Prof Rob Krams

Rob Krams

Professor of Molecular Bioengineering

School of Engineering and Materials Science
Queen Mary University of London

Research

Cardiovascular Models

Interests

Interested in evaluating miRNA as a new treatment for atherosclerosis. We predict (bioinformatics) and test (high throughput) new miRNA in animal models of atherosclerosis

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Editorial: Computational modelling of cardiovascular hemodynamics and machine learning
Bourantas C, Torii R, Karabasov S and Krams R
Frontiers in Cardiovascular Medicine, Frontiers vol. 11 
22-02-2024
Assessment of the nano-mechanical properties of healthy and atherosclerotic coronary arteries by atomic force microscopy
Savvopoulos F, Keeling MC, Carassiti D, Fogell NA, Patel MB, Naser J, Gavara N, de Silva R and Krams R
Journal of The Royal Society Interface, The Royal Society vol. 21 (211) 
01-02-2024

2023

TCT-613 Comparison of Histology-Trained Deep Learning Approach With Human Expert Analysts for Automated Plaque Component Classification in Hybrid Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves-Kotzev N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia HM, Raber L, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C
Journal of The American College of Cardiology, Elsevier vol. 82 (17), b246-b247.  
01-10-2023
A physics-based machine learning technique rapidly reconstructs the wall-shear stress and pressure fields in coronary arteries
Morgan B, Murali AR, Preston G, Sima YA, Chamorro LM, Bourantas C, Torii R, Mathur A, Baumbach A, Jacob M, Karabasov S and Krams R
Frontiers in Cardiovascular Medicine, Frontiers Media 
29-09-2023
Considering the Influence of Coronary Motion on Artery-Specific Biomechanics Using Fluid–Structure Interaction Simulation
Fogell NAT, Patel M, Yang P, Ruis RM, Garcia DB, Naser J, Savvopoulos F, Davies Taylor C, Post AL, Pedrigi RM, de Silva R and Krams R
Annals of Biomedical Engineering, Springer vol. 51 (9), 1950-1964.  
12-07-2023
Editorial: Computational modeling for assessing coronary artery pathophysiology
Çap M, Torii R, Onuma Y, Krams R, Bennett MR, Stone PH, Serruys PW and Bourantas CV
Frontiers in Cardiovascular Medicine, Frontiers Media vol. 10 
17-01-2023

2022

JAG1-NOTCH4 mechanosensing drives atherosclerosis
Souilhol C, Ayllon BT, Li X, Diagbouga MR, Zhou Z, Canham L, Roddie H, Pirri D, Chambers EV, Dunning MJ, Ariaans M, Li J, Fang Y, Jørgensen HF, Simons M, Krams R, Waltenberger J, Fragiadaki M, Ridger V, De Val S, Francis SE, Chico TJA, Serbanovic-Canic J and Evans PC
Science Advances, American Association For The Advancement of Science vol. 8 (35) 
02-09-2022
TCT-254 Histology-Trained Deep Learning Methodology for Automated Coronary Plaque Component Classification in Combined Intravascular Ultrasound-Optical Coherence Tomography Images
Bajaj R, Huang X, Alves N, Weyers J, Levine M, Garg M, Maung S, Bransby K, Torii R, Krams R, Garcia-Garcia H, Mathur A, Baumbach A, Zhang Q, Courtney B and Bourantas C
Journal of The American College of Cardiology, Elsevier vol. 80 (12) 
01-09-2022

2021

Mechanosensitive pathways are regulated by mechanosensitive miRNA clusters in endothelial cells
Herault S, Naser J, Carassiti D, Chooi KY, Nikolopoulou R, Font ML, Patel M, Pedrigi R and Krams R
Biophysical Reviews, Springer (Part of Springer Nature) vol. 13 (5), 787-796.  
23-10-2021
Moving shear stress towards the clinic: preclinical comparison of optical coherence tomography-based versus angiography-based time-averaged wall shear stress estimations
Naser J, Fogell N, Patel M, Yang P, Krams R, Wentzel JJ, Aben JP and De Silva R
European Heart Journal vol. 42 (Supplement_1) 
12-10-2021
Correction: BS18 Profiling endothelial gene expression in coronary atherosclerotic plaques in a human-like D374Y-PCSK9 hyperlipidaemic porcine model

Heart, Bmj vol. 107 (19), e10-e10.  
14-09-2021
Considerations for analysis of endothelial shear stress and strain in FSI models of atherosclerosis
Patel M, Savvopoulos F, Berggren CC, Aslanidou L, Timmins LH, de Silva R, Pedrigi RM and Krams R
Journal of Biomechanics, Elsevier vol. 128 
28-08-2021

2020

3D co-registration algorithm for catheter-based optical coherence tomography
Post AL, Cernohorsky P, Pedrigi RM, Streekstra GJ, d’Hooghe JNS, Annema JT, Strackee SD, Krams R, van Leeuwen TG, de Bruin DM and Faber DJ
Optics Continuum, Optica Publishing Group vol. 3 (10) 
17-09-2020
Shear Stress Estimated by Quantitative Coronary Angiography Predicts Plaques Prone to Progress and Cause Events
Bourantas CV, Zanchin T, Torii R, Serruys PW, Karagiannis A, Ramasamy A, Safi H, Coskun AU, Koning G, Onuma Y, Zanchin C, Krams R, Mathur A, Baumbach A, Mintz G, Windecker S, Lansky A, Maehara A, Stone PH, Raber L and Stone GW
Jacc Cardiovascular Imaging, Elsevier vol. 13 (10), 2206-2219.  
13-05-2020
Targeted Molecular Iron Oxide Contrast Agents for Imaging Atherosclerotic Plaque
Evans RJ, Lavin B, Phinikaridou A, Chooi KY, Mohri Z, Wong E, Boyle JJ, Krams R, Botnar R and Long NJ
Nanotheranostics, Ivyspring International Publisher vol. 4 (4), 184-194.  
01-01-2020

2019

Expert recommendations on the assessment of wall shear stress in human coronary arteries: existing methodologies, technical considerations, and clinical applications.
Gijsen F, Katagiri Y, Barlis P, Bourantas C, Collet C, Coskun U, Daemen J, Dijkstra J, Edelman E, Evans P, van der Heiden K, Hose R, Koo B-K, Krams R, Marsden A, Migliavacca F, Onuma Y, Ooi A, Poon E, Samady H, Stone P, Takahashi K, Tang D, Thondapu V, Tenekecioglu E, Timmins L, Torii R, Wentzel J and Serruys P
European Heart Journal, Oxford University Press (Oup) 
30-09-2019
Reliable in Vivo Intravascular Imaging Plaque Characterisation: A Challenge Unmet
Baumbach A
American Heart Journal, Elsevier 
23-07-2019
The emerging role of YAP/TAZ in mechanotransduction.
Mohri Z, Del Rio Hernandez A and Krams R
J Thorac Dis vol. 9 (5), E507-E509.  
01-05-2019
Disturbed flow induces a sustained, stochastic NF-κB activation which may support intracranial aneurysm growth in vivo.
Baeriswyl DC, Prionisti I, Peach T, Tsolkas G, Chooi KY, Vardakis J, Morel S, Diagbouga MR, Bijlenga P, Cuhlmann S, Evans P, Kwak BR, Ventikos Y and Krams R
Sci Rep vol. 9 (1), 4738-4738.  
18-03-2019
Plaque burden influences accurate classification of fibrous cap atheroma by in vivo optical coherence tomography in a porcine model of advanced coronary atherosclerosis.
Poulsen CB, Pedrigi RM, Pareek N, Kilic ID, Holm NR, Bentzon JF, Bøtker HE, Falk E, Krams R and de Silva R
Eurointervention vol. 14 (10), 1129-1135.  
20-02-2019

2018

New developments in mechanotransduction: Cross talk of the Wnt, TGF-β and Notch signalling pathways in reaction to shear stress
Abuammah A, Maimari N, Towhidi L, Frueh J, Chooi KY, Warboys C and Krams R
Current Opinion in Biomedical Engineering vol. 5, 96-104.  
01-03-2018

2017

Interferon Regulatory Factor 5 Controls Necrotic Core Formation in Atherosclerotic Lesions by Impairing Efferocytosis.
Seneviratne AN, Edsfeldt A, Cole JE, Kassiteridi C, Swart M, Park I, Green P, Khoyratty T, Saliba D, Goddard ME, Sansom SN, Goncalves I, Krams R, Udalova IA and Monaco C
Circulation, American Heart Association, Inc vol. 136 (12), 1140-1154.  
11-07-2017
Connexin40 controls endothelial activation by dampening NFκB activation.
Denis J-F, Scheckenbach KEL, Pfenniger A, Meens MJ, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak BR
Oncotarget, Impact Journals vol. 8 (31), 50972-50986.  
22-03-2017

2016

Zebrafish Model for Functional Screening of Flow-Responsive Genes.
Serbanovic-Canic J, de Luca A, Warboys C, Ferreira PF, Luong LA, Hsiao S, Gauci I, Mahmoud M, Feng S, Souilhol C, Bowden N, Ashton J-P, Walczak H, Firmin D, Krams R, Mason JC, Haskard DO, Sherwin S, Ridger V, Chico TJA and Evans PC
Arterioscler Thromb Vasc Biol, Wolters Kluwer Health, Inc vol. 37 (1), 130-143.  
10-11-2016
Disturbed Cyclical Stretch of Endothelial Cells Promotes Nuclear Expression of the Pro-Atherogenic Transcription Factor NF-κB.
Pedrigi RM, Papadimitriou KI, Kondiboyina A, Sidhu S, Chau J, Patel MB, Baeriswyl DC, Drakakis EM and Krams R
Ann Biomed Eng, Springer Nature vol. 45 (4), 898-909.  
27-10-2016
Influence of shear stress magnitude and direction on atherosclerotic plaque composition
Pedrigi RM, Mehta VV, Bovens SM, Mohri Z, Poulsen CB, Gsell W, Tremoleda JL, Towhidi L, de Silva R, Petretto E and Krams R
Royal Society Open Science, The Royal Society vol. 3 (10) 
01-10-2016
Development of a synthetic gene network to modulate gene expression by mechanical forces.
Kis Z, Rodin T, Zafar A, Lai Z, Freke G, Fleck O, Del Rio Hernandez A, Towhidi L, Pedrigi RM, Homma T and Krams R
Sci Rep, Springer Nature vol. 6, 29643-29643.  
12-07-2016
0109 : Connexin40 controls endothelial activation by dampening NF B activation
Denis J-F, Scheckenbach L, Pfenniger A, Meens M, Krams R, Miquerol L, Taffet S, Chanson M, Delmar M and Kwak B
Archives of Cardiovascular Diseases Supplements vol. 8 (3), 203-203.  
01-04-2016
Comparison between direct and reverse electroporation of cells in situ: a simulation study
Towhidi L, Khodadadi D, Maimari N, Pedrigi RM, Ip H, Kis Z, Kwak BR, Petrova TW, Delorenzi M and Krams R
Physiological Reports, Wiley vol. 4 (6) 
01-03-2016
Corrigendum to “Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques” [J Mol Cell Cardiol] 89B (2015) 168–172
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C
Journal of Molecular and Cellular Cardiology, Elsevier vol. 91 
01-02-2016
Integration of flow studies for robust selection of mechanoresponsive genes
Maimari N, Pedrigi RM, Russo A, Broda K and Krams R
Thrombosis and Haemostasis, Thieme vol. 115 (03), 474-483.  
01-01-2016

2015

Quantification of plaque stiffness by Brillouin microscopy in experimental thin cap fibroatheroma
Antonacci G, Pedrigi RM, Kondiboyina A, Mehta VV, de Silva R, Paterson C, Krams R and Török P
Journal of The Royal Society Interface, The Royal Society vol. 12 (112) 
01-11-2015
Low shear stress induces M1 macrophage polarization in murine thin-cap atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Park I, Mohri Z, Sansom S, Udalova I, Krams R and Monaco C
Journal of Molecular and Cellular Cardiology, Elsevier vol. 89 (Pt B), 168-172.  
30-10-2015
Shear stress-induced atherosclerotic plaque composition in ApoE−/− mice is modulated by connexin37
Pfenniger A, Meens MJ, Pedrigi RM, Foglia B, Sutter E, Pelli G, Rochemont V, Petrova TV, Krams R and Kwak BR
Atherosclerosis, Elsevier vol. 243 (1), 1-10.  
25-08-2015
Inducing Persistent Flow Disturbances Accelerates Atherogenesis and Promotes Thin Cap Fibroatheroma Development in D374Y-PCSK9 Hypercholesterolemic Minipigs
Pedrigi RM, Poulsen CB, Mehta VV, Ramsing Holm N, Pareek N, Post AL, Kilic ID, Banya WAS, Dall'Ara G, Mattesini A, Bjørklund MM, Andersen NP, Grøndal AK, Petretto E, Foin N, Davies JE, Di Mario C, Fog Bentzon J, Erik Bøtker H, Falk E, Krams R and de Silva R
Circulation, Wolters Kluwer vol. 132 (11), 1003-1012.  
15-07-2015
Enhancement of Non-Invasive Trans-Membrane Drug Delivery Using Ultrasound and Microbubbles During Physiologically Relevant Flow
Shamout FE, Pouliopoulos AN, Lee P, Bonaccorsi S, Towhidi L, Krams R and Choi JJ
Ultrasound in Medicine & Biology, Elsevier vol. 41 (9), 2435-2448.  
09-06-2015
Mammalian synthetic biology: emerging medical applications
Kis Z, Pereira HS, Homma T, Pedrigi RM and Krams R
Journal of The Royal Society Interface, The Royal Society vol. 12 (106) 
01-05-2015
Imaging phase separation in model lipid membranes through the use of BODIPY based molecular rotors
Dent MR, López-Duarte I, Dickson CJ, Geoghegan ND, Cooper JM, Gould IR, Krams R, Bull JA, Brooks NJ and Kuimova MK
Physical Chemistry Chemical Physics, Royal Society of Chemistry (Rsc) vol. 17 (28), 18393-18402.  
01-01-2015

2014

Elevated Uptake of Plasma Macromolecules by Regions of Arterial Wall Predisposed to Plaque Instability in a Mouse Model
Mohri Z, Rowland EM, Clarke LA, De Luca A, Peiffer V, Krams R, Sherwin SJ and Weinberg PD
Plos One, Public Library of Science (Plos) vol. 9 (12) 
22-12-2014
A novel high-throughput platform for siRNA transfection of primary mammalian cells
Towhidi L, Maimari N, Kis Z, Khodadadi D and Krams R
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
Forecasting vulnerable plaque response to aemorheological flow
Pereira G and Krams R
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
Longitudinal predictive analysis of vulnerable plaques in a mouse model of atherosclerosis
Mehta VV, Pedrigi RM, Bovens SM, Tremoleda JL, Gsell W and Krams R
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
A novel integrated platform for gene network inference and validation: beyond the dream consortium
Maimari N, Towhidi L, Oh D, Broda K, Russo A and Krams R
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
Symbolic representation and inference of regulatory networks: uncovering mechanosensitive gene networks
Maimari N, Broda K, Kakas A, Russo A and Krams R
Atherosclerosis, Elsevier vol. 237 (2) 
01-12-2014
Biomechanical factors in atherosclerosis: mechanisms and clinical implications†
Kwak BR, Bäck M, Bochaton-Piallat M-L, Caligiuri G, Daemen MJAP, Davies PF, Hoefer IE, Holvoet P, Jo H, Krams R, Lehoux S, Monaco C, Steffens S, Virmani R, Weber C, Wentzel JJ and Evans PC
European Heart Journal, Oxford University Press (Oup) vol. 35 (43), 3013-3020.  
17-09-2014
In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC
Molecular Imaging, Sage Publications vol. 13 (6) 
01-08-2014
In Vivo Mapping of Vascular Inflammation Using the Translocator Protein Tracer 18F-FEDAA1106.
Cuhlmann S, Gsell W, Van der Heiden K, Habib J, Tremoleda JL, Khalil M, Turkheimer F, Meens MJ, Kwak BR, Bird J, Davenport AP, Clark J, Haskard D, Krams R, Jones H and Evans PC
Mol Imaging vol. 13 (6) 
01-08-2014
Thin-Cap Fibroatheroma Rupture Is Associated With a Fine Interplay of Shear and Wall Stress
Pedrigi RM, de Silva R, Bovens SM, Mehta VV, Petretto E and Krams R
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (10), 2224-2231.  
24-07-2014
Symbolic Representation and Inference of Regulatory Network Structures
Maimari N, Broda K, Kakas A, Krams R and Russo A
In Logical Modeling of Biological Systems, Wiley 1-48.  
10-07-2014
Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow
Gerald C, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Gilson P and Coppola G
Journal of The Royal Society Interface, The Royal Society vol. 11 (92) 
06-03-2014
An In situ electroporation and flow device for mechanotransduction studies
Kis Z, Towhidi L, Ip H, Drakakis E, Bharath A and Krams R
In Microarrays: Principles, Applications and Technologies 49-67.  
01-01-2014

2013

Intimal hyperplasia following implantation of helical-centreline and straight-centreline stents in common carotid arteries in healthy pigs: influence of intraluminal flow†
Gerald C, Seneviratne A, Heraty KB, Monaco C, Burke MG, Krams R, Chang CC, Coppola G and Gilson P
Journal of The Royal Society Interface, The Royal Society vol. 10 (89) 
06-12-2013
Stabilization of atherosclerotic plaques: an update
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jauhiainen S, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C, Tokgözoglu L and Biology EWGOAAV
European Heart Journal, Oxford University Press (Oup) vol. 34 (42), 3251-3258.  
21-08-2013
M1 macrophages are an early feature of shear stress modulated vulnerable atherosclerotic plaques
Seneviratne AN, Cole JE, Goddard ME, Udalova I, Krams R and Monaco C
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl_1) 
02-08-2013
Shear stress and nitric oxide transport affect NFkB dynamics in endothelial cells
Bovens SM, Foin N, O'Clery N, Van Der Heiden K, Cuhlmann S, Carlsen H, Barahona M, Evans PC and Krams R
European Heart Journal, Oxford University Press (Oup) vol. 34 (suppl_1) 
02-08-2013
Method for Percutaneously Introducing, and Removing, Anatomical Stenosis of Predetermined Severity In Vivo: The “Stenotic Stent”
Foin N, Sen S, Petraco R, Nijjer S, Torii R, Kousera C, Broyd C, Mehta V, Xu Y, Mayet J, Hughes A, Di Mario C, Krams R, Francis D and Davies J
Journal of Cardiovascular Translational Research, Springer Nature vol. 6 (4), 640-648.  
04-06-2013
Systems biology of the functional and dysfunctional endothelium
Frueh J, Maimari N, Homma T, Bovens SM, Pedrigi RM, Towhidi L and Krams R
Cardiovascular Research, Oxford University Press (Oup) vol. 99 (2), 334-341.  
06-05-2013
The Role of Platelet-Endothelial Cell Adhesion Molecule-1 in Atheroma Formation Varies Depending on the Site-Specific Hemodynamic Environment
Harrison M, Smith E, Ross E, Krams R, Segers D, Buckley CD, Nash GB and Rainger GE
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 33 (4), 694-701.  
31-01-2013
Arginase inhibition prevents the low shear stress-induced development of vulnerable atherosclerotic plaques in ApoE−/− mice
Olivon VC, Fraga-Silva RA, Segers D, Demougeot C, de Oliveira AM, Savergnini SS, Berthelot A, de Crom R, Krams R, Stergiopulos N and da Silva RF
Atherosclerosis, Elsevier vol. 227 (2), 236-243.  
17-01-2013

2012

Fibromodulin Deficiency Reduces Low-Density Lipoprotein Accumulation in Atherosclerotic Plaques in Apolipoprotein E–Null Mice
Shami A, Gustafsson R, Kalamajski S, Krams R, Segers D, Rauch U, Roos G, Nilsson J, Oldberg Å and Hultgårdh-Nilsson A
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 33 (2), 354-361.  
29-11-2012
Shear stress modulates the expression of the atheroprotective protein Cx37 in endothelial cells
Pfenniger A, Wong C, Sutter E, Cuhlmann S, Dunoyer-Geindre S, Mach F, Horrevoets AJ, Evans PC, Krams R and Kwak BR
Journal of Molecular and Cellular Cardiology, Elsevier vol. 53 (2), 299-309.  
29-05-2012
Systems and synthetic biology of the vessel wall
Frueh J, Maimari N, Lui Y, Kis Z, Mehta V, Pormehr N, Grant C, Chalkias E, Falck-Hansen M, Bovens S, Pedrigi R, Homma T, Coppola G and Krams R
Febs Letters, Wiley vol. 586 (15), 2164-2170.  
03-05-2012
Molecular MR Imaging of Collagen in Mouse Atherosclerosis by Using Paramagnetic CNA35 Micelles
van Bochove GS, Sanders HMHF, de Smet M, Keizer HM, Mulder WJM, Krams R, Strijkers GJ and Nicolay K
European Journal of Inorganic Chemistry, Wiley vol. 2012 (12), 2115-2125.  
28-03-2012
Poster session 1
Schlueter J, Brand T, Henderson DJ, Boczonadi V, Humbert P, Chaudhry B, Sedmera D, Svatunkova J, Kockova R, Sankova B, Lopez Sanchez C, Franco D, Aranega A, Garcia-Martinez V, Demina E, Miroshikova V, Denisenko A, Schwarzman A, Sanchez-Cabo F, Torroja C, Benguria A, Buchan R, Srivastava P, Martinez F, Barton P, Cook S, Dopazo A, Lara-Pezzi E and Rai H
Cardiovascular Research, Oxford University Press (Oup) vol. 93 (suppl_1), s9-s45.  
15-03-2012
Poster session 3
Nanka O, Krejci E, Pesevski Z, Sedmera D, Smart N, Rossdeutsch A, Dube KN, Riegler J, Price AN, Taylor A, Muthurangu V, Turner M, Lythgoe MF, Riley PR, Kryvorot S, Vladimirskaya T, Shved I, Schwarzl M, Seiler S, Huber S, Steendijk P, Maechler H, Truschnig-Wilders M, Pieske B, Post H, Caprio C, Baldini A, Chiavacci E, Dolfi L and Verduci L
Cardiovascular Research, Oxford University Press (Oup) vol. 93 (suppl_1), s92-s127.  
15-03-2012
Implantation of a carotid cuff for triggering shear-stress induced atherosclerosis in mice.
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M
Journal of Visualized Experiments, Myjove (59) 
13-01-2012
Implantation of a Carotid Cuff for Triggering Shear-stress Induced Atherosclerosis in Mice
Kuhlmann MT, Cuhlmann S, Hoppe I, Krams R, Evans PC, Strijkers GJ, Nicolay K, Hermann S and Schäfers M
Journal of Visualized Experiments, Myjove (59) 
13-01-2012
Kissing Balloon or Sequential Dilation of the Side Branch and Main Vessel for Provisional Stenting of Bifurcations Lessons From Micro-Computed Tomography and Computational Simulations
Foin N, Torii R, Mortier P, De Beule M, Viceconte N, Chan PH, Davies JE, Xu XY, Krams R and Di Mario C
Jacc Cardiovascular Interventions, Elsevier vol. 5 (1), 47-56.  
01-01-2012

2011

Final proximal post-dilatation is necessary after kissing balloon in bifurcation stenting.
Foin N, Secco GG, Ghilencea L, Krams R and Di Mario C
Eurointervention, Europa Digital & Publishing vol. 7 (5), 597-604.  
01-09-2011
Jailed side branches
Foin N, Viceconte N, Chan PH, Lindsay AC, Krams R and Di Mario C
Journal of Cardiovascular Medicine, Wolters Kluwer vol. 12 (8), 581-582.  
01-08-2011
Shear stress is a major determinant for getting a heart attack
De Crom R, Leenen P, Nicolay K and Krams R
Hart Bulletin vol. 42 (3), 67-70.  
01-06-2011
Disturbed Blood Flow Induces RelA Expression via c-Jun N-Terminal Kinase 1
Cuhlmann S, Van der Heiden K, Saliba D, Tremoleda JL, Khalil M, Zakkar M, Chaudhury H, Luong LA, Mason JC, Udalova I, Gsell W, Jones H, Haskard DO, Krams R and Evans PC
Circulation Research, Wolters Kluwer vol. 108 (8), 950-959.  
24-02-2011
Dexamethasone Arterializes Venous Endothelial Cells by Inducing Mitogen-Activated Protein Kinase Phosphatase-1
Zakkar M, Luong LA, Chaudhury H, Ruud O, Punjabi PP, Anderson JR, Mullholand JW, Clements AT, Krams R, Foin N, Athanasiou T, Leen ELS, Mason JC, Haskard DO and Evans PC
Circulation, Wolters Kluwer vol. 123 (5), 524-532.  
24-01-2011
18FEDAA is a more specific probe than 18FDG for imaging vascular inflammation
Gsell W, Cuhlmann S, Van der Heiden K, Tremoleda JL, Khalil M, Clark J, Bird J, Jones H, Krams R and Evans PC
European Journal of Nuclear Medicine and Molecular Imaging vol. 38, S210-S210.  
01-01-2011
Stabilisation of atherosclerotic plaques
Ylä-Herttuala S, Bentzon JF, Daemen M, Falk E, Garcia-Garcia HM, Herrmann J, Hoefer I, Jukema JW, Krams R, Kwak BR, Marx N, Naruszewicz M, Newby A, Pasterkamp G, Serruys PWJC, Waltenberger J, Weber C and Tokgözoglu L
Thrombosis and Haemostasis, Thieme vol. 106 (01), 1-19.  
01-01-2011
Atherosclerotic Plaque Stability Is Affected by the Chemokine CXCL10 in Both Mice and Humans
Segers D, Lipton JA, Leenen PJM, Cheng C, Tempel D, Pasterkamp G, Moll FL, de Crom R and Krams R
International Journal of Inflammation, Hindawi vol. 2011 (1) 
01-01-2011

2010

Multi-scale interaction of particulate flow and the artery wall
Halliday I, Atherton M, Care CM, Collins MW, Evans D, Evans PC, Hose DR, Khir AW, König CS, Krams R, Lawford PV, Lishchuk SV, Pontrelli G, Ridger V, Spencer TJ, Ventikos Y, Walker DC and Watton PN
Medical Engineering & Physics, Elsevier vol. 33 (7), 840-848.  
29-10-2010
Contrast enhancement by differently sized paramagnetic MRI contrast agents in mice with two phenotypes of atherosclerotic plaque
van Bochove GS, Paulis LEM, Segers D, Mulder WJM, Krams R, Nicolay K and Strijkers GJ
Contrast Media & Molecular Imaging, Wiley vol. 6 (1), 35-45.  
29-09-2010
Microcalcifications in atherosclerotic lesion of apolipoprotein E‐deficient mouse
Debernardi N, Roijers RB, Krams R, De Crom R, Mutsaers PHA and Van Der Vusse GJ
International Journal of Experimental Pathology, Wiley vol. 91 (6), 485-494.  
27-08-2010
YIA4 C Jun N-terminal kinase promotes endothelial activation at atherosclerosis-susceptible sites by enhancing expression of NF-κB transcription factors
Cuhlmann S, van der Heiden K, Zakkar M, Chaudhury H, Luong LA, Mason J, Haskard DO, Carlsen H, Krams R and Evans PC
Heart, Bmj vol. 96 (17) 
26-08-2010
Endothelial Nitric Oxide Production and Transport in Flow Chambers: The Importance of Convection
Plata AM, Sherwin SJ and Krams R
Annals of Biomedical Engineering, Springer Nature vol. 38 (9), 2805-2816.  
14-04-2010
Predicting Patient-Specific Expansion of Abdominal Aortic Aneurysms
Helderman F, Manoch IJ, Breeuwer M, Kose U, Boersma H, van Sambeek MRHM, Pattynama PMT, Schouten O, Poldermans D, Wisselink W, van der Steen AFW and Krams R
European Journal of Vascular and Endovascular Surgery, Elsevier vol. 40 (1), 47-53.  
25-03-2010
MRI-determined carotid artery flow velocities and wall shear stress in a mouse model of vulnerable and stable atherosclerotic plaque
van Bochove GS, Straathof R, Krams R, Nicolay K and Strijkers GJ
Magnetic Resonance Materials in Physics, Biology and Medicine, Springer Nature vol. 23 (2), 77-84.  
13-03-2010
Flow Interactions with Cells and Tissues: Cardiovascular Flows and Fluid–Structure Interactions
Friedman MH, Krams R and Chandran KB
Annals of Biomedical Engineering, Springer Nature vol. 38 (3), 1178-1187.  
14-01-2010
c-Jun N-Terminal Kinase Primes Endothelial Cells at Atheroprone Sites for Apoptosis
Chaudhury H, Zakkar M, Boyle J, Cuhlmann S, van der Heiden K, Luong LA, Davis J, Platt A, Mason JC, Krams R, Haskard DO, Clark AR and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 30 (3), 546-553.  
07-01-2010
Shear stress, inflammation and Atherosclerosis
Krams R, Cuhlmann S, Foin N and Evans P
Artery Research, Springer Nature vol. 4 (2), 41-46.  
01-01-2010

2009

Activation of Nrf2 in Endothelial Cells Protects Arteries From Exhibiting a Proinflammatory State
Zakkar M, Van der Heiden K, Luong LA, Chaudhury H, Cuhlmann S, Hamdulay SS, Krams R, Edirisinghe I, Rahman I, Carlsen H, Haskard DO, Mason JC and Evans PC
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 29 (11), 1851-1857.  
03-09-2009
Activation of MMP8 and MMP13 by angiotensin II correlates to severe intra-plaque hemorrhages and collagen breakdown in atherosclerotic lesions with a vulnerable phenotype
Cheng C, Tempel D, van Haperen R, van Damme L, Algür M, Krams R and de Crom R
Atherosclerosis, Elsevier vol. 204 (1), 26-33.  
24-01-2009
SHEAR STRESS AND MASS TRANSPORT AFFECTS NFκB DYNAMICS IN ENDOTHELIAL CELLS
Foin N, Plata-Garcia A, Cuhlmann S, Evans P, Caro C and Krams R
Journal of Physiological Sciences vol. 59, 324-324.  
01-01-2009

2008

Donor pre-treatment with tacrolimus reduces transplant vasculopathy
Susa D, van de Engel S, van Damme LCA, Roest HP, Krams R, IJzermans JNM and de Bruin RWF
Pharmacological Research, Elsevier vol. 59 (4), 273-278.  
30-12-2008
Atherosclerosis: cell biology and lipoproteins - shear stress and inflammation in plaque formation: new evidence
Segers D, Weinberg P and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 19 (6), 627-628.  
01-12-2008
Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach
Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ, Serruys PW, Steen AFWVD and Krams R
Vascular Disease Prevention, Bentham Science Publishers vol. 2 (1), 227-235.  
01-12-2008
Personalised imaging and biomechanical modelling of large vessels
Krams R, Breeuwer M and van de Vosse F
Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11), 1057-1058.  
01-11-2008
A primer on the immune system in the pathogenesis and treatment of atherosclerosis.
Segers D, Garcia-Garcia HM, Cheng C, de Crom R, Krams R, Wentzel JJ, van der Steen AFW, Serruys PW, Leenen PJM and Laman JD
Eurointervention, Europa Digital & Publishing vol. 4 (3), 378-390.  
01-11-2008
Pulmonary artery size and function after Fontan operation at a young age
Robbers‐Visser D, Helderman F, Strengers JL, van Osch‐Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R and Helbing WA
Journal of Magnetic Resonance Imaging, Wiley vol. 28 (5), 1101-1107.  
28-10-2008
1057 Pulmonary artery size and function after Fontan operation at young age: assessment with phase contrast magnetic resonance imaging
Robbers-Visser D, Helderman F, Strengers JL, van Osch-Gevers L, Kapusta L, Pattynama PM, Bogers AJ, Krams R and Helbing WA
Journal of Cardiovascular Magnetic Resonance, Elsevier vol. 10 
01-10-2008
Towards patient-specific risk assessment of abdominal aortic aneurysm
Breeuwer M, de Putter S, Kose U, Speelman L, Visser K, Gerritsen F, Hoogeveen R, Krams R, van den Bosch H, Buth J, Gunther T, Wolters B, van Dam E and van de Vosse F
Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11), 1085-1095.  
23-09-2008
Large variations in absolute wall shear stress levels within one species and between species
de Crom R, Cheng C, Helderman F and Krams R
Atherosclerosis, Elsevier vol. 204 (1), 16-17.  
22-08-2008
Increased Endothelial Mitogen-Activated Protein Kinase Phosphatase-1 Expression Suppresses Proinflammatory Activation at Sites That Are Resistant to Atherosclerosis
Zakkar M, Chaudhury H, Sandvik G, Enesa K, Luong LA, Cuhlmann S, Mason JC, Krams R, Clark AR, Haskard DO and Evans PC
Circulation Research, Wolters Kluwer vol. 103 (7), 726-732.  
21-08-2008
Hemodynamic parameters regulating vascular inflammation and atherosclerosis: A brief update
Ridger V, Krams R, Carpi A and Evans PC
Biomedicine & Pharmacotherapy, Elsevier vol. 62 (8), 536-540.  
08-08-2008
DONOR PRE-TREATMENT WITH TACROLIMUS EDUCES TRANSPLANT VASCULOPATHY
de Bruin RWF, Susa D, van den Engel S, van Damme LA, Roest HP, Krams R and Jzermans JNMI
Transplantation, Wolters Kluwer vol. 86 (2S) 
27-07-2008
REGULATION OF ARGINASE IN RESPONSE SHEAR STRESS: NEW POTENTIAL THERAPEUTIC TARGET ATHEROSCLEROSIS?
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N
Journal of Biomechanics, Elsevier vol. 41 
01-07-2008
A numerical model to predict abdominal aortic aneurysm expansion based on local wall stress and stiffness
Helderman F, Manoch IJ, Breeuwer M, Kose U, Schouten O, van Sambeek MRM, Poldermans D, Pattynama PTM, Wisselink W, van der Steen AFW and Krams R
Medical & Biological Engineering & Computing, Springer Nature vol. 46 (11) 
03-06-2008
Atherosclerosis: cell biology and lipoproteins – new developments in imaging of inflammation of the vulnerable plaque
Foin N, Evans P and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 19 (1), 98-100.  
01-02-2008
P1.57 Modulation of Arginase in Response to Wall Shear Stress
da Silva RF, Olivon VC, Segers D, de Crom R, Krams R and Stergiopulos N
Artery Research, Springer Nature vol. 2 (3), 105-106.  
01-01-2008

2007

Rapamycin modulates the eNOS vs. shear stress relationship
Cheng C, Tempel D, Oostlander A, Helderman F, Gijsen F, Wentzel J, van Haperen R, Haitsma DB, Serruys PW, van der Steen AFW, de Crom R and Krams R
Cardiovascular Research, Oxford University Press (Oup) vol. 78 (1), 123-129.  
13-12-2007
Abstract 879: The Chemokine CXCL10 Is Involved In The Development Of Atherosclerotic Plaque Vulnerability
Segers D, de Crom R, Leenen P, Pasterkamp G and Krams R
Circulation, Wolters Kluwer vol. 116 (suppl_16) 
16-10-2007
Effect of shear stress on vascular inflammation and plaque development
Helderman F, Segers D, de Crom R, Hierck BP, Poelmann RE, Evans PC and Krams R
Current Opinion in Lipidology, Wolters Kluwer vol. 18 (5), 527-533.  
01-10-2007
Subharmonic Contrast Intravascular Ultrasound for Vasa Vasorum Imaging
Goertz DE, Frijlink ME, Tempel D, Bhagwandas V, Gisolf A, Krams R, de Jong N and van der Steen AFW
Ultrasound in Medicine & Biology, Elsevier vol. 33 (12), 1859-1872.  
02-08-2007
Endothelial primary cilia in areas of disturbed flow are at the base of atherosclerosis
Van der Heiden K, Hierck BP, Krams R, de Crom R, Cheng C, Baiker M, Pourquie MJBM, Alkemade FE, DeRuiter MC, Groot ACG-D and Poelmann RE
Atherosclerosis, Elsevier vol. 196 (2), 542-550.  
13-07-2007
Shear stress and the vulnerable plaque
Wentzel J, Gijsen F, Krams R, de Crom R, Cheng C, Groen H, van der Giessen A and van der Steen A
In The Vulnerable Plaque, Second Edition, Taylor & Francis 233-244.  
13-06-2007
Coronary flow reserve in hypertrophic cardiomyopathy: relation with microvascular dysfunction and pathophysiological characteristics
Kofflard MJ, Michels M, Krams R, Kliffen M, Geleijnse ML, Cate FJT and Serruys PW
Netherlands Heart Journal, Springer Nature vol. 15 (6), 209-215.  
01-06-2007
Assessment of Unstable Atherosclerosis in Mice
Jackson CL, Bennett MR, Biessen EAL, Johnson JL and Krams R
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 27 (4), 714-720.  
01-03-2007
Shear stress–induced changes in atherosclerotic plaque composition are modulated by chemokines
Cheng C, Tempel D, van Haperen R, de Boer HC, Segers D, Huisman M, van Zonneveld AJ, Leenen PJM, van der Steen A, Serruys PW, de Crom R and Krams R
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 117 (3), 616-626.  
15-02-2007
Vasa vasorum and molecular imaging of atherosclerotic plaques using nonlinear contrast intravascular ultrasound
Goertz DE, Frijlink ME, Krams R, de Jong N and van der Steen AFW
Netherlands Heart Journal, Springer Nature vol. 15 (2), 77-80.  
01-02-2007
Gelatinolytic Activity in Atherosclerotic Plaques Is Highly Localized and Is Associated With Both Macrophages and Smooth Muscle Cells In Vivo
Segers D, Helderman F, Cheng C, van Damme LCA, Tempel D, Boersma E, Serruys PW, de Crom R, van der Steen AFW, Holvoet P and Krams R
Circulation, Wolters Kluwer vol. 115 (5), 609-616.  
22-01-2007
Modulation of arginases by different patterns of shear stress: new signaling pathway in atherogenesis?
Da Silva RF, Gambillara V, Krams R and Stergiopulos N
Computer Methods in Biomechanics & Biomedical Engineering, Taylor & Francis vol. 10 (sup1), 77-78.  
01-01-2007
P.096 Role of Arginase Pathway in Response to Shear Stress: New Potential Therapeutic Targets for Atherosclerosis?
da Silva RF, Gambillara V, Cheng C, Segers D, de Crom R, Krams R and Stergiopulos N
Artery Research, Springer Nature vol. 1 (2), 74-75.  
01-01-2007
The Influence of Shear Stress on Restenosis
Thury A, Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ
In Essentials of Restenosis, Springer Nature 59-83.  
01-01-2007

2006

Large variations in absolute wall shear stress levels within one species and between species
Cheng C, Helderman F, Tempel D, Segers D, Hierck B, Poelmann R, van Tol A, Duncker DJ, Robbers-Visser D, Ursem NTC, van Haperen R, Wentzel JJ, Gijsen F, van der Steen AFW, de Crom R and Krams R
Atherosclerosis, Elsevier vol. 195 (2), 225-235.  
12-12-2006
Response to Letter Regarding Article, “Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress”
Cheng C, Tempel D, van der Baan A, Krams R, Daemen MJAP, van Haperen R, Grosveld F and de Crom R
Circulation, Wolters Kluwer vol. 114 (22) 
28-11-2006
Harmonic intravascular ultrasound imaging with a dual-frequency catheter
Frijlink ME, Goertz DE, Vos HJ, Tesselaar E, Blacquière G, Gisolf A, Krams R and van der Steen AFW
Ultrasound in Medicine & Biology, Elsevier vol. 32 (11), 1649-1654.  
01-11-2006
Intravascular ultrasound tissue harmonic imaging in vivo
Frijlink ME, Goertz DE, van Damme LCA, Krams R and van der Steen AFW
Ieee Transactions On Ultrasonics Ferroelectrics and Frequency Control, Institute of Electrical and Electronics Engineers (Ieee) vol. 53 (10), 1844-1852.  
01-10-2006
Angiotensin II induces severe intra-plaque hemorrhages in lesions with a vulnerable plaque phenotype
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R
Vascular Pharmacology, Elsevier vol. 45 (3), e91-e92.  
01-09-2006
Patterns of fluid shear stress determine atherosclerotic lesion size and vulnerability
Cheng C, Tempel D, van Damme L, van Haperen R, Krams R and de Crom R
Vascular Pharmacology, Elsevier vol. 45 (3) 
01-09-2006
Contrast Harmonic Intravascular Ultrasound
Goertz DE, Frijlink ME, Tempel D, van Damme LCA, Krams R, Schaar JA, Cate FJT, Serruys PW, de Jong N and van der Steen AFW
Investigative Radiology, Wolters Kluwer vol. 41 (8), 631-638.  
01-08-2006
Shear stress is associated with markers of plaque vulnerability and MMP-9 activity.
Krams R, Cheng C, Helderman F, Verheye S, van Damme LCA, Mousavi Gourabi B, Tempel D, Segers D, de Feyter P, Pasterkamp G, De Klein D, de Crom R, van der Steen AFW and Serruys PW
Eurointervention vol. 2 (2), 250-256.  
01-08-2006
Atherosclerotic Lesion Size and Vulnerability Are Determined by Patterns of Fluid Shear Stress
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R and de Crom R
Circulation, Wolters Kluwer vol. 113 (23), 2744-2753.  
05-06-2006
Norepinephrine-induced vasoconstriction results in decreased blood volume in dialysis patients
Nette RW, Ie EHY, Vletter WB, Krams R, Weimar W and Zietse R
Nephrology Dialysis Transplantation, Oxford University Press (Oup) vol. 21 (5), 1305-1311.  
31-01-2006
Atherosclerotic lesion size and vulnerability are determined by patterns of fluid shear stress
Cheng C, Tempel D, van Haperen R, van der Baan A, Grosveld F, Daemen MJAP, Krams R and de Crom R
Circulation vol. 113 (23), 2744-2753.  
01-01-2006
Visualization of the Vulnerable Plaque
Krams R, Schaar J, Helderman F, Cheng C, Gourabi BM, van Damme LCA, Segers D, Regar E, Slager CJ, de Feyter PJ, van der Steen AFW and Serruys PW
In Cardiovascular Research, Springer Nature 221-234.  
01-01-2006
Numerical model for predicting dilatation of an Abdominal Aortic Aneurysm (AAA)
Helderman F, Schouten O, Manoch I, Buffart H, van der Steen AFW and Krams R
Journal of Biomechanics, Elsevier vol. 39 
01-01-2006
Shear stress and atherosclerosis
Krams R
Journal of Biomechanics, Elsevier vol. 39 
01-01-2006

2005

Shear Stress Biology of the Endothelium
Davies PF, Spaan JA and Krams R
Annals of Biomedical Engineering, Springer Nature vol. 33 (12), 1714-1718.  
01-12-2005
In vivo temperature heterogeneity is associated with plaque regions of increased MMP-9 activity
Krams R, Verheye S, van Damme LCA, Tempel D, Mousavi Gourabi B, Boersma E, Kockx MM, Knaapen MWM, Strijder C, van Langenhove G, Pasterkamp G, van der Steen AFW and Serruys PW
European Heart Journal, Oxford University Press (Oup) vol. 26 (20), 2200-2205.  
05-09-2005
Myocardial contractility does not determine the haemodynamic response during dialysis
Ie EHY, Krams R, Vletter WB, Nette RW, Weimar W and Zietse R
Nephrology Dialysis Transplantation, Oxford University Press (Oup) vol. 20 (11), 2465-2471.  
23-08-2005
Shear stress affects the intracellular distribution of eNOS: direct demonstration by a novel in vivo technique
Cheng C, van Haperen R, de Waard M, van Damme LCA, Tempel D, Hanemaaijer L, van Cappellen GWA, Bos J, Slager CJ, Duncker DJ, van der Steen AFW, de Crom R and Krams R
Blood, American Society of Hematology vol. 106 (12), 3691-3698.  
16-08-2005
Monocyte Adhesion in Atherosclerosis: A Biomechanical Approach
Segers D, Cheng C, Crom RD, Kirschbaum SWM, Oostlander AE, Helderman F, Wamel AV, Slager CJ, Serruys PW, Steen AFWVD and Krams R
Vascular Disease Prevention, Bentham Science Publishers vol. 2 (3), 227-235.  
01-07-2005
Effect of vessel curvature on Doppler derived velocity profiles and fluid flow
Krams R, Bambi G, Guidi F, Helderman F, van der Steen AFW and Tortoli P
Ultrasound in Medicine & Biology, Elsevier vol. 31 (5), 663-671.  
01-05-2005
Letter Regarding Article by Korshunov and Berk, “Strain-Dependent Vascular Remodeling: The ‘Glagov Phenomenon’ Is Genetically Determined”
Wentzel JJ, Krams R and Slager CJ
Circulation, Wolters Kluwer vol. 111 (9), e119-e119.  
21-02-2005
Three-Dimensional Palpography of Human Coronary Arteries
Schaar* JA, de Korte* CL, Mastik F, van Damme LCA, Krams R, Serruys PW and van der Steen AFW
Herz, Springer Nature vol. 30 (2), 125-133.  
01-02-2005

2004

Geometry guided data averaging enables the interpretation of shear stress related plaque development in human coronary arteries
Wentzel JJ, Gijsen FJH, Schuurbiers JCH, Krams R, Serruys PW, De Feyter PJ and Slager CJ
Journal of Biomechanics, Elsevier vol. 38 (7), 1551-1555.  
23-12-2004
Diastolic coronary vascular reserve: a new index to detect changes in the coronary microcirculation in hypertrophic cardiomyopathy
Krams R, Cate FJT, Carlier SG, van der Steen AFW and Serruys PW
Journal of The American College of Cardiology, Elsevier vol. 43 (4), 670-677.  
01-02-2004
Intravascular thermography: Immediate functional and morphological vascular findings
Verheye S, De Meyer GRY, Krams R, Kockx MM, Van Damme LCA, Mousavi Gourabi B, Knaapen MWM, Van Langenhove G and Serruys PW
European Heart Journal, Oxford University Press (Oup) vol. 25 (2), 158-165.  
01-01-2004
The role of shear stress in atherosclerosis
Cheng C, de Crom R, van Haperen R, Helderman F, Gourabi BM, van Damme LCA, Kirschbaum SW, Slager CJ, van der Steen AFW and Krams R
Cell Biochemistry and Biophysics, Springer Nature vol. 41 (2), 279-294.  
01-01-2004
Multi-Dimensional Computed Coronary Visualization
van Ooijen PMA, Irwan R, Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW and de Feyter PJ
In Coronary Radiology, Springer Nature 227-282.  
01-01-2004

2003

Functional Expression of Endothelial Nitric Oxide Synthase Fused to Green Fluorescent Protein in Transgenic Mice
van Haperen R, Cheng C, Mees BME, van Deel E, de Waard M, van Damme LCA, van Gent T, van Aken T, Krams R, Duncker DJ and de Crom R
American Journal of Pathology, Elsevier vol. 163 (4), 1677-1686.  
01-10-2003
The effect of reduced blood-flow on the coronary wall temperature
Diamantopoulos L, Liu X, De Scheerder I, Krams R, Li S, Van Cleemput J, Desmet W and Serruys PW
European Heart Journal, Oxford University Press (Oup) vol. 24 (19), 1788-1795.  
01-10-2003
Imaging of coronary atherosclerosis and identification of the vulnerable plaque.
de Feyter PJ, Serruys PW, Nieman K, Mollet N, Cademartiri F, van Geuns RJ, Slager C, van der Steen AFW, Krams R, Schaar JA, Wielopolski P, Pattynama PMT, Arampatzis A, van der Lugt A, Regar E, Ligthart J and Smits P
Netherlands Heart Journal vol. 11 (9), 347-358.  
01-09-2003
Extension of Increased Atherosclerotic Wall Thickness Into High Shear Stress Regions Is Associated With Loss of Compensatory Remodeling
Wentzel JJ, Janssen E, Vos J, Schuurbiers JCH, Krams R, Serruys PW, de Feyter PJ and Slager CJ
Circulation, Wolters Kluwer vol. 108 (1), 17-23.  
23-06-2003
Augmentation of Wall Shear Stress Inhibits Neointimal Hyperplasia After Stent Implantation
Carlier SG, van Damme LCA, Blommerde CP, Wentzel JJ, van Langehove G, Verheye S, Kockx MM, Knaapen MWM, Cheng C, Gijsen F, Duncker DJ, Stergiopulos N, Slager CJ, Serruys PW and Krams R
Circulation, Wolters Kluwer vol. 107 (21), 2741-2746.  
12-05-2003
Shear stress, vascular remodeling and neointimal formation
Wentzel JJ, Gijsen FJH, Stergiopulos N, Serruys PW, Slager CJ and Krams R
Journal of Biomechanics, Elsevier vol. 36 (5), 681-688.  
01-05-2003
Inflammation and Atherosclerosis:
KRAMS R, SEGERS D, GOURABI BM, MAAT W, CHENG C, VAN PELT C, VAN DAMME LCA, DE FEYTER P, VAN DER STEEN T, DE KORTE CL and SERRUYS PW
Journal of Interventional Cardiology, Wiley vol. 16 (2), 107-113.  
01-04-2003
Diagnosis of vulnerable plaques in the cardiac catheterization laboratory
Schaar JA, van der Steen AFW, Arampatzis CA, Krams R, Slager CJ, ten Have AG, van de Poll SW, Gijsen FJ, Wentzel JJ, de Feyter PJ and Serruys PW
In Vascular Ultrasound, Springer Nature 220-234.  
01-01-2003
Shear stress and the IVUS derived vessel wall thickness
Wentzel JJ, Cheng C, de Crom R, Stergiopulos N, Serruys PW, Slager CJ and Krams R
In Vascular Ultrasound, Springer Nature 148-164.  
01-01-2003
Coronary 3-D angiography, 3-D ultrasound and their fusion
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Gijsen FJH, Krams R, van der Giessen WJ, Serruys PW and de Feyter PJ
In Vascular Ultrasound, Springer Nature 121-147.  
01-01-2003

2002

High shear stress after successful balloon angioplasty is associated with restenosis and target lesion revascularization
Thury A, van Langenhove G, Carlier SG, Albertal M, Kozuma K, Regar E, Sianos G, Wentzel JJ, Krams R, Slager CJ, Piek JJ, Serruys PW and Investigators D
American Heart Journal, Elsevier vol. 144 (1), 136-143.  
01-07-2002
Focal In-Stent Restenosis Near Step-Up
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ
Circulation, Wolters Kluwer vol. 105 (23), 185e-1187.  
11-06-2002
Calcium Sensitizer EMD 57033, But Not the β 1 -Adrenoreceptor Agonist Dobutamine, Increases Mechanical Efficiency in Stunned Myocardium
Trines SAIP, Smits CAG, van der Moer J, Slager CJ, Verdouw PD and Krams R
Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 39 (1), 61-72.  
01-01-2002
Focal in-stent restenosis near step-up - Roles of low and oscillating shear stress?
Thury A, Wentzel JJ, Vinke RVH, Gijsen FJH, Schuurbiers JCH, Krams R, de Feyter PJ, Serruys PW and Slager CJ
Circulation vol. 105 (23), E185-E187.  
01-01-2002

2001

Prominent Role of Tensile Stress in Propagation of a Dissection After Coronary Stenting
Thury A, Wentzel JJ, Schuurbiers JCH, Ligthart JMR, Krams R, de Feyter PJ, Serruys PW and Slager CJ
Circulation, Wolters Kluwer vol. 104 (11), e53-e54.  
11-09-2001
Decrease in coronary vascular volume in systole augments cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N
Ajp Heart and Circulatory Physiology, American Physiological Society vol. 281 (2), h731-h737.  
01-08-2001
Shear-Stress and Wall-Stress Regulation of Vascular Remodeling After Balloon Angioplasty
Wentzel JJ, Kloet J, Andhyiswara I, Oomen JAF, Schuurbiers JCH, de Smet BJGL, Post MJ, de Kleijn D, Pasterkamp G, Borst C, Slager CJ and Krams R
Circulation, Wolters Kluwer vol. 104 (1), 91-96.  
03-07-2001
Oxygen wastage of stunned myocardium in vivo is due to an increased oxygen cost of contractility and a decreased myofibrillar efficiency
Trines SAIP, Slager CJ, Onderwater TAM, Lamers JMJ, Verdouw PD and Krams R
Cardiovascular Research, Oxford University Press (Oup) vol. 51 (1), 122-130.  
01-07-2001
Relationship Between Neointimal Thickness and Shear Stress After Wallstent Implantation in Human Coronary Arteries
Wentzel JJ, Krams R, Schuurbiers JCH, Oomen JA, Kloet J, van der Giessen WJ, Serruys PW and Slager CJ
Circulation, Wolters Kluwer vol. 103 (13), 1740-1745.  
03-04-2001
Decrease in coronary vascular volume in systole augments cardiac contraction
Willemsen MJJMF, Duncker DJ, Krams R, Dijkman MA, Lamberts RR, Sipkema P and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 281 (2 50-2) 
01-01-2001

2000

Coronary stent implantation changes 3-D vessel geometry and 3-D shear stress distribution
Wentzel JJ, Whelan DM, van der Giessen WJ, van Beusekom HMM, Andhyiswara I, Serruys PW, Slager CJ and Krams R
Journal of Biomechanics, Elsevier vol. 33 (10), 1287-1295.  
01-10-2000
In vivo evidence that EMD 57033 restores myocardial responsiveness to intracoronary Ca2+ in stunned myocardium
de Zeeuw S, Trines SAIP, Krams R, Duncker DJ and Verdouw PD
European Journal of Pharmacology, Elsevier vol. 403 (1-2), 99-109.  
01-09-2000
Efficiency of energy transfer, but not external work, is maximized in stunned myocardium
Trines SAIP, Slager CJ, Van der Moer J, Verdouw PD and Krams R
Ajp Heart and Circulatory Physiology, American Physiological Society vol. 279 (3), h1264-h1273.  
01-09-2000
True 3-Dimensional Reconstruction of Coronary Arteries in Patients by Fusion of Angiography and IVUS (ANGUS) and Its Quantitative Validation
Slager CJ, Wentzel JJ, Schuurbiers JCH, Oomen JAF, Kloet J, Krams R, von Birgelen C, van der Giessen WJ, Serruys PW and de Feyter PJ
Circulation, Wolters Kluwer vol. 102 (5), 511-516.  
01-08-2000
Helical Velocity Patterns in a Human Coronary Artery
Van Langenhove G, Wentzel JJ, Krams R, Slager CJ, Hamburger JN and Serruys PW
Circulation, Wolters Kluwer vol. 102 (3), e22-e24.  
18-07-2000
Cardiovascular profile of the calcium sensitizer EMD 57033 in open‐chest anaesthetized pigs with regionally stunned myocardium
De Zeeuw S, Trines SAIP, Krams R, Verdouw PD and Duncker DJ
British Journal of Pharmacology, Wiley vol. 129 (7), 1413-1422.  
01-04-2000
Quantification of plaque volume, shear stress on the endothelium, and mechanical properties of the arterial wall with intravascular ultrasound imaging
Bom N, de Korte CL, Wentzel JJ, Krams R, Carlier SG, van der Steen AWF, Slager CJ and Roelandt JRTC
Clinical Research in Cardiology, Springer Nature vol. 89 (Suppl 2), s105-s111.  
01-02-2000
Efficiency of energy transfer, but not external work, is maximized in stunned myocardium
Trines SAIP, Slager CJ, Van Der Moer J, Verdouw PD and Krams R
American Journal of Physiology - Heart and Circulatory Physiology vol. 279 (3 48-3) 
01-01-2000

1999

Ca2+ sensitization and diastolic function of normal and stunned porcine myocardium
Soei LK, de Zeeuw S, Krams R, Duncker DJ and Verdouw PD
European Journal of Pharmacology, Elsevier vol. 386 (1), 55-67.  
01-12-1999
Effect of catheter placement on 3-D velocity profiles in curved tubes resembling the human coronary system
Krams R, Wentzel JJ, Cespedes I, Vinke R, Carlier S, van der Steen AFW, Lancee CT and Slager CJ
Ultrasound in Medicine & Biology, Elsevier vol. 25 (5), 803-810.  
01-06-1999

1998

AT1 Receptor A/C1166 Polymorphism Contributes to Cardiac Hypertrophy in Subjects With Hypertrophic Cardiomyopathy
Osterop APRM, Kofflard MJM, Sandkuijl LA, Cate FJT, Krams R, Schalekamp MADH and Danser AHJ
Hypertension, Wolters Kluwer vol. 32 (5), 825-830.  
01-11-1998
Shear stress in atherosclerosis, and vascular remodelling.
Krams R, Wentzel JJ, Oomen JA, Schuurbiers JC, Andhyiswara I, Kloet J, Post M, de Smet B, Borst C, Slager CJ and Serruys PW
Seminars in Interventional Cardiology vol. 3 (1), 39-44.  
01-03-1998
Cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Roelandt JRT and Bom N
European Journal of Ultrasound, Elsevier vol. 7 
01-02-1998
Decreased Coronary Flow Reserve in Hypertrophic Cardiomyopathy Is Related to Remodeling of the Coronary Microcirculation
Krams R, Kofflard MJM, Duncker DJ, Von Birgelen C, Carlier S, Kliffen M, Cate FJT and Serruys PW
Circulation, Wolters Kluwer vol. 97 (3), 230-233.  
27-01-1998
AT1 receptor A/C1166 polymorphism contributes to cardiac hypertrophy in subjects with hypertrophic cardiomyopathy
Osterop APRM, Kofflard MJM, Sandkuijl LA, Ten Cate FJ, Krams R, Schalekamp MADH and Danser AHJ
Hypertension vol. 32 (5), 825-830.  
01-01-1998

1997

Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Dongsheng FA, Kie Soei LO, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams ROB
American Journal of Physiology - Heart and Circulatory Physiology vol. 42 (5) 
01-12-1997
Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R
American Journal of Physiology, American Physiological Society vol. 273 (5), h2146-h2154.  
01-11-1997
Evaluation of Endothelial Shear Stress and 3D Geometry as Factors Determining the Development of Atherosclerosis and Remodeling in Human Coronary Arteries in Vivo
Krams R, Wentzel JJ, Oomen JAF, Vinke R, Schuurbiers JCH, de Feyter PJ, Serruys PW and Slager CJ
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 17 (10), 2061-2065.  
01-10-1997
Cardiac depression after experimental air embolism in pigs: role of addition of a surface-active agent1
van Blankenstein JH, Slager CJ, Soei LK, Boersma H, Stijnen T, Schuurbiers JCH, Krams R, Lachmann B and Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 34 (3), 473-482.  
01-06-1997
True reconstruction of vessel geometry from combined X-ray angiographic and intracoronary ultrasound data.
Slager CJ, Wentzel JJ, Oomen JA, Schuurbiers JC, Krams R, von Birgelen C, Tjon A, Serruys PW and de Feyter PJ
Seminars in Interventional Cardiology vol. 2 (1), 43-47.  
01-03-1997
Influence of data processing on cyclic variation of integrated backscatter and wall thickness in stunned porcine myocardium
van der Steen AFW, Rijsterborgh H, Lancée CT, Mastik F, Krams R, Verdouw PD, Roelandt JRTC and Bom N
Ultrasound in Medicine & Biology, Elsevier vol. 23 (3), 405-414.  
01-01-1997
Contribution of asynchrony and nonuniformity to mechanical interaction in normal and stunned myocardium
Fan D, Soei LK, Stubenitsky R, Boersma E, Duncker DJ, Verdouw PD and Krams R
American Journal of Physiology - Heart and Circulatory Physiology vol. 273 (5 42-5) 
01-01-1997

1996

The effect of a thiadiazinone derived Ca2+ sensitizer on the responsiveness of Mg2+-ATPase to Ca2+ in myofibrils isolated from stunned and nonstunned porcine and human myocardium
Bezstarosti K, Soei LK, Krams R, Cate FJT, Verdouw PD and Lamers JMJ
Biochemical Pharmacology, Elsevier vol. 51 (9), 1211-1220.  
01-05-1996
The relationship between myocardial integrated backscatter, perfusion pressure and wall thickness during isovolumic contraction: An isolated pig heart study
Rijsterborgh H, van der Steen AFW, Krams R, Mastik F, Lancee CT, Verdouw PD, Roelandt JRTC and Bom N
Ultrasound in Medicine & Biology, Elsevier vol. 22 (1), 43-52.  
01-01-1996

1995

New invasive techniques of assessment of the physiological significance of coronary stenoses in humans
Di Mario C, Gil R, Krams R, De Feyter PJ and Serruys W
European Heart Journal, Oxford University Press (Oup) vol. 16 (suppl_I), 104-114.  
01-08-1995
In Vivo Measurement of Regional Large Artery Compliance by Intravascular Ultrasound Under Pentobarbital Anesthesia
Wilson RA, Di Mario C, Krams R, Loe Kie Soei , Wenguang L, Laird AC, The SHK, Gussenhoven E, Verdouw P and Roelandt JRTC
Angiology, Sage Publications vol. 46 (6), 481-488.  
01-06-1995
Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency
Fan D
Cardiovascular Research, Oxford University Press (Oup) vol. 29 (3), 428-437.  
01-03-1995
734-6 ANGUS: A New Approach to Three-dimensional Reconstruction of Geometry and Orientation of Coronary Lumen and Plaque by Combined Use of Coronary Angiography and IVUS
Slager CJ, Laban M, von Birgelen C, Krams R, Oomen JAF, Boer AD, Wenguang L, de Feyter PJ, Serruys PW and Roelandt JRTC
Journal of The American College of Cardiology, Elsevier vol. 25 (2) 
01-02-1995

1994

Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 267 (4), h1557-h1564.  
01-10-1994
Slope of the instantaneous hyperemic diastolic coronary flow velocity-pressure relation. A new index for assessment of the physiological significance of coronary stenosis in humans.
Di Mario C, Krams R, Gil R and Serruys PW
Circulation, Wolters Kluwer vol. 90 (3), 1215-1224.  
01-09-1994
Mechanical efficiency of stunned myocardium is modulated by increased afterload dependency
Fan D, Soei LK, Sassen LM, Krams R and Verdouw PD
Cardiovascular Research vol. 28 (9), 428-437.  
01-09-1994
Myofibrillar Ca2+ sensitization predominantly enhances function and mechanical efficiency of stunned myocardium.
Soei LK, Sassen LM, Fan DS, van Veen T, Krams R and Verdouw PD
Circulation, Wolters Kluwer vol. 90 (2), 959-969.  
01-08-1994
On the Reversal of Myocardial Stunning: A Role for Ca2+‐Sensitizers
FAN D, SOEI LK, SASSEN LMA, KRAMS R, HENDRIK E and VERDOUW PD
Annals of The New York Academy of Sciences, Wiley vol. 723 (1), 364-367.  
01-06-1994
On the Reversal of Myocardial Stunning: A Role for Ca2+-Sensitizers.
Fan D, Kie Soei L, Sassen LMA, Krams R, Hendrik E and Verdouw PD
Ann N Y Acad Sci vol. 723 (1), 364-367.  
01-06-1994
Loss of elastic recoil in postischemic myocardium induces rightward shift of the systolic pressure-volume relationship
Krams R, Janssen M, Van der Lee C, Van Meegen J, De Jong JW, Slager CJ and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 267 (4 36-4) 
01-01-1994
Increasing the Ca++ sensitivity reverses the increased afterload dependency of external work and the efficiency of energy conversion of stunned myocardium
Fan D, Sassen LMA, Trines SAIP, Soei LK, Krams R and Verdouw PD
Applied Cardiopulmonary Pathophysiology vol. 5 (2), 63-72.  
01-01-1994
LOSS OF ELASTIC RECOIL IN POSTISCHEMIC MYOCARDIUM INDUCES RIGHTWARD SHIFT OF THE SYSTOLIC PRESSURE-VOLUME RELATIONSHIP
KRAMS R, JANSSEN M, VANDERLEE C, VANMEEGEN J, DEJONG JW, SLAGER CJ and VERDOUW PD
American Journal of Physiology-Heart and Circulatory Physiology vol. 267 (4), H1557-H1564.  
01-01-1994
The instantaneous hyperemic pressure-flow relationship in conscious humans
Di Mario C, Krams R, Gil R, Meneveau N and Serruys PW
In Progress in Quantitative Coronary Arteriography, Springer Nature 247-268.  
01-01-1994

1993

End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation
Krams R, Soei LK, McFalls EO, Prins EAW, Sassen LM and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 265 (6), h2099-h2109.  
01-12-1993
Intracoronary trimetazidine does not improve recovery of regional function in a porcine model of repeated ischemia
Koning MMG, Krams R, Xiao CS, van Meegen JR, Bezstarosti K, Lamers JMJ and Verdouw PD
Cardiovascular Drugs and Therapy, Springer Nature vol. 7 (5), 801-807.  
01-11-1993
L-Propionylcarnitine Does Not Affect Myocardial Metabolic or Functional Response to Chronotropic and Inotropic Stimulation After Repetitive Ischemia in Anesthetized Pigs
Duncker DJ, Sassen LMA, Bartels GL, van Meegen JR, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD
Journal of Cardiovascular Pharmacology, Wolters Kluwer vol. 22 (3), 488-498.  
01-09-1993
Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium
Krams R, Duncker DJ, McFalls EO, Hogendoorn A and Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 27 (5), 740-747.  
01-05-1993
Altered coronary flow reserve in the hypertrophied heart: implications for therapy.
McFalls EO, Duncker DJ, Sassen LM, Krams R, Man in't Veld AJ, Ruffolo RR and Verdouw PD
Journal of Human Hypertension vol. 7 Suppl 1, s29-s36.  
01-02-1993
END-SYSTOLIC PRESSURE LENGTH RELATIONS OF STUNNED RIGHT-AND-LEFT-VENTRICLES AFTER INOTROPIC STIMULATION
KRAMS R, SOEI LK, MCFALLS EO, PRINS EAW, SASSEN LMA and VERDOUW PD
American Journal of Physiology vol. 265 (6), H2099-H2109.  
01-01-1993
Dobutamine restores the reduced efficiency of energy transfer from total mechanical work to external mechanical work in stunned porcine myocardium
Krams R, Duncker DJ, McFalls EO, Hogendoorn A and Verdouw PD
Cardiovascular Research vol. 27 (5), 740-747.  
01-01-1993
End-systolic pressure length relations of stunned right and left ventricles after inotropic stimulation
Krams R, Loe Kie Soei , McFalls EO, Prins EAW, Sassen LMA and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 265 (6 34-6) 
01-01-1993
High-energy phosphates and their catabolites
De Jong JW, Huizer T, Janssen M, Krams R, Tavenier M and Verdouw PD
In Ischemia-Reperfusion in Cardiac Surgery, Springer Nature 295-315.  
01-01-1993

1992

Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium
McFalls EO, Duncker DJ, Krams R, Sassen LM, Hoogendoorn A and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 263 (6), h1724-h1731.  
01-12-1992
L-propionylcarnitine and myocardial performance in stunned porcine myocardium
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD
Molecular and Cellular Biochemistry, Springer Nature vol. 116 (1-2), 147-153.  
01-10-1992
Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium
Duncker DJ, McFalls EO, Krams R and Verdouw PD
American Journal of Physiology, American Physiological Society vol. 262 (6), h1744-h1751.  
01-06-1992
Amiodarone increases ATP and decreases NaK ATPase activity and protein content of cultured rat heart myocytes
Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A and Kie Soei L
Journal of Molecular and Cellular Cardiology, Elsevier vol. 24 
01-05-1992
Inotropic stimulation restores efficiency of energy transfer from pressure-segment length area to external mechanical work in stunned porcine myocardium
Verdouw PD, Krams R, McFalls EO, Duncker DJ, Hogendoorn A and Soei LK
Journal of Molecular and Cellular Cardiology, Elsevier vol. 24 
01-05-1992
Recruitment of myocardial work and metabolism in regionally stunned porcine myocardium
McFalls EO, Duncker DJ, Krams R, Sassen LMA, Hoogendoorn A and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 263 (6 32-6) 
01-01-1992
PRESSURE-MAXIMAL CORONARY FLOW RELATIONSHIP IN REGIONALLY STUNNED PORCINE MYOCARDIUM
DUNCKER DJ, MCFALLS EO, KRAMS R and VERDOUW PD
American Journal of Physiology vol. 262 (6), H1744-H1751.  
01-01-1992
Pressure-maximal coronary flow relationship in regionally stunned porcine myocardium
Duncker DJ, McFalls EO, Krams R and Verdouw PD
American Journal of Physiology - Heart and Circulatory Physiology vol. 262 (6 31-6) 
01-01-1992
RECRUITMENT OF MYOCARDIAL WORK AND METABOLISM IN REGIONALLY STUNNED PORCINE MYOCARDIUM
MCFALLS EO, DUNCKER DJ, KRAMS R, SASSEN LMA, HOOGENDOORN A and VERDOUW PD
American Journal of Physiology vol. 263 (6), H1724-H1731.  
01-01-1992
L-propionylcarnitine and myocardial performance in stunned porcine myocardium
Sassen LMA, Duncker DJ, Hogendoorn A, McFalls EO, Krams R, Bezstarosti K, Lamers JMJ and Verdouw PD
In Lipid Metabolism in The Healthy and Disease Heart, Springer Nature 147-153.  
01-01-1992

1991

Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
McFalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD
Cardiovascular Research, Oxford University Press (Oup) vol. 25 (8), 659-665.  
01-08-1991
Changes in oxygen-pressure volume area's (O2-PVA) studied after brief periods of ischemia
Krams R, Duncker DJ, McFalls EO and Verdouw PD
Journal of Molecular and Cellular Cardiology, Elsevier vol. 23 
01-07-1991
Elastic recoil: A sensitive measure of loss of function during brief periods of ischemia and reperfusion
Krams R, Duncker DJ, McFalls EO and Verdouw PD
Journal of Molecular and Cellular Cardiology, Elsevier vol. 23 
01-07-1991
Does intravenous milrinone have a direct effect on diastolic function?
Krams R, McFalls E, van der Giessen WJ, Serruys PW, Verdoun PD and Roelandt J
Am Heart J vol. 121 (6 Pt 2), 1951-1955.  
01-06-1991
Endothelium dependent vasodilatation following brief ischaemia and reperfusion in anaesthetised swine
Mcfalls EO, Duncker DJ, Krams R, Ward H, Gornick C and Verdouw PD
Cardiovascular Research vol. 25 (8), 659-665.  
01-01-1991

1990

Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FC
American Journal of Physiology, American Physiological Society vol. 259 (6), h1869-h1880.  
01-12-1990
Myocardial modulation of coronary circulation Reply)
Westerhof N, Sipkema P and Krams R
American Journal of Physiology - Heart and Circulatory Physiology vol. 259 (6 28-6) 
01-12-1990
Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
Krams R, Sipkema P and Westerhof N
American Journal of Physiology, American Physiological Society vol. 258 (6), h1889-h1898.  
01-06-1990
MYOCARDIAL MODULATION OF CORONARY CIRCULATION - REPLY
WESTERHOF N, SIPKEMA P and KRAMS R
American Journal of Physiology vol. 259 (6), H1936-H1937.  
01-01-1990
EFFECT OF WALL STRETCH ON CORONARY HEMODYNAMICS IN ISOLATED CANINE INTERVENTRICULAR SEPTUM
RESAR J, LIVINGSTON JZ, HALPERIN HR, SIPKEMA P, KRAMS R and YIN FCP
American Journal of Physiology vol. 259 (6), H1869-H1880.  
01-01-1990
CORONARY OSCILLATORY FLOW AMPLITUDE IS MORE AFFECTED BY PERFUSION-PRESSURE THAN VENTRICULAR PRESSURE
KRAMS R, SIPKEMA P and WESTERHOF N
American Journal of Physiology vol. 258 (6), H1889-H1898.  
01-01-1990
Effect of wall stretch on coronary hemodynamics in isolated canine interventricular septum
Resar J, Livingston JZ, Halperin HR, Sipkema P, Krams R and Yin FCP
American Journal of Physiology - Heart and Circulatory Physiology vol. 259 (6 28-6) 
01-01-1990
Coronary oscillatory flow amplitude is more affected by perfusion pressure than ventricular pressure
Krams R, Sipkema P and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 258 (6 27-6) 
01-01-1990

1989

Contractility is the main determinant of coronary systolic flow impediment
Krams R, Sipkema P, Zegers J and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 257 (6) 
01-12-1989
Varying elastance concept may explain coronary systolic flow impediment
Krams R, Sipkema P and Westerhof N
American Journal of Physiology, American Physiological Society vol. 257 (5), h1471-h1479.  
01-11-1989
Varying elastance concept may explain coronary systolic flow impediment.
Krams R, Sipkema P and Westerhof N
Am J Physiol vol. 257 (5 Pt 2), H1471-H1479.  
01-11-1989
Can coronary systolic-diastolic flow differences be predicted by left ventricular pressure or time-varying intramyocardial elastance?
Krams R, van Haelst ACTA, Sipkema P and Westerhof N
Basic Research in Cardiology, Springer Nature vol. 84 (2), 149-159.  
01-03-1989

1988

Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion
Van Dijk LC, Krams R, Sipkema P and Westerhof N
American Journal of Physiology, American Physiological Society vol. 255 (3), h476-h482.  
01-09-1988
Changes in coronary pressure-flow relation after transition from blood to Tyrode perfusion
Van Dijk LC, Krams R, Sipkema P and Westerhof N
American Journal of Physiology - Heart and Circulatory Physiology vol. 255 (3) 
01-01-1988

1986

Comments on Pressure and tone dependence of coronary diastolic input impedance and capacitance
Westerhof N and Krams R
American Journal of Physiology, American Physiological Society vol. 250 (2), h330-h331.  
01-02-1986
Comments on Pressure and tone dependence of coronary diastolic input impedance and capacitance.
Westerhof N and Krams R
Am J Physiol vol. 250 (2 Pt 2), H330-H331.  
01-02-1986
Comments on 'pressure and tone dependence of coronary diastolic input impedance and capacitance'
Westerhof N, Krams R and Canty JM
American Journal of Physiology - Heart and Circulatory Physiology vol. 250 (2 (19/2)) 
01-01-1986

1984

Consistent parallel relationships among myocardial oxygen consumption, coronary blood flow, and pericardial infusate adenosine concentration with various interventions and beta-blockade in the dog.
Borgdorff P, Braakman R, van Haelst AC, van Huis GA, de Jong JP, Krams R, Langewouters GJ, Sipkema P and Westerhof N
Circulation Research, Wolters Kluwer vol. 54 (3), 348-348.  
01-03-1984

1982

THE EFFECTS OF THE CORONARY CAPACITANCE ON THE INTERPRETATION OF DIASTOLIC PRESSURE-FLOW RELATIONSHIPS - COMMENTS
BRAAKMAN R, VANDERHORN GJ, VONHUIS GA, KRAMS R, LANGEWOUTERS GJ, SIPKEMA P and WESTERHOF N
Circulation Research vol. 51 (6), 822-822.  
01-01-1982

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconG1F1Application of a new high throughput platform for validation of mechanosensitive miRNA
Rob Krams and Gleb Sukhorukov
£117,986 BHF British Heart Foundation
01-09-2023 - 31-08-2026


bullet iconInorganic nitrate treatment reduces inflammation in humans: assessment of mechanisms
Amrita Ahluwalia, Rob Krams, Federica Marelli-Berg and Jacqueline Cooper
£206,297 BHF British Heart Foundation
19-08-2019 - 18-02-2022
bullet iconBiomechanical determinants of advanced coronary atherosclerotic plaque formation in transgenic hyperlipidaemic minipigs
Rob Krams
£167,563 BHF British Heart Foundation
01-11-2018 - 31-01-2021
bullet iconDisturbed shear stress and strain act synergistically to promote the pro-atherogenic endothelial cell phenotype responsible for TCFA - GRANT TRANSFER
Rob Krams
£46,226 BHF British Heart Foundation
01-02-2018 - 16-08-2018
bullet iconAliah Mohammed Ahmad Abuammah - Studentship
Rob Krams
£28,000 UKSACB Saudi Arabian Cultural Bureau in London
22-01-2018 - 12-01-2019