Prof Qingzhong Xiao
Professor of Stem Cell and Cardiovascular Disease
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Stem cell, Vascular cell biology, Vascular disease, Non-coding RNAs, Molecular biology, Vascular development
Interests
2D (primary vascular smooth muscle cells and endothelial cells) or 3D (vascular organoids) in vitro models and several animal models of vascular diseases (atherosclerosis, post-angioplasty restenosis, Aortic aneurysm & dissection, vascular calcification) to study the aetiologies & therapeutic interventions of vascular diseases.Publications
Publications of specific relevance to Predictive in vitro Models2024
Martinez CS, Zheng A and Xiao Q (2024). Mitochondrial Reactive Oxygen Species Dysregulation in Heart Failure with Preserved Ejection Fraction: A Fraction of the Whole. MDPI Antioxidants vol. 13, (11) Zheng A, Chen Q, Shi Z, Xu X, Yang M, Sun S, Wang L, Wang Y, Xiao Q and Zhang L (2024). NRF3-mediated mitochondrial superoxide promotes cardiomyocyte apoptosis and impairs cardiac functions by suppressing Pitx2. Oxford University Press (OUP) European Heart Journal vol. 45, (Supplement_1) Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W and Xiao Q (2024). An Unexpected Role of IL10 in Mesoderm Induction and Differentiation from Pluripotent Stem Cells: Implications in Zebrafish Angiogenic Sprouting, Vascular Organoid Development, and Therapeutic Angiogenesis. Elsevier European Journal of Cell Biology Cheruku GR, Wilson CV, Raviendran S and Xiao Q (2024). Recent Advances and Future Perspectives in Vascular Organoids and Vessel-on-Chip. MDPI Organoids vol. 3, (3) 203-246. Zhang Y, Guan Z, Gong H, Ni Z, Xiao Q, Guo X and Xu Q (2024). The Role of Progenitor Cells in the Pathogenesis of Arteriosclerosis. Wolters Kluwer Cardiology Discovery vol. 4, (3) 231-244. Li Z, Wu W, Li Q, Heng X, Zhang W, Zhu Y, Chen L, Chen Z, Shen M, Ma N, Xiao Q and Yan Y (2024). BCL6B-dependent suppression of ETV2 hampers endothelial cell differentiation. Springer Nature Stem Cell Research & Therapy vol. 15, (1) Tang Y, Wu J, Sun X, Tan S, Li W, Yin S, Liu L, Chen Y, Liu Y, Tan Q, Jiang Y, Yang W, Huang W, Weng C, Wu Q, Lu Y, Yuan H, Xiao Q, Chen AF, Xu Q, Billiar TR and Cai J (2024). Cardiolipin oxidized by ROS from complex II acts as a target of gasdermin D to drive mitochondrial pore and heart dysfunction in endotoxemia. Elsevier Cell Reports vol. 43, (5) Niu K, Zhang C, Yang M, Maguire EM, Shi Z, Sun S, Wu J, Liu C, An W, Wang X, Gao S, Ge S and Xiao Q (2024). Small nucleolar RNA host gene 18 controls vascular smooth muscle cell contractile phenotype and neointimal hyperplasia. Oxford University Press (OUP) Cardiovascular Research vol. 120, (7) 796-810. 
Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D, Shanahan C and Iskratsch T (2024). Hypertensive Pressure Mechanosensing Alone Triggers Lipid Droplet Accumulation and Transdifferentiation of Vascular Smooth Muscle Cells to Foam Cells (Adv. Sci. 9/2024). Wiley Advanced Science vol. 11, (9) Sun X, Wu J, Zhang X, Xie C, Wei H, Li P, Yang Y, Yuan H, Cai J, Xiao Q, Cheng J and Xu Q (2024). Atlas of Cell Repertoire Within Neointimal Lesions Is Metabolically Altered in Hypertensive Rats. Wolters Kluwer Hypertension vol. 81, (4) 787-800. 2023
Iskratsch T, Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D and Shanahan C (2023). Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and
transdifferentiation of vascular smooth muscle cells to foam cells. Wiley Open Access Advanced Science Liu S, Fang C, Zhong C, Li J and Xiao Q (2023). Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity. Springer Nature Cell Biology and Toxicology vol. 39, (6) 2527-2549. Sun X, Lu Y, Wu J, Wen Q, Li Z, Tang Y, Shi Y, He T, Liu L, Huang W, Weng C, Wu Q, Xiao Q, Yuan H, Xu Q and Cai J (2023). Meta-Analysis of Single-Cell RNA-Seq Data Reveals the Mechanism of Formation and Heterogeneity of Tertiary Lymphoid Organ in Vascular Disease. Wolters Kluwer Arteriosclerosis Thrombosis and Vascular Biology vol. 43, (10) 1867-1886. Yang M, Zhou X, Pearce SWA, Yang Z, Chen Q, Niu K, Liu C, Luo J, Li D, Shao Y, Zhang C, Chen D, Wu Q, Cutillas PR, Zhao L, Xiao Q and Zhang L (2023). Causal Role for Neutrophil Elastase in Thoracic Aortic Dissection in Mice. Wolters Kluwer Arteriosclerosis Thrombosis and Vascular Biology vol. 43, (10) 1900-1920. 2022
Sellahewa SG, Li JY and Xiao Q (2022). Updated Perspectives on Direct Vascular Cellular Reprogramming and Their Potential Applications in Tissue Engineered Vascular Grafts. MDPI Journal of Functional Biomaterials vol. 14, (1) Meng X, Wu T, Lou Q, Niu K, Jiang L, Xiao Q, Xu T and Zhang L (2022). Optimization of CRISPR–Cas system for clinical cancer therapy. Wiley Bioengineering & Translational Medicine vol. 8, (2) Efovi D and Xiao Q (2022). Noncoding RNAs in Vascular Cell Biology and Restenosis. MDPI Biology vol. 12, (1) Chen K, Mou R, Zhu P, Xu X, Wang H, Jiang L, Hu Y, Hu X, Ma L, Xiao Q and Xu Q (2022). The Effect of Lymphangiogenesis in Transplant Arteriosclerosis. Wolters Kluwer Circulation vol. 147, (6) 482-497. Swiatlowska P, Sit B, Feng Z, Marhuenda E, Zhou X, Xiao Q, Shanahan C, Yu C-H and Iskratsch T (2022). Mechanoregulation of vascular smooth muscle cells phenotype in atherosclerosis. Elsevier Journal of Molecular and Cellular Cardiology vol. 173, 41-42. Karamanavi E, McVey DG, van der Laan SW, Stanczyk PJ, Morris GE, Wang Y, Yang W, Chan K, Poston RN, Luo J, Zhou X, Gong P, Jones PD, Cao J, Kostogrys RB, Webb TR, Pasterkamp G, Yu H, Xiao Q, Greer PA, Stringer EJ, Samani NJ and Ye S (2022). The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis. Wolters Kluwer Circulation Research vol. 131, (12) 1004-1017. Zhang C, Niu K, Ren M, Zhou X, Yang Z, Yang M, Wang X, Luo J, Shao Y, Chen D, Gao S, Ge S, Wu Q and Xiao Q (2022). Targeted Inhibition of Matrix Metalloproteinase-8 Prevents Aortic Dissection in a Murine Model. MDPI Cells vol. 11, (20) Zhou K, Chen H, Wang X-Y, Xu Y-M, Liao Y-F, Qin Y-Y, Ge X-W, Zhang T-T, Fang Z-L, Fu B-B, Xiao Q-Z, Zhu F-Q, Chen S-R, Liu X-S, Luo Q-C and Gao S (2022). Targeted pharmacokinetics and bioinformatics screening strategy reveals JAK2 as the main target for Xin-Ji-Er-Kang in treatment of MIR injury. Elsevier Biomedicine & Pharmacotherapy vol. 155, Yang S, Wang C, Ruan C, Chen M, Cao R, Sheng L, Chang N, Xu T, Zhao P, Liu X, Zhu F, Xiao Q and Gao S (2022). Novel Insights into the Cardioprotective Effects of Calcitriol in Myocardial Infarction. MDPI Cells vol. 11, (10) Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2022). Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. American Association for the Advancement of Science Science Advances Yan Y, Xu Y, Yang X, Li Z, Niu K, Liu C, Zhao M, Xiao Q and Wu W (2022). Electron Transfer Flavoprotein (ETF) α Controls Blood Vessel Development by Regulating Endothelial Mitochondrial Bioenergetics and Oxygen Consumption. Hindawi Oxidative Medicine and Cellular Longevity vol. 2022, (1) Pan M, Cheng Z-W, Huang C-G, Ye Z-Q, Sun L-J, Chen H, Fu B-B, Zhou K, Fang Z-R, Wang Z-J, Xiao Q-Z, Liu X-S, Zhu F-Q and Gao S (2022). Long-term exposure to copper induces mitochondria-mediated apoptosis in mouse hearts. Elsevier Ecotoxicology and Environmental Safety vol. 234, Yao L, Hao Y, Wen G, Xiao Q, Wu P, Wang J and Liu J (2022). Induction of Heme Oxygenase-1 Modifies the Systemic Immunity and Reduces Atherosclerotic Lesion Development in ApoE Deficient Mice. Frontiers Frontiers in Pharmacology vol. 13, 2021
Yang M, Chen Q, Mei L, Wen G, An W, Zhou X, Niu K, Liu C, Ren M, Sun K, Xiao Q and Zhang L (2021). Neutrophil elastase promotes neointimal hyperplasia by targeting toll‐like receptor 4 (TLR4)–NF‐κB signalling. Wiley British Journal of Pharmacology vol. 178, (20) 4048-4068. Zhang C, Niu K, Lian P, Hu Y, Shuai Z, Gao S, Ge S, Xu T, Xiao Q and Chen Z (2021). Pathological Bases and Clinical Application of Long Noncoding RNAs in Cardiovascular Diseases. Hypertension (Dallas, Tex. : 1979) vol. 78, (1) 16-29. Hu LL, Zou K, Chen Y, Wu LJ, Cao J, Xiong XY, Wang L, Cheng XS, Xiao QZ and Yang RQ (2021). Functional role and molecular mechanisms underlying prohibitin 2 in platelet mitophagy and activation. Spandidos Publications Molecular Medicine Reports vol. 23, (5) An W, Luong LA, Bowden NP, Yang M, Wu W, Zhou X, Liu C, Niu K, Luo J, Zhang C, Sun X, Poston R, Zhang L, Evans PC and Xiao Q (2021). Cezanne is a critical regulator of pathological arterial remodelling by targeting β-catenin signalling. Oxford University Press (OUP) Cardiovascular Research vol. 118, (2) 638-653. 2020
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T (2020). Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching. Cold Spring Harbor Laboratory Chen D, Zhang C, Chen J, Yang M, Afzal TA, An W, Maguire EM, He S, Luo J, Wang X, Zhao Y, Wu Q and Xiao Q (2020). miRNA‐200c‐3p promotes endothelial to mesenchymal transition and neointimal hyperplasia in artery bypass grafts. Wiley The Journal of Pathology vol. 253, (2) 209-224. He S, Yang F, Yang M, An W, Maguire EM, Chen Q, Xiao R, Wu W, Zhang L, Wang W and Xiao Q (2020). miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia. Springer Nature Stem Cell Research & Therapy vol. 11, (1) Liu C, Niu K and Xiao Q (2020). Updated Perspectives On Vascular Cell Specification And Pluripotent Stem Cell-Derived Vascular Organoids For Studying Vasculopathies. Oxford University Press (OUP) Cardiovascular Research Cai J, Deng J, Gu W, Ni Z, Liu Y, Kamra Y, Saxena A, Hu Y, Yuan H, Xiao Q, Lu Y and Xu Q (2020). Impact of Local Allo-Immunity and Recipient Cells in Transplant Arteriosclerosis. American Heart Association Circulation Research Maguire EM and Xiao Q (2020). Noncoding RNAs in vascular smooth muscle cell function and neointimal hyperplasia. Wiley The FEBS Journal vol. 287, (24) 5260-5283. Pu X, Chan K, Yang W, Xiao Q, Zhang L, Moore AD, Liu C, Webb TR, Caulfield MJ, Samani NJ, Zhu J and Ye S (2020). Effect of a coronary-heart-disease-associated variant of ADAMTS7 on endothelial cell angiogenesis. Elsevier Atherosclerosis vol. 296, 11-17. 2019
Maguire EM, Pearce SWA, Xiao R, Oo AY and Xiao Q (2019). Matrix Metalloproteinase in Abdominal Aortic Aneurysm and Aortic Dissection. MDPI Pharmaceuticals vol. 12, (3) Yang F, Chen Q, Yang M, Maguire EM, Yu X, He S, Xiao R, Wang CS, An W, Wu W, Zhou Y, Xiao Q and Zhang L (2019). Macrophage-derived MMP-8 determines smooth muscle cell differentiation from adventitia stem/progenitor cells and promotes neointima hyperplasia. Cardiovasc Res Liu S-S, Maguire EM, Bai Y-S, Huang L, Liu Y, Xu L, Fauzi I, Zhang S-Q, Xiao Q and Ma N-F (2019). A Novel Regulatory Axis, CHD1L-MicroRNA 486-Matrix Metalloproteinase 2, Controls Spermatogonial Stem Cell Properties. Taylor & Francis Molecular and Cellular Biology vol. 39, (4) e00357-e00318. 2018
Maguire EM, Pearce SWA and Xiao Q (2018). Foam cell formation: A new target for fighting atherosclerosis and cardiovascular disease. Elsevier Vascular Pharmacology vol. 112, 54-71. Bonacina F, Coe D, Wang G, Longhi MP, Baragetti A, Moregola A, Garlaschelli K, Uboldi P, Pellegatta F, Grigore L, Da Dalt L, Annoni A, Gregori S, Xiao Q, Caruso D, Mitro N, Catapano AL, Marelli-Berg FM and Norata GD (2018). Myeloid apolipoprotein E controls dendritic cell antigen presentation and T cell activation. Springer Nature Nature Communications vol. 9, (1) Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M, Zhang L, Ye S, Nourshargh S and Xiao Q (2018). Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis. J Am Heart Assoc vol. 7, (4) 2017
Yang F, Chen Q, He S, Yang M, Maguire EM, An W, Afzal TA, Luong LA, Zhang L and Xiao Q (2017). miR-22 Is a Novel Mediator of Vascular Smooth Muscle Cell Phenotypic Modulation and Neointima Formation. Wolters Kluwer Circulation vol. 137, (17) 1824-1841. Zhang C, Chen D, Margaret Maguire E, He S, Chen J, An W, Yang M, Adeel Afzal T, Anh Luong L, Zhang L, Lei H, Wu Q and Xiao Q (2017). Cbx3 Inhibits Vascular Smooth Muscle Cell Proliferation, Migration and Neointima Formation. Oxford University Press (OUP) Cardiovascular Research Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S and Caulfield MJ (2017). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Oxford University Press (OUP) Human Molecular Genetics vol. 27, (1) 199-210. Zhang L, Chen Q, An W, Yang F, Maguire EM, Chen D, Zhang C, Wen G, Yang M, Dai B, Luong LA, Zhu J, Xu Q and Xiao Q (2017). Novel Pathological Role of hnRNPA1 (Heterogeneous Nuclear Ribonucleoprotein A1) in Vascular Smooth Muscle Cell Function and Neointima Hyperplasia. American Heart Association/American Stroke Association Arterioscler Thromb Vasc Biol vol. 37, (11) 2182-2194. Maguire EM, Xiao Q and Xu Q (2017). Differentiation and Application of Induced Pluripotent Stem Cell–Derived Vascular Smooth Muscle Cells. Wolters Kluwer Arteriosclerosis Thrombosis and Vascular Biology vol. 37, (11) 2026-2037. Chen Q, Wang Q, Zhu J, Xiao Q and Zhang L (2017). Reactive oxygen species: key regulators in vascular health and diseases. Wiley British Journal of Pharmacology vol. 175, (8) 1279-1292. AHLUWALIA A (2017). The anti-inflammatory actions of inorganic nitrate stabilise the atherosclerotic plaque. National Academy of Sciences Proceedings of the National Academy of Sciences of USA 2016
Afzal TA, Luong LA, Chen D, Zhang C, Yang F, Chen Q, An W, Wilkes E, Yashiro K, Cutillas PR, Zhang L and Xiao Q (2016). NCK Associated Protein 1 Modulated by miRNA-214 Determines Vascular Smooth Muscle Cell Migration, Proliferation, and Neointima Hyperplasia. Wiley Journal of the American Heart Association vol. 5, (12) e004629-e004629. Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield MJ (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. Wolters Kluwer Journal of Hypertension vol. 34, (&NA;) Yang W, Ng FL, Chan K, Pu X, Poston RN, Ren M, An W, Zhang R, Wu J, Yan S, Situ H, He X, Chen Y, Tan X, Xiao Q, Tucker AT, Caulfield MJ and Ye S (2016). Coronary-Heart-Disease-Associated Genetic Variant at the COL4A1/COL4A2 Locus Affects COL4A1/COL4A2 Expression, Vascular Cell Survival, Atherosclerotic Plaque Stability and Risk of Myocardial Infarction., Editors: Humphries SE. Public Library of Science PLoS Genetics vol. 12, (7) e1006127-e1006127. Yang F, Chen Q, Wen G, Zhang C, Luong LA, Zhu J, Zhang L and Xiao Q (2016). Functional role of miRNA-34A in smooth muscle cell functions and neointima formation. Elsevier Atherosclerosis vol. 244, e3-e4. 2015
Chen Q, Yang F, Guo M, Wen G, Zhang C, Luong LA, Zhu J, Xiao Q and Zhang L (2015). miRNA-34a reduces neointima formation through inhibiting smooth muscle cell proliferation and migration. Elsevier Journal of Molecular and Cellular Cardiology vol. 89, (Pt A) 75-86. Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M (2015). Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II. Wolters Kluwer Hypertension vol. 66, (suppl_1) Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y and Xu Q (2015). XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling. Wolters Kluwer Arteriosclerosis Thrombosis and Vascular Biology vol. 35, (10) 2134-2144. Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J, Ye S, Xu Q, Wang W and Xiao Q (2015). Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells. Cell Death and Differentiation vol. 22, (7) 1170-1180. Wen G, Zhang C, Chen Q, Luong LA, Mustafa A, Ye S and Xiao Q (2015). A Novel Role of Matrix Metalloproteinase-8 in Macrophage Differentiation and Polarization*. Elsevier Journal of Biological Chemistry vol. 290, (31) 19158-19172. Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong LA, Zhu J, Shu Y, Zhang L and Xiao Q (2015). MicroRNA-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells by Targeting Methyl CpG-Binding Protein 2. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY vol. 35, (4) 918-929. Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. JOURNAL OF HUMAN HYPERTENSION vol. 29, (10) 624-624. 2014
Wen G, Chen Q, Luong LA, Mustafa A, Shu Y and Xiao Q (2014). Matrix metalloproteinase-8 (MMP8) modulates M2 macrophage polarization and molecular mechanisms involved. Elsevier Atherosclerosis vol. 237, (2) Zhao H, Wen G, Huang Y, Yu X, Chen Q, Afzal TA, Luong LA, Zhu J, Shu Y, Zhang L and Xiao Q (2014). MicroRNA-22 regulates smooth muscle cell differentiation from stem cells by targeting methyl CpG binding protein 2. Elsevier Atherosclerosis vol. 237, (2) Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q and Ye S (2014). Matrix metalloproteinase-8 promotes vascular smooth muscle cell proliferation and neointima formation. Arterioscler Thromb Vasc Biol vol. 34, (1) 90-98. 2013
Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z, Yin X, Mayr M, Cockerill G, Li JY-S, Chien S, Hu Y and Xu Q (2013). Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2. J Biol Chem vol. 288, (44) 31853-31866. Luo Z, Wen G, Wang G, Pu X, Ye S, Xu Q, Wang W and Xiao Q (2013). MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1. Stem Cells vol. 31, (9) 1749-1762. Zhao H, Huang Y, Yu X, Wen G, Wang W, Ye S and Xiao Q (2013). Abstract 004: Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2. Wolters Kluwer Circulation Research vol. 113, (suppl_1) Chen Q, Jin M, Yang F, Zhu J, Xiao Q and Zhang L (2013). Matrix metalloproteinases: Inflammatory regulators of cell behaviors in vascular formation and remodeling. Mediators of Inflammation vol. 2013, Fang C, Wen G, Zhang L, Lin L, Moore A, Wu S, Ye S and Xiao Q (2013). An important role of matrix metalloproteinase-8 in angiogenesis in vitro and in vivo. Cardiovasc Res vol. 99, (1) 146-155. Huang Y, Lin L, Yu X, Wen G, Pu X, Zhao H, Fang C, Zhu J, Ye S, Zhang L and Xiao Q (2013). Functional involvements of heterogeneous nuclear ribonucleoprotein A1 in smooth muscle differentiation from stem cells in vitro and in vivo. Stem Cells vol. 31, (5) 906-917. Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Yi-Shuan Li J, Chien S, Hu Y and Xu Q (2013). Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis. Circulation vol. 127, (16) 1712-1722. Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. Am J Hum Genet vol. 92, (3) 366-374. Pu X, Xiao Q, Kiechl S, Chan K, Ng FL, Gor S, Poston RN, Fang C, Patel A, Senver EC, Shaw-Hawkins S, Willeit J, Liu C, Zhu J, Tucker AT, Xu Q, Caulfield MJ and Ye S (2013). ADAMTS7 cleavage and vascular smooth muscle cell migration is affected by a coronary-artery-disease-associated variant. American Journal of Human Genetics vol. 92, (3) 366-374. Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q and Zeng L (2013). XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation. Journal of Biological Chemistry vol. 288, (2) 859-872. Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Yin X, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S (2013). Functional role of matrix metalloproteinase-8 in stem/progenitor cell migration and their recruitment into atherosclerotic lesions. Circ Res vol. 112, (1) 35-47. Zheng X, Wu Y, Zhu L, Chen Q, Zhou Y, Yan H, Chen T, Xiao Q, Zhu J and Zhang L (2013). Angiotensin II promotes differentiation of mouse embryonic stem cells to smooth muscle cells through PI3-kinase signaling pathway and NF-κB. Differentiation vol. 85, (1-2) 41-54. Zhou Y, Yan H, Guo M, Zhu J, Xiao Q and Zhang L (2013). Reactive Oxygen Species in Vascular Formation and Development. OXIDATIVE MEDICINE AND CELLULAR LONGEVITY vol. 2013, Chen Q, Jin M, Zhu J, Xiao Q and Zhang L (2013). Functions of Heterogeneous Nuclear Ribonucleoproteins in Stem Cell Potency and Differentiation. BIOMED RESEARCH INTERNATIONAL vol. 2013, 2012
Ali ZA, Rinze R, Antoniades C, Douglas G, Hu Y, Xiao Q, Greaves D, Alp N, Xu Q and Channon K (2012). Abstract 18700: Accelerated Endothelial Regeneration and Survival Attenuate Vein Graft Atherosclerosis via Terahydrobiopterin-Dependent eNOS Coupling. Wolters Kluwer Circulation vol. 126, (suppl_21) Motterle A, Pu X, Wood H, Xiao Q, Gor S, Ng FL, Chan K, Cross F, Shohreh B, Poston RN, Tucker AT, Caulfield MJ and Ye S (2012). Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells. Hum Mol Genet vol. 21, (18) 4021-4029. Tsai TN, Kirton JP, Campagnolo P, Zhang L, Xiao Q, Zhang Z, Wang W, Hu Y and Xu Q (2012). Contribution of stem cells to neointimal formation of decellularized vessel grafts in a novel mouse model. American Journal of Pathology vol. 181, (1) 362-373. Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y, Ye S and Xu Q (2012). Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells. Arterioscler Thromb Vasc Biol vol. 32, (3) 730-744. Xiao Q, Pepe AE, Wang G, Luo Z, Zhang L, Zeng L, Zhang Z, Hu Y, Ye S and Xu Q (2012). Nrf3-Pla2g7 interaction plays an essential role in smooth muscle differentiation from stem cells. Arteriosclerosis, Thrombosis, and Vascular Biology vol. 32, (3) 730-744. Motterle A, Xiao Q, Kiechl S, Pender SLF, Morris GE, Willeit J, Caulfield MJ and Ye S (2012). Influence of matrix metalloproteinase-12 on fibrinogen level. Atherosclerosis vol. 220, (2) 351-354. Wang G, Xiao Q, Luo Z, Ye S and Xu Q (2012). Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis. J Biol Chem vol. 287, (4) 2896-2906. Wang G, Xiao Q, Luo Z, Ye S and Xu Q (2012). Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis. J Biol Chem. vol. 287, (4) 2896-2906. Liang Q-L, Liang X-P, Wang Y-M, Xie Y-Y, Zhang R-L, Chen X, Gao R, Cheng Y-J, Wu J, Xu Q-B, Xiao Q-Z, Li X, Lv S-F, Fan X-M, Zhang H-Y, Zhang Q-L and Luo G-A (2012). Effective components screening and anti-myocardial infarction mechanism study of the Chinese medicine NSLF6 based on system to system mode. JOURNAL OF TRANSLATIONAL MEDICINE vol. 10, Knoflach M, Kiechl S, Mantovani A, Cuccovillo I, Bottazzi B, Xu Q, Xiao Q, Gasperi A, Mayr A, Kehrer M, Willeit J and Wick G (2012). Pentraxin-3 as a Marker of Advanced Atherosclerosis Results from the Bruneck, ARMY and ARFY Studies. PLOS ONE vol. 7, (2) Huang Y, Lin L, Yu X, Pu X, Zhu J, Zhang L, Ye S and Xiao Q (2012). Functional Involvements of Heterogeneous Nuclear Ribonucleoprotein A1 in Smooth Muscle Differentiation from Stem Cells in vitro and in vivo. CIRCULATION vol. 126, (21) Zhang L, Zheng X, Wu Y, Chen Q, Zhu J and Xiao Q (2012). Microrna-34a Regulates Smooth Muscle Cell Differentiation from Stem Cells by 'Targeting Sirtnin 1. CIRCULATION vol. 126, (21) Luo Z, Wen G, Wang G, Pu X, Wang W, Ye S, Xu Q and Xiao Q (2012). Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi. CIRCULATION vol. 126, (21) Xiao Q, Zhang F, Grassia G, Hu Y, Zhang Z, Xing Q, Yin X, Maddaluno M, Drung B, Schmidt B, Maffia P, Ialenti A, Mayr M, Xu Q and Ye S (2012). Matrix Metalloproteinase-8 Promotes Vascular Smooth Muscle Cell Proliferation and Neointima Formation. CIRCULATION vol. 126, (21) Xiao Q, Zhang F, Lin L, Fang C, Wen G, Tsai T-N, Pu X, Sims D, Zhang Z, Thomaszewski B, Schmidt B, Mayr M, Suzuki K, Xu Q and Ye S (2012). A Functional Role of Matrix Metalloproteinase-8 in Stem/progenitor Cell Migration and Their Recruitment Into Atherosclerotic Lesions. CIRCULATION vol. 126, (21) 2011
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A Novel role for CD34+ Cell-derived Fibroblasts in Abdominal Aortic AneurysmQingzhong Xiao and Qingbo Xu
£346,749 BHF British Heart Foundation (01-11-2023 - 25-02-2027)
Endothelial Repair by CD34+ Stem/Progenitor Cells in AtherosclerosisQingzhong Xiao and Qingbo Xu
£304,530 BHF British Heart Foundation (19-07-2021 - 18-07-2025)
Functional roles of hnRNPA1 in vascular smooth muscle cell phenotype modulation and neointima hyperplasisQingzhong Xiao
£244,031 BHF British Heart Foundation (01-08-2017 - 31-07-2018)