Yang Z, Chen Q, Niu K, Liu C, Luo J, Li D, Shao Y, Zhang C, Chen D, Wu Q, Cutillas PR, Zhao L, Xiao Q and Zhang L
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 43 (10), 1900-1920.  
17-08-2023

2022

Updated Perspectives on Direct Vascular Cellular Reprogramming and Their Potential Applications in Tissue Engineered Vascular Grafts
Sellahewa SG, Li JY and Xiao Q
Journal of Functional Biomaterials, Mdpi vol. 14 (1) 
30-12-2022
Optimization of CRISPR–Cas system for clinical cancer therapy
Meng X, Wu T, Lou Q, Niu K, Jiang L, Xiao Q, Xu T and Zhang L
Bioengineering & Translational Medicine, Wiley vol. 8 (2) 
23-12-2022
Noncoding RNAs in Vascular Cell Biology and Restenosis
Efovi D and Xiao Q
Biology, Mdpi vol. 12 (1) 
22-12-2022
The Effect of Lymphangiogenesis in Transplant Arteriosclerosis
Chen K, Mou R, Zhu P, Xu X, Wang H, Jiang L, Hu Y, Hu X, Ma L, Xiao Q and Xu Q
Circulation, Wolters Kluwer vol. 147 (6), 482-497.  
14-12-2022
Mechanoregulation of vascular smooth muscle cells phenotype in atherosclerosis
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Zhou X, Xiao Q, Shanahan C, Yu C-H and Iskratsch T
Journal of Molecular and Cellular Cardiology, Elsevier vol. 173, 41-42.  
01-12-2022
The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis
Karamanavi E, McVey DG, van der Laan SW, Stanczyk PJ, Morris GE, Wang Y, Yang W, Chan K, Poston RN, Luo J, Zhou X, Gong P, Jones PD, Cao J, Kostogrys RB, Webb TR, Pasterkamp G, Yu H, Xiao Q, Greer PA, Stringer EJ, Samani NJ and Ye S
Circulation Research, Wolters Kluwer vol. 131 (12), 1004-1017.  
02-11-2022
Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine Model
Zhang C, Niu K, Ren M, Zhou X, Yang Z, Yang M, Wang X, Luo J, Shao Y, Chen D, Gao S, Ge S, Wu Q and Xiao Q
Cells, Mdpi vol. 11 (20) 
14-10-2022
Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury
Zhou K, Chen H, Wang X-Y, Xu Y-M, Liao Y-F, Qin Y-Y, Ge X-W, Zhang T-T, Fang Z-L, Fu B-B, Xiao Q-Z, Zhu F-Q, Chen S-R, Liu X-S, Luo Q-C and Gao S
Biomedicine & Pharmacotherapy, Elsevier vol. 155 
07-10-2022
Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction
Yang S, Wang C, Ruan C, Chen M, Cao R, Sheng L, Chang N, Xu T, Zhao P, Liu X, Zhu F, Xiao Q and Gao S
Cells, Mdpi vol. 11 (10) 
18-05-2022
Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching
Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T
Science Advances, American Association For The Advancement of Science 
15-04-2022
Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption
Yan Y, Xu Y, Yang X, Li Z, Niu K, Liu C, Zhao M, Xiao Q and Wu W
Oxidative Medicine and Cellular Longevity, Hindawi vol. 2022 (1) 
11-03-2022
Long-term exposure to copper induces mitochondria-mediated apoptosis in mouse hearts
Pan M, Cheng Z-W, Huang C-G, Ye Z-Q, Sun L-J, Chen H, Fu B-B, Zhou K, Fang Z-R, Wang Z-J, Xiao Q-Z, Liu X-S, Zhu F-Q and Gao S
Ecotoxicology and Environmental Safety, Elsevier vol. 234 
04-03-2022
Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice
Yao L, Hao Y, Wen G, Xiao Q, Wu P, Wang J and Liu J
Frontiers in Pharmacology, Frontiers vol. 13 
24-02-2022

2021

Neutrophil elastase promotes neointimal hyperplasia by targeting toll‐like receptor 4 (TLR4)–NF‐κB signalling
Yang M, Chen Q, Mei L, Wen G, An W, Zhou X, Niu K, Liu C, Ren M, Sun K, Xiao Q and Zhang L
British Journal of Pharmacology, Wiley vol. 178 (20), 4048-4068.  
06-07-2021
Pathological Bases and Clinical Application of Long Noncoding RNAs in Cardiovascular Diseases
Zhang C, Niu K, Lian P, Hu Y, Shuai Z, Gao S, Ge S, Xu T, Xiao Q and Chen Z
Hypertension (Dallas, Tex. : 1979) vol. 78 (1), 16-29.  
01-07-2021
Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation
Hu LL, Zou K, Chen Y, Wu LJ, Cao J, Xiong XY, Wang L, Cheng XS, Xiao QZ and Yang RQ
Molecular Medicine Reports, Spandidos Publications vol. 23 (5) 
01-05-2021
Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling
An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K, Luo J, Zhang C, Sun X, Poston R, Zhang L, Evans PC and Xiao Q
Cardiovascular Research, Oxford University Press (Oup) vol. 118 (2), 638-653.  
18-02-2021

2020

Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T
, Cold Spring Harbor Laboratory 
28-12-2020
miRNA‐200c‐3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts
Chen D, Zhang C, Chen J, Yang M, Afzal TA, An W, Maguire EM, He S, Luo J, Wang X, Zhao Y, Wu Q and Xiao Q
The Journal of Pathology, Wiley vol. 253 (2), 209-224.  
28-11-2020
miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia
He S, Yang F, Yang M, An W, Maguire EM, Chen Q, Xiao R, Wu W, Zhang L, Wang W and Xiao Q
Stem Cell Research & Therapy, Springer Nature vol. 11 (1) 
03-11-2020
Updated Perspectives On Vascular Cell Specification And Pluripotent Stem Cell-Derived Vascular Organoids For Studying Vasculopathies.
Liu C, Niu K and Xiao Q
Cardiovascular Research, Oxford University Press (Oup) 
02-11-2020
Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis.
Cai J, Deng J, Gu W, Ni Z, Liu Y, Kamra Y, Saxena A, Hu Y, Yuan H, Xiao Q, Lu Y and Xu Q
Circulation Research, American Heart Association 
21-07-2020
Noncoding RNAs in vascular smooth muscle cell function and neointimal hyperplasia
Maguire EM and Xiao Q
The Febs Journal, Wiley vol. 287 (24), 5260-5283.  
22-05-2020
Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis
Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR, Caulfield MJ, Samani NJ, Zhu J and Ye S
Atherosclerosis, Elsevier vol. 296, 11-17.  
21-01-2020

2019

Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection
Maguire EM, Pearce SWA, Xiao R, Oo AY and Xiao Q
Pharmaceuticals, Mdpi vol. 12 (3) 
06-08-2019
Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia.
Yang F, Chen Q, Yang M, Maguire EM, Yu X, He S, Xiao R, Wang CS, An W, Wu W, Zhou Y, Xiao Q and Zhang L
Cardiovasc Res 
07-03-2019
A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties
Liu S-S, Maguire EM, Bai Y-S, Huang L, Liu Y, Xu L, Fauzi I, Zhang S-Q, Xiao Q and Ma N-F
Molecular and Cellular Biology, Taylor & Francis vol. 39 (4), e00357-e00318.  
01-02-2019

2018

Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease
Maguire EM, Pearce SWA and Xiao Q
Vascular Pharmacology, Elsevier vol. 112, 54-71.  
14-08-2018
Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation
Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P, Pellegatta F, Grigore L, Da Dalt L, Annoni A, Gregori S, Xiao Q, Caruso D, Mitro N, Catapano AL, Marelli-Berg FM and Norata GD
Nature Communications, Springer Nature vol. 9 (1) 
06-08-2018
Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis.
Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M, Zhang L, Ye S, Nourshargh S and Xiao Q
J Am Heart Assoc vol. 7 (4) 
08-02-2018

2017

miR-22 Is a Novel Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation and Neointima Formation
Yang F, Chen Q, He S, Yang M, Maguire EM, An W, Afzal TA, Luong LA, Zhang L and Xiao Q
Circulation, Wolters Kluwer vol. 137 (17), 1824-1841.  
15-12-2017
Cbx3 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration and Neointima Formation.
Zhang C, Chen D, Margaret Maguire E, He S, Chen J, An W, Yang M, Adeel Afzal T, Anh Luong L, Zhang L, Lei H, Wu Q and Xiao Q
Cardiovascular Research, Oxford University Press (Oup) 
30-11-2017
The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S and Caulfield MJ
Human Molecular Genetics, Oxford University Press (Oup) vol. 27 (1), 199-210.  
10-10-2017
Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia.
Zhang L, Chen Q, An W, Yang F, Maguire EM, Chen D, Zhang C, Wen G, Yang M, Dai B, Luong LA, Zhu J, Xu Q and Xiao Q
Arterioscler Thromb Vasc Biol, American Heart Association/American Stroke Association vol. 37 (11), 2182-2194.  
14-09-2017
Differentiation and Application of Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells
Maguire EM, Xiao Q and Xu Q
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 37 (11), 2026-2037.  
31-08-2017
Reactive oxygen species: key regulators in vascular health and diseases
Chen Q, Wang Q, Zhu J, Xiao Q and Zhang L
British Journal of Pharmacology, Wiley vol. 175 (8), 1279-1292.  
11-07-2017
The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque
AHLUWALIA A
Proceedings of The National Academy of Sciences of Usa, National Academy of Sciences 
02-01-2017

2016

NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia.
Afzal TA, Luong LA, Chen D, Zhang C, Yang F, Chen Q, An W, Wilkes E, Yashiro K, Cutillas PR, Zhang L and Xiao Q
Journal of The American Heart Association, Wiley vol. 5 (12), e004629-e004629.  
07-12-2016
[OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield MJ
 
01-09-2016
Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction
Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R, Wu J, Yan S, Situ H, He X, Chen Y, Tan X, Xiao Q, Tucker AT, Caulfield MJ and Ye S
, Editors: Humphries SE. Plos Genetics, Public Library of Science vol. 12 (7), e1006127-e1006127.  
07-07-2016
Functional role of miRNA-34A in smooth muscle cell functions and neointima formation
Yang F, Chen Q, Wen G, Zhang C, Luong LA, Zhu J, Zhang L and Xiao Q
Atherosclerosis, Elsevier vol. 244, e3-e4.  
01-01-2016

2015

miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration
Chen Q, Yang F, Guo M, Wen G, Zhang C, Luong LA, Zhu J, Xiao Q and Zhang L
Journal of Molecular and Cellular Cardiology, Elsevier vol. 89 (Pt A), 75-86.  
19-10-2015
Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M
Hypertension, Wolters Kluwer vol. 66 (suppl_1) 
01-09-2015
XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y and Xu Q
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (10), 2134-2144.  
27-08-2015
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J, Ye S, Xu Q, Wang W and Xiao Q
Cell Death and Differentiation vol. 22 (7), 1170-1180.  
01-07-2015
A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization*
Wen G, Zhang C, Chen Q, Luong LA, Mustafa A, Ye S and Xiao Q
Journal of Biological Chemistry, Elsevier vol. 290 (31), 19158-19172.  
19-06-2015
MicroRNA-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells by Targeting Methyl CpG-Binding Protein 2
Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong LA, Zhu J, Shu Y, Zhang L and Xiao Q
Arteriosclerosis Thrombosis and Vascular Biology vol. 35 (4), 918-929.  
01-01-2015
Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M
 
01-01-2015

2014

Matrix metalloproteinase-8 (MMP8) modulates M2 macrophage polarization and molecular mechanisms involved
Wen G, Chen Q, Luong LA, Mustafa A, Shu Y and Xiao Q
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG binding protein 2
Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong LA, Zhu J, Shu Y, Zhang L and Xiao Q
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation.
Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q and Ye S
Arterioscler Thromb Vasc Biol vol. 34 (1), 90-98.  
01-01-2014

2013

Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2.
Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z, Yin X, Mayr M, Cockerill G, Li JY-S, Chien S, Hu Y and Xu Q
J Biol Chem vol. 288 (44), 31853-31866.  
01-11-2013
MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1.
Luo Z, Wen G, Wang G, Pu X, Ye S, Xu Q, Wang W and Xiao Q
Stem Cells vol. 31 (9), 1749-1762.  
01-09-2013
Abstract 004: Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2
Zhao H, Huang Y, Yu X, Wen G, Wang W, Ye S and Xiao Q
Circulation Research, Wolters Kluwer vol. 113 (suppl_1) 
01-08-2013
Matrix metalloproteinases: Inflammatory regulators of cell behaviors in vascular formation and remodeling
Chen Q, Jin M, Yang F, Zhu J, Xiao Q and Zhang L
Mediators of Inflammation vol. 2013 
19-07-2013
An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo.
Fang C, Wen G, Zhang L, Lin L, Moore A, Wu S, Ye S and Xiao Q
Cardiovasc Res vol. 99 (1), 146-155.  
01-07-2013
Functional involvements of heterogeneous nuclear ribonucleoprotein A1 in smooth muscle differentiation from stem cells in vitro and in vivo.
Huang Y, Lin L, Yu X, Wen G, Pu X, Zhao H, Fang C, Zhu J, Ye S, Zhang L and Xiao Q
Stem Cells vol. 31 (5), 906-917.  
01-05-2013
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Yi-Shuan Li J, Chien S, Hu Y and Xu Q
Circulation vol. 127 (16), 1712-1722.  
23-04-2013
ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant.
Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S
Am J Hum Genet vol. 92 (3), 366-374.  
07-03-2013
ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant
Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S
American Journal of Human Genetics vol. 92 (3), 366-374.  
07-03-2013
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q and Zeng L
Journal of Biological Chemistry vol. 288 (2), 859-872.  
11-01-2013
Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions.
Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S
Circ Res vol. 112 (1), 35-47.  
04-01-2013
Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB
Zheng X, Wu Y, Zhu L, Chen Q, Zhou Y, Yan H, Chen T, Xiao Q, Zhu J and Zhang L
Differentiation vol. 85 (1-2), 41-54.  
01-01-2013
Reactive Oxygen Species in Vascular Formation and Development
Zhou Y, Yan H, Guo M, Zhu J, Xiao Q and Zhang L
Oxidative Medicine and Cellular Longevity vol. 2013 
01-01-2013
Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation
Chen Q, Jin M, Zhu J, Xiao Q and Zhang L
Biomed Research International vol. 2013 
01-01-2013

2012

Abstract 18700: Accelerated Endothelial Regeneration and Survival Attenuate Vein Graft Atherosclerosis via Terahydrobiopterin-Dependent eNOS Coupling
Ali ZA, Rinze R, Antoniades C, Douglas G, Hu Y, Xiao Q, Greaves D, Alp N, Xu Q and Channon K
Circulation, Wolters Kluwer vol. 126 (suppl_21) 
20-11-2012
Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.
Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ and Ye S
Hum Mol Genet vol. 21 (18), 4021-4029.  
15-09-2012
Contribution of stem cells to neointimal formation of decellularized vessel grafts in a novel mouse model
Tsai TN, Kirton JP, Campagnolo P, Zhang L, Xiao Q, Zhang Z, Wang W, Hu Y and Xu Q
American Journal of Pathology vol. 181 (1), 362-373.  
01-07-2012
Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells.
Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y, Ye S and Xu Q
Arterioscler Thromb Vasc Biol vol. 32 (3), 730-744.  
01-03-2012
Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells
Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y, Ye S and Xu Q
Arteriosclerosis, Thrombosis, and Vascular Biology vol. 32 (3), 730-744.  
01-03-2012
Influence of matrix metalloproteinase-12 on fibrinogen level.
Motterle A, Xiao Q, Kiechl S, Pender SLF, Morris GE, Willeit J, Caulfield MJ and Ye S
Atherosclerosis vol. 220 (2), 351-354.  
01-02-2012
Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis.
Wang G, Xiao Q, Luo Z, Ye S and Xu Q
J Biol Chem vol. 287 (4), 2896-2906.  
20-01-2012
Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis
Wang G, Xiao Q, Luo Z, Ye S and Xu Q
J Biol Chem. vol. 287 (4), 2896-2906.  
20-01-2012
Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on system to system mode
Liang Q-L, Liang X-P, Wang Y-M, Xie Y-Y, Zhang R-L, Chen X, Gao R, Cheng Y-J, Wu J, Xu Q-B, Xiao Q-Z, Li X, Lv S-F, Fan X-M, Zhang H-Y, Zhang Q-L and Luo G-A
Journal of Translational Medicine vol. 10 
01-01-2012
Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies
Knoflach M, Kiechl S, Mantovani A, Cuccovillo I, Bottazzi B, Xu Q, Xiao Q, Gasperi A, Mayr A, Kehrer M, Willeit J and Wick G
Plos One vol. 7 (2) 
01-01-2012
Functional Involvements of Heterogeneous Nuclear Ribonucleoprotein A1 in Smooth Muscle Differentiation from Stem Cells in vitro and in vivo
Huang Y, Lin L, Yu X, Pu X, Zhu J, Zhang L, Ye S and Xiao Q
Circulation vol. 126 (21) 
01-01-2012
Microrna-34a Regulates Smooth Muscle Cell Differentiation from Stem Cells by 'Targeting Sirtnin 1
Zhang L, Zheng X, Wu Y, Chen Q, Zhu J and Xiao Q
Circulation vol. 126 (21) 
01-01-2012
Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi
Luo Z, Wen G, Wang G, Pu X, Wang W, Ye S, Xu Q and Xiao Q
Circulation vol. 126 (21) 
01-01-2012
Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation
Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q and Ye S
Circulation vol. 126 (21) 
01-01-2012
A Functional Role of Matrix Metalloproteinase-8 in Stem/progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions
Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S
Circulation vol. 126 (21) 
01-01-2012

2011

Smooth Muscle Cell Differentiation from Embryonic Stem Cells: Role of HDAC7 and PDGF-BB
Sims D and Xiao Q
In Stem Cells and Cancer Stem Cells, Volume 4, Springer Nature 67-76.  
24-12-2011
Association of variation at the ABO locus with circulating levels of soluble intercellular adhesion molecule-1, soluble P-selectin, and soluble E-selectin: a meta-analysis.
Kiechl S, Paré G, Barbalic M, Qi L, Dupuis J, Dehghan A, Bis JC, Laxton RC, Xiao Q, Bonora E, Willeit J, Xu Q, Witteman JCM, Chasman D, Tracy RP, Ballantyne CM, Ridker PM, Benjamin EJ and Ye S
Circ Cardiovasc Genet vol. 4 (6), 681-686.  
01-12-2011
Splicing of histone deacetylase 7 modulates smooth muscle cell proliferation and neointima formation through nuclear β-catenin translocation.
Zhou B, Margariti A, Zeng L, Habi O, Xiao Q, Martin D, Wang G, Hu Y, Wang X and Xu Q
Arterioscler Thromb Vasc Biol vol. 31 (11), 2676-2684.  
01-11-2011
DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TOWARDS THE ENDOTHELIAL LINEAGE INVOLVES MICRORNAS
Luo Z, Xiao Q, Wang W and Xu Q
Heart vol. 97 (20), 4-4.  
01-10-2011
Chromobox protein homolog 3 is essential for stem cell differentiation to smooth muscles in vitro and in embryonic arteriogenesis.
Xiao Q, Wang G, Yin X, Luo Z, Margariti A, Zeng L, Mayr M, Ye S and Xu Q
Arterioscler Thromb Vasc Biol vol. 31 (8), 1842-1852.  
01-08-2011
Signalling pathways that regulate endothelial differentiation from stem cells
Luo ZL, Wang G, Wang W, Xiao QZ and Xu QB
Front Biosci-Landmrk vol. 16, 472-485.  
01-01-2011
STEM CELL DIFFERENTIATION TO SMOOTH MUSCLE CELLS IS REGULATED BY HNRNP A2/B1
Wang G, Xiao Q and Xu Q
Heart vol. 97 (20), 3-4.  
01-01-2011
Pluripotent Stem Cell Differentiation into Vascular Cells: A Novel Technology with Promises for Vascular Re(Generation)
Kane NM, Xiao Q, Baker AH, Luo Z, Xu Q and Emanueli C
Pharmacol Ther. vol. 129 (1), 29-49.  
01-01-2011
The genetics of epigenetics: is there a link with cardiovascular disease.
Xiao Q and Ye S
Heart vol. 97 (2), 96-97.  
01-01-2011

2010

Sp1-dependent activation of HDAC7 is required for platelet-derived growth factor-BB-induced smooth muscle cell differentiation from stem cells.
Zhang L, Jin M, Margariti A, Wang G, Luo Z, Zampetaki A, Zeng L, Ye S, Zhu J and Xiao Q
J Biol Chem vol. 285 (49), 38463-38472.  
03-12-2010
Coronary artery disease-related genetic variant on chromosome 10q11 is associated with carotid intima-media thickness and atherosclerosis.
Kiechl S, Laxton RC, Xiao Q, Hernesniemi JA, Raitakari OT, Kähönen M, Mayosi BM, Jula A, Moilanen L, Willeit J, Watkins H, Samani NJ, Lehtimäki TJ, Keavney B, Xu Q and Ye S
Arterioscler Thromb Vasc Biol vol. 30 (12), 2678-2683.  
01-12-2010
Sp1-dependent activation of HDAC7 is required for PDGF-BB-induced smooth muscle cell differentiation from stem cells
Zhang L, Jin M, Margariti A, Wang G, Luo Z, Zampetaki A, Zeng L, Ye S, Zhu J and Xiao Q
The Journal of Biological Chemistry vol. 285, 38463-38472.  
01-10-2010
The mechanism of stem cell differentiation into smooth muscle cells.
xiao Q, Wang G, Luo Z and Xu Q
Thromb Haemost vol. 104 (3), 440-448.  
01-09-2010
BAS/BSCR43 X-box binding protein 1 splicing is crucial in endothelial cell proliferation
Zeng L, Xiao Q, Li H, Margariti A, Hu Y and Xu Q
Heart, Bmj vol. 96 (17) 
26-08-2010
BAS/BSCR30 Crucial roles of Cbx3 identified by nuclear proteomics in smooth muscle differentiation from stem cells and vascular injury-induced neointima formation
Xiao Q, Wang G, Bai X, Yin X, Luo Z, Mayr M, Ye S and Xu Q
Heart, Bmj vol. 96 (17) 
26-08-2010
Histone deacetylase 7 controls endothelial cell growth through modulation of beta-catenin
Margariti A, Zampetaki A, Xiao Q, Zou B, Karamariti E, Martin D, Yin X, Mayr M, Li H and Zhang Z
Circ Res. vol. 106 (7), 1202-1211.  
16-04-2010
Crucial role of nrf3 in smooth muscle cell differentiation from stem cells
Pepe AE, Xiao Q, Zampetaki A, Zhang Z, Kobayashi A, Hu Y and Xu Q
Circ Res. vol. 106 (5), 870-879.  
19-03-2010
Single nucleotide polymorphism on chromosome 9p21 and endothelial progenitor cells in a general population cohort.
Ye S, Willeit J, Xiao Q, Motterle A, Laxton RC, Oberhollenzer F, Kiechl S and Xu Q
Atherosclerosis vol. 208 (2), 451-455.  
01-02-2010
A Role of Matrix Metalloproteinase-8 in Atherosclerosis: Correction

Circulation Research, Wolters Kluwer vol. 106 (1) 
08-01-2010
Histone deacetylase 3 is critical in endothelial survival and atherosclerosis development in response to disturbed flow
Zampetaki A, Zeng L, Margariti A, Xiao Q, Li H, Zhang Z, Pepe AE, Wang G, Habi O, deFalco E, Cockerill G, Mason JC, Hu Y and Xu Q
Circulation vol. 121 (1), 132-142.  
05-01-2010
Xbp1 Splicing is Crucial in Endothelial Cell Proliferation
Zeng L, Xiao Q, Li H, Margariti A, Hu Y and Xu Q
Circulation vol. 122 (21) 
01-01-2010
Pla2g7 is Crucial in Stem Cell Differentiation into Smooth Muscle Cells and Involves in Atherosclerosis
Xiao Q, Pepe AE and Xu Q
Circulation vol. 122 (21) 
01-01-2010
X-Box Binding Protein 1 Splicing Triggers an Autophagic Response-Mediated Survival in Endothelial Cells
Margariti A, Li H, Martin D, Xiao Q, Zampetaki A, Hu Y, Xu Q and Zeng L
Circulation vol. 122 (21) 
01-01-2010
Bone Marrow Resident and Circulating Progenitor Cells in Patients Undergoing Cardiac Surgery
Dotsenko O, Xiao Q, Xu Q and Jahangiri M
Annals of Thoracic Surgery vol. 90 (6), 1944-1951.  
01-01-2010

2009

Abstract 5474: Crucial Role of Nrf3 in Smooth Muscle Cell Differentiation From Stem Cells and Vessel Injury-Induced Neointima Formation
Pepe AE, Xiao Q, Zampetaki A, Hu Y and Xu Q
Circulation, Wolters Kluwer vol. 120 (suppl_18) 
03-11-2009
Abstract 5444: Cbx3 Identified by Nuclear Proteomics Plays a Key Role in Stem Cell Differentiation Into Smooth Muscle Cells in vitro and in vivo
Xiao Q, Wang G, Bai X, Yin X, Mayr M, Wang X and Xu Q
Circulation, Wolters Kluwer vol. 120 (suppl_18) 
03-11-2009
A role of matrix metalloproteinase-8 in atherosclerosis.
Laxton RC, Hu Y, Duchene J, Zhang F, Zhang Z, Leung K-Y, Xiao Q, Scotland RS, Hodgkinson CP, Smith K, Willeit J, López-Otín C, Simpson IA, Kiechl S, Ahluwalia A, Xu Q and Ye S
Circ Res vol. 105 (9), 921-929.  
23-10-2009
Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C and Willeit J
Blood vol. 114 (3), 723-732.  
16-07-2009
Abstract: P224 SEVERITY OF CORONARY ATHEROSCLEROSIS AND CARDIOPULMONARY BYPASS AFFECT STEM CELL TRAFFICKING FOLLOWING CARDIAC SURGERY
Dotsenko O, Xiao Q, Xu Q and Jahangiri M
Atherosclerosis Plus, Elsevier vol. 10 (2) 
01-06-2009
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow
Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG and Cockerill G
Proc Natl Acad Sci U S a. vol. 106 (20), 8326-8331.  
19-05-2009
Caspase-8, a double-edged sword for EPC functioning
Xiao Q and Xu Q
Arterioscler Thromb Vasc Biol. vol. 29 (4), 444-446.  
01-04-2009
Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2
Xiao Q, Luo Z, Pepe AE, Margariti A, Zeng L and Xu Q
Am J Physiol Cell Physiol. vol. 296 (4), C711-C723.  
01-04-2009
Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells
Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Martin D, Hu Y, Zeng L and Xu Q
J Cell Sci. vol. 122 (4), 460-470.  
15-02-2009
Proteomics identifies thymidine phosphorylase as a key regulator of the angiogenic potential of colony-forming units and endothelial progenitor cell cultures.
Pula G, Mayr U, Evans C, Prokopi M, Vara DS, Yin X, Astroulakis Z, Xiao Q, Hill J and Xu Q
Circ Res. vol. 104 (1), 32-40.  
02-01-2009
Endothelial progenitor cells and pregnancy REPLY
Xiao Q, Savvidou MD and Nicolaides KH
American Journal of Obstetrics and Gynecology vol. 200 (1), E19-E20.  
01-01-2009
NUCLEAR FACTOR ERYTHROID 2-RELATED FACTOR 3 MEDIATES STEM CELL DIFFERENTIATION INTO SMOOTH MUSCLE CELLS THROUGH INCREASED REACTIVE OXYGEN SPECIES GENERATION AND PLASMA PHOSPHOLIPASE A2 PRODUCTION
Pepe AE, Xiao Q, Zampetaki A and Xu Q
Heart vol. 95 (22) 
01-01-2009
Splicing of HDAC7 modulates the SRF-myocardin complex during stem-cell differentiation towards smooth muscle cells
Margariti A, Xiao Q, Zampetaki A, Zhang Z, Li H, Martin D, Hu Y, Zeng L and Xu Q
Journal of Cell Science vol. 122 (4), 460-470.  
01-01-2009
NADPH OXIDASE PRODUCED HYDROGEN PEROXIDE-MEDIATED SMOOTH MUSCLE CELL DIFFERENTIATION FROM STEM CELL
Xiao Q, Luo Z, Pepe A, Margariti A, Zeng L and Xu Q
Heart vol. 95 (22) 
01-01-2009
SEVERITY OF CORONARY ATHEROSCLEROSIS AND CARDIOPULMONARY BYPASS AFFECT STEM CELL TRAFFICKING FOLLOWING CARDIAC SURGERY
Dotsenko O, Xiao Q, Xu Q and Jahangiri M
Atherosclerosis Supplements vol. 10 (2) 
01-01-2009
PROTEOMICS IDENTIFIES THYMIDINE PHOSPHORYLASE AS A KEY REGULATOR OF THE ANGIOGENIC POTENTIAL OF COLONY FORMING UNITS AND ENDOTHELIAL PROGENITOR CELL CULTURES
Mayr U, Pula G, Evans C, Prokopi M, Yin X, Xiao Q, Hill J, Xu Q and Mayr M
Heart vol. 95 (22) 
01-01-2009
Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures
Prokopi M, Pula G, Mayr U, Devue C, Gallagher J, Xiao Q, Boulanger CM, Westwood N, Urbich C, Willeit J, Steiner M, Breuss J, Xu Q, Kiechl S and Mayr M
Blood vol. 114 (3), 723-732.  
01-01-2009
P4.12 Egress of Functionally Competent Progenitor Cells Over-Expressing Cxcr4 From the Bone Marrow Following Cardiac Surgery with the Use of Cardiopulmonary Bypass
Dotsenko O, Xiao Q, Xu Q and Jahangiri M
Artery Research, Springer Nature vol. 3 (4), 173-173.  
01-01-2009

2008

SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study
Xiao Q, Ye S, Oberhollenzer F, Mayr A, Jahangiri M, Willeit J, Kiechl S and Xu Q
Plos One vol. 3 (12) 
30-12-2008
Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice
Foteinos G, Hu Y, Xiao Q, Metzler B and Xu Q
Circulation vol. 117 (14), 1856-1863.  
08-04-2008
Maternal circulating endothelial progenitor cells in normal singleton and twin pregnancy
Savvidou MD, Xiao Q, Kaihura C, Anderson JM and Nicolaides KH
Am J Obstet Gynecol. vol. 198 (4), 414.e1-414.e5.  
01-04-2008
Rapid endothelial turnover in atherosclerosis-prone areas coincides with stem cell repair in apolipoprotein E-deficient mice
Foteinos G, Hu Y, Xiao Q, Metzler B and Xu Q
Circulation vol. 117 (14), 1856-1863.  
01-01-2008
Nox4 is Crucial for Stem Cell Differentiation into Smooth Muscle Cells
Xiao Q, Zhang L, Luo Z, Pepe A, Margariti A, Zeng L and Xu Q
Circulation vol. 118 (18), S411-S411.  
01-01-2008
Proteomics Identifies Thymidine Phosphorylase as a Key Regulator of the Angiogenic Potential of Endothelial Progenitor Cells
Pula G, Mayr U, Evans C, Prokopi M, Xiao Q, Hill J, Xu Q and Mayr M
Circulation vol. 118 (18), S412-S412.  
01-01-2008
SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number: the Bruneck Study.
Xiao Q, Ye S, Oberhollenzer F, Mayr A, Jahangiri M, Willeit J, Kiechl S and Xu Q
Plos One vol. 3 (12) 
01-01-2008

2007

Vascular progenitor cells and atherosclerosis
Adams B, Xiao Q and Xu Q
Future Cardiology, Taylor & Francis vol. 3 (6), 635-645.  
01-11-2007
Changes of endothelial progenitor cells and vascular endothelial growth factor in patients with coronary artery disease
Qi XW, Liu HF, Xue YZ, Kong XQ, Xu QB and Xiao QZ
Journal of Clinical Rehabilitative Tissue Engineering Research vol. 11 (42), 8439-8443.  
21-10-2007
Abstract 433: HDAC7 is Essential for Stem Cell Differentiation into Smooth Muscle Cells
Margariti A, Xiao Q, Zampetaki A, Hu Y, Zeng L and Xu Q
Circulation, Wolters Kluwer vol. 116 (suppl_16) 
16-10-2007
Integrated membrane protein analysis of mature and embryonic stem cell-derived smooth muscle cells using a novel combination of CyDye/biotin labeling.
Sidibe A, Yin X, Tarelli E, Xiao Q, Zampetaki A, Xu Q and Mayr M
Mol Cell Proteomics vol. 6 (10), 1788-1797.  
01-10-2007
Endothelial Progenitor Cells are Mobilized After Cardiac Surgery
Roberts N, Xiao Q, Weir G, Xu Q and Jahangiri M
The Annals of Thoracic Surgery, Elsevier vol. 83 (2), 598-605.  
01-02-2007
Endothelial Progenitor Cells, Cardiovascular Risk Factors, Cytokine Levels and Atherosclerosis - Results from a Large Population-Based Study
Xiao Q, Kiechl S, Patel S, Oberhollenzer F, Weger S, Mayr A, Metzler B, Reindl M, Hu Y, Willeit J and Xu Q
Plos One vol. 2 (10) 
01-01-2007
Stem cell therapy for vascular disease
Adams B, Xiao Q and Xu Q
Trends in Cardiovascular Medicine vol. 17 (7), 246-251.  
01-01-2007
Lacking cytokine production in ES cells and ES-cell-derived vascular cells stimulated by TNF-α is rescued by HDAC inhibitor trichostatin A
Zampetaki A, Zeng L, Xiao Q, Margariti A, Hu Y and Xu Q
American Journal of Physiology-Cell Physiology vol. 293 (4), C1226-C1238.  
01-01-2007

2006

Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells
Yin XK, Mayr M, Xiao QZ, Wang W and Xu QB
Proteomics vol. 6 (24), 6437-6446.  
01-12-2006
HDAC3 is crucial in shear- and VEGF-induced stem cell differentiation toward endothelial cells
Zeng L, Xiao Q, Margariti A, Zhang Z, Zampetaki A, Patel S, Capogrossi MC, Hu Y and Xu Q
Journal of Cell Biology, Rockefeller University Press vol. 174 (7), 1059-1069.  
18-09-2006
Proteomic analysis of embryonic stem cell-derived smooth muscle cells
Yin X, Xiao Q, Mayr U, Mayr M and Xu Q
Vascular Pharmacology, Elsevier vol. 45 (3) 
01-09-2006
Shear stress-induced stem cell differentiation toward endothelial cells is regulated by HDAC-P53-P21 pathways
Zeng L, Xiao Q, Margariti A and Xu Q
Vascular Pharmacology, Elsevier vol. 45 (3) 
01-09-2006
TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications
Zampetaki A, Xiao Q, Zeng L and Xu Q
Vascular Pharmacology, Elsevier vol. 45 (3) 
01-09-2006
Stem cell-derived Sca-1+ progenitors differentiate into smooth muscle cells, which is mediated by collagen IV-integrin α1/β1/αv and PDGF receptor pathways
Xiao Q, Zeng L, Zhang Z, Hu Y and Xu Q
American Journal of Physiology - Cell Physiology, American Physiological Society vol. 292 (1), c342-c352.  
16-08-2006
Sca-1+ Progenitors Derived From Embryonic Stem Cells Differentiate Into Endothelial Cells Capable of Vascular Repair After Arterial Injury
Xiao Q, Zeng L, Zhang Z, Margariti A, Ali ZA, Channon KM, Xu Q and Hu Y
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 26 (10), 2244-2251.  
10-08-2006
TLR4 expression in mouse embryonic stem cells and in stem cell-derived vascular cells is regulated by epigenetic modifications
Zampetaki A, Xiao Q, Zeng L, Hu Y and Xu Q
Biochemical and Biophysical Research Communications, Elsevier vol. 347 (1), 89-99.  
19-06-2006

2005

Association of serum-soluble heat shock protein 60 with carotid atherosclerosis: clinical significance determined in a follow-up study
XIAO Q, Mandal K, Schett G, Mayr M, Wick G, Oberhollenzer F, Willeit J, Kiechl S and XU Q
Stroke, Lippincott Williams & Wilkins vol. 36 (12), 2571-2576.  
27-10-2005
Chinese herbs for inducing differentiation of mesenchymal stem cells in rats
Dong XX, Liu JB, Dong YX, He HH, Dong WH, Liang ZP and Xiao QZ
Chinese Journal of Clinical Rehabilitation vol. 9 (9), 210-212.  
01-03-2005
[Distribution and drug-resistance of 3 500 gram-negative bacteria in Guangzhou].
Xiao Q-Z, Su D-H, Jiang J-H and Zhong N-S
Journal of Southern Medical University vol. 25 (2), 132-138.  
01-02-2005
Proteomic dataset of Sca-1+ progenitor cells
WANG W, Yin XK, Xu QB, Wait R, Mayr U, Mayr M, Xiao QZ and Tarelli E
Proteomics vol. 5 (17), 4533-4545.  
01-01-2005

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconA Novel role for CD34+ Cell-derived Fibroblasts in Abdominal Aortic Aneurysm
Qingzhong Xiao and Qingbo Xu
£346,749 BHF British Heart Foundation
01-11-2023 - 25-02-2027
bullet iconEndothelial Repair by CD34+ Stem/Progenitor Cells in Atherosclerosis
Qingzhong Xiao and Qingbo Xu
£304,530 BHF British Heart Foundation
19-07-2021 - 05-09-2025

bullet iconFunctional roles of hnRNPA1 in vascular smooth muscle cell phenotype modulation and neointima hyperplasis
Qingzhong Xiao
£244,031 BHF British Heart Foundation
01-08-2017 - 31-07-2018
bullet iconA novel role of Cezanne in vascular smooth muscle cell proliferation and neoinima hyperplasia
Qingzhong Xiao
£228,758 BHF British Heart Foundation
01-02-2016 - 20-06-2019
bullet iconDTP 2015
Qingzhong Xiao
£49,950 MRC Medical Research Council
01-10-2015 - 30-09-2018