P15 Understanding the role of cathepsin H in atopic dermatitis pathogenesis
Tachie-Menson T, Hughes A, O’Toole E and O’Shaughnessy R
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e85-e86.  
17-05-2024

Loss-of-function FLG mutations are associated with reduced history of acne vulgaris in a cohort of patients with atopic eczema of Bangladeshi ancestry in East London
Hughes AJ, Barbosa E, Cernova J, Thomas BR, O’Shaughnessy RFL and O’Toole EA
Clinical and Experimental Dermatology, Oxford University Press (Oup) vol. 49 (12), 1547-1553.  
15-05-2024

Editorial: Novel aspects of the immunological and structural barrier of the epidermis
O’Shaughnessy R, Common J and Gutowska-Owsiak D
Frontiers in Molecular Biosciences, Frontiers vol. 10 
01-11-2023

Why are squamous cancers so aggressive in recessive dystrophic epidermolysis bullosa? Can we find new therapeutic approaches?
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (1), 7-8.  
13-10-2023

O14 Junctional epidermolysis bullosa: repairing the epidermal lipid barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O’Toole E and Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e10-e10.  
07-07-2023

P27 Uncovering the roles of lysosomal protease cathepsin H in atopic dermatitis
Tachie-Menson T, Azizah A, Hughes A and O'Shaughnessy R
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e24-e25.  
07-07-2023

P102 Severe atopic eczema is associated with reduced acne vulgaris in Bangladeshi children and young adults: a retrospective analysis from a cross-sectional study
Hughes A, Barbosa E, Cernova J, Thomas B, O’Toole E and O'Shaughnessy R
British Journal of Dermatology, Oxford University Press (Oup) vol. 188 (Supplement_4) 
26-06-2023

770 AKT1-dependent protease control of skin barrier function and inflammation in atopic dermatitis
Tachie-Menson T, Azizah A, Hughes A and O'Shaughnessy R
Journal of Investigative Dermatology, Elsevier vol. 143 (5) 
01-05-2023

1157 Ozone as an aggravating factor in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R and O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (5) 
01-05-2023

786 IL-4 stimulates IL-1R2 upregulation in atopic dermatitis keratinocytes
Baruah K, Koh L, Tham K, O'Shaughnessy R, O'Toole E and Common JE
Journal of Investigative Dermatology, Elsevier vol. 143 (5) 
01-05-2023

ISID1157 - Ozone as an aggravating factor in atopic eczema
Tawfik S, O'Toole E, Thomas B, Caley M, Jones E and O'Shaughnessy R
, Morressier 
29-04-2023

Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype
Tagoe H, Hassan S, Bliss E, Youssef G, Heywood W, Mills K, Harper JI and O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), 91-102.  
27-03-2023

191 Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O’Shaughnessy R, Aumailley M, McGrath JA, O’Toole EA and Caley MP
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022

183 Reduced FLG expression in atopic eczema reduces expression of key barrier genes and increases BMP signalling
Hughes AJ, Thomas B, O’Toole EA and O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022

174 Defining the composition and function of Lamin ribonuclear bodies during keratinocyte terminal differentiation and nuclear degradation
Wotherspoon DJ, Tachie-Menson T, Rogerson C and O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022

144 Carbonylated proteins and Ozone in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley MP, O’Shaughnessy R and O’Toole EA
Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022

ESDR144 - Carbonylated proteins and Ozone in atopic eczema
Tawfik S, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E and Prasad Baruah K
, Morressier 
26-09-2022

ESDR174 - Defining the composition and function of Lamin ribonuclear bodies during keratinocyte terminal differentiation and nuclear degradation
Wotherspoon D, Tachie-Menson T, Rogerson C and O'Shaughnessy R
, Morressier 
26-09-2022

ESDR191 - Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O'Toole E and Caley M
, Morressier 
22-09-2022

Understanding the paradoxical proinflammatory effects of an immunosuppressant
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 185 (6), 1091-1092.  
08-11-2021

111 Single cell RNA seq revealed altered cytoskeletal dynamics and the formation of cytoplasmic RNA-Lamin A bodies during keratinocyte terminal differentiation
Wotherspoon DJ, Rogerson C and O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier vol. 141 (10) 
01-10-2021

132 Increased BMP Signalling Correlates with Increased Eczema Severity
Hughes AJ, Thomas B, O’Toole EA and O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier vol. 141 (10) 
01-10-2021

282 Phosphoproteomic profiling of AKT-related changes in cutaneous squamous cell carcinoma identified DNA-dependent protein kinase (DNA-PK) and N-Myc downstream regulator 2 (NDRG2) as therapeutic vulnerabilities
Button R, Harwood C and O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier vol. 141 (10) 
01-10-2021

Ceramide kinase‐like protein, ‘the kinase that isn’t’, finds a role in skin cancer stress relief
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 185 (1), 14-15.  
23-03-2021

Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation
Wotherspoon D, Tommasi C, O'Shaughnessy R, Button R and Rogerson C
Cell Death and Differentiation, Springer Nature [Academic Journals On Nature.Com] 
18-01-2021

Tape Strips in Dermatology Research.
Hughes AJ, Tawfik SS, Baruah KP, O'Toole EA and O'Shaughnessy RFL
Br J Dermatol 
28-12-2020

Perspective: Controlling epidermal terminal differentiation with transcriptional bursting and RNA bodies
O'Shaughnessy R, Rogerson C and Wotherspoon D
Journal of Developmental Biology, Mdpi Ag vol. 8 (4) 
04-12-2020

Ubiquitin, a novel therapeutic target in psoriasis?
O'Shaughnessy R
British Journal of Dermatology, Wiley 
21-07-2020

Understanding actinic keratosis to reduce squamous cell carcinoma incidence.
O'Shaughnessy RFL
British Journal of Dermatology, Wiley 
16-10-2019

Kallikrein-mediated cytokeratin 10 degradation is required for VZV propagation in skin
Tommasi C, Rogerson C, Depledge DP, Jones M, Naeem AS, Venturini C, Frampton D, Tutill HJ, Way B, Breuer J and O'Shaughnessy RFL
Journal of Investigative Dermatology, Elsevier vol. 140 (Nat Biotech 34 2016), 774-784.e11.  
15-10-2019

Sonic Hedgehog-signalling limits chronic dermatitis via Gli2-driven immune regulatory function
O'Shaughnessy R and Papaioannou E
Journal of Clinical Investigation, American Society For Clinical Investigation 
02-07-2019

Targeting tryptophan transport and breakdown in basal cell carcinoma.
O'Shaughnessy RFL
Br J Dermatol vol. 180 (1), 16-17.  
01-01-2019

Differential expression of secreted factors SOSTDC1 and ADAMTS8 cause profibrotic changes in linear morphoea fibroblasts
O'SHAUGHNESSY RFL
British Journal of Dermatology, Wiley 
26-10-2018

Protein kinases involved in epidermal barrier formation: The AKT family and other animals.
Rogerson C and O'Shaughnessy RF
Exp Dermatol 
30-05-2018

Orchestrated control of filaggrin–actin scaffolds underpins cornification
Gutowska-Owsiak D, de La Serna JB, Fritzsche M, Naeem A, Podobas EI, Leeming M, Colin-York H, O’Shaughnessy R, Eggeling C and Ogg GS
Cell Death & Disease, Springer Nature vol. 9 (4) 
15-03-2018

Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues.
Rogerson C, Bergamaschi D and O'Shaughnessy RFL
Nucleus, 1-9.  
05-12-2017

Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas
Janus JM, O'Shaughnessy RFL, Harwood CA and Maffucci T
Cancers, Mdpi vol. 9 (7) 
11-07-2017

A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SAG, Moffatt M, Cookson WO, Harper JI, Di WL, Reinheckel T and O'Shaughnessy RFL
Journal of Allergy and Clinical Immunology vol. 139 (4), 1228-1241.  
01-04-2017

CD161⁺ Tconv and CD161⁺ treg share a transcriptional and functional phenotype despite limited overlap in TCRβ repertoire
Duurland CL, Brown CC, O'Shaughnessy RFL and Wedderburn LR
Frontiers in Immunology vol. 8 (MAR) 
06-03-2017

Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity
Zhu Y, Underwood J, Macmillan D, Shariff L, O'Shaughnessy R, Harper JI, Pickard C, Friedmann PS, Healy E and Di W-L
Journal of Allergy and Clinical Immunology, Elsevier vol. 140 (5), 1310-1322.e5.  
24-02-2017

Constitutive Autophagy and Nucleophagy during Epidermal Differentiation
Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP, Harwood CA, Byrne C, O'Shaughnessy RFL and Bergamaschi D
Journal of Investigative Dermatology vol. 136 (7), 1460-1470.  
01-07-2016

Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis
Thomas AC, Zeng Z, Rivière J-B, O’Shaughnessy R, Al-Olabi L, St.-Onge J, Atherton DJ, Aubert H, Bagazgoitia L, Barbarot S, Bourrat E, Chiaverini C, Chong WK, Duffourd Y, Glover M, Groesser L, Hadj-Rabia S, Hamm H, Happle R, Mushtaq I, Lacour J-P, Waelchli R, Wobser M, Vabres P, Patton EE and Kinsler VA
Journal of Investigative Dermatology, Elsevier vol. 136 (4), 770-778.  
14-01-2016

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation
Naeem AS, Zhu Y, Di WL, Marmiroli S and O'Shaughnessy RFL
Cell Death & Differentiation, Springer Nature vol. 22 (12), 2123-2132.  
05-06-2015

Insight from the Air–Skin Interface
O'Shaughnessy RFL and Brown SJ
Journal of Investigative Dermatology, Elsevier vol. 135 (2), 331-333.  
01-02-2015

A novel microdeletion in LOR causing autosomal dominant loricrin keratoderma
Kinsler VA, Drury S, Khan A, Waelchli R, Rukaite G, Barnicoat A, Lench N, Harper JI and O'Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 172 (1), 262-264.  
09-12-2014

CD161+ regulatory t cells in immune regulation
Duurland C, Brooks T, Hubank M, O'Shaughnessy R and Wedderburn L
Pediatric Rheumatology, Springer Nature vol. 12 (Suppl 1) 
01-09-2014

PReS-FINAL-1021: Further characterization of CD161+ regulatory t cells in health and disease
Duurland C, Chain G, O'Shaughnessy R, Pesenacker A and Wedderburn L
Pediatric Rheumatology, Springer Nature vol. 11 (Suppl 2) 
01-12-2013

The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin‐43 dephosphorlyation during epidermal barrier acquisition
Gerner L, Youssef G and O'Shaughnessy RFL
Experimental Dermatology, Wiley vol. 22 (11), 754-756.  
29-10-2013

Identifying a Hyperkeratosis Signature in Autosomal Recessive Congenital Ichthyosis: Mdm2 Inhibition Prevents Hyperkeratosis in a Rat ARCI Model
Youssef G, Ono M, Brown SJ, Kinsler VA, Sebire NJ, Harper JI and O'Shaughnessy RFL
Journal of Investigative Dermatology, Elsevier vol. 134 (3), 858-861.  
04-09-2013

Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition
Youssef G, Gerner L, Naeem AS, Ralph O, Ono M, O’Neill CA and O’Shaughnessy RFL
Developmental Biology, Elsevier vol. 380 (2), 274-285.  
16-05-2013

T-Cell Reconstitution after Thymus Xenotransplantation Induces Hair Depigmentation and Loss
Furmanski AL, O'Shaughnessy RFL, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG and Crompton T
Journal of Investigative Dermatology, Elsevier vol. 133 (5), 1221-1230.  
10-01-2013

Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis
O'Shaughnessy RFL, Chaudhury I and Harper JI
Human Molecular Genetics, Oxford University Press (Oup) vol. 22 (5), 1059-1059.  
18-12-2012

The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
Sully K, Akinduro O, Philpott MP, Naeem AS, Harwood CA, Reeve VE, O'Shaughnessy RF and Byrne C
Oncogene, Springer Nature vol. 32 (27), 3254-3262.  
13-08-2012

AKT1 Loss Correlates with Episomal HPV16 in Vulval Intraepithelial Neoplasia
Ekeowa-Anderson AL, Purdie KJ, Gibbon K, Byrne CR, Arbeit JM, Harwood CA and O'Shaughnessy RFL
Plos One, Public Library of Science (Plos) vol. 7 (6) 
01-01-2012

TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML and Byrne C
Development vol. 138 (11), 1681-1690.  
01-06-2011

TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier.
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML and Byrne C
J Cell Sci vol. 124 (Pt 10), 1681-1690.  
15-05-2011

Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis
O'Shaughnessy RFL, Choudhary I and Harper JI
Human Molecular Genetics, Oxford University Press (Oup) vol. 19 (13), 2594-2605.  
12-04-2010

Whole-mount assays for gene induction and barrier formation in the developing epidermis.
Byrne C, Avilion AA, O'Shaughnessy RF, Welti JC and Hardman MJ
Methods Mol Biol vol. 585, 271-286.  
01-01-2010

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development.
O'Shaughnessy RFL, Welti JC, Sully K and Byrne C
Development vol. 136 (20), 3423-3431.  
01-10-2009

Cutaneous human papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors.
O'Shaughnessy RFL, Akgũl B, Storey A, Pfister H, Harwood CA and Byrne C
Cancer Res vol. 67 (17), 8207-8215.  
01-09-2007

AKT-dependent HspB1 (Hsp27) activity in epidermal differentiation.
O'Shaughnessy RFL, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ and Byrne C
J Biol Chem vol. 282 (23), 17297-17305.  
08-06-2007

The WNT signalling modulator, Wise, is expressed in an interaction-dependent manner during hair-follicle cycling.
O'Shaughnessy RFL, Yeo W, Gautier J, Jahoda CAB and Christiano AM
J Invest Dermatol vol. 123 (4), 613-621.  
01-10-2004

The role of BMP signalling in the control of ID3 expression in the hair follicle
O'Shaughnessy RFL, Christiano AM and Jahoda CAB
Experimental Dermatology, Wiley vol. 13 (10), 621-629.  
24-09-2004

The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene
Jahoda CAB, Kljuic A, O'Shaughnessy R, Crossley N, Whitehouse CJ, Robinson M, Reynolds AJ, Demarchez M, Porter RM, Shapiro L and Christiano AM
Genomics, Elsevier vol. 83 (5), 747-756.  
01-05-2004

Inherited disorders of the skin in human and mouse: from development to differentiation.
O'Shaughnessy RFL and Christiano AM
The International Journal of Developmental Biology, Upv/Ehu Press vol. 48 (2-3), 171-179.  
01-01-2004

Desmoglein 4 in Hair Follicle Differentiation and Epidermal Adhesion Evidence from Inherited Hypotrichosis and Acquired Pemphigus Vulgaris
Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X, Ahmad W, Aita VM, Gordon D, Uitto J, Whiting D, Ott J, Fischer S, Gilliam TC, Jahoda CAB, Morris RJ, Panteleyev AA, Nguyen VT and Christiano AM
Cell, Elsevier vol. 113 (2), 249-260.  
01-04-2003

Analysis of Gene Expression Using High-Density and IFN-γ-Specific Low-Density cDNA Arrays
Aberger F, Costa-Pereira AP, Schlaak JF, Williams TM, O'Shaughnessy RFL, Hollaus G, Kerr IM and Frischauf A-MM
Genomics, Elsevier vol. 77 (1-2), 50-57.  
01-09-2001

Stem Cells in the Epidermis
O’Shaughnessy RFL and Christiano AM
Skin Pharmacology and Physiology, Karger Publishers vol. 14 (6), 350-357.  
01-01-2001

PA‐FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation
O'Shaughnessy RFL, Seery JP, Celis JE, Frischauf A-M and Watt FM
Febs Letters, Wiley vol. 486 (2), 149-154.  
07-12-2000