Dr Suzanne Eldridge
Senior Lecturer of Musculoskeletal Regenerative Medicine
The William Harvey Research Institute
Queen Mary University London
Queen Mary University London
Research
Cartilage, Osteoarthritis, Pain, Drug development
Interests
In vitro (micromass 3D culture) and ex vivo (explants, joint on a chip) models of cartilage regeneration, degeneration, injury and diseasePublications
Publications of specific relevance to Predictive in vitro Models
2022
Caxaria S, Kouvatsos N, Eldridge SE, Alvarez-Fallas M, Thorup A-S, Cici D, Barawi A, Arshed A, Strachan D, Carletti G, Huang X, Bharde S, DENIZ M, Wilson J, Thomas BL, Pitzalis C, Cantatore FP, Sayilekshmy M, Sikandar S, Luyten F, Pap T, Sherwood J, Day A and Dell'Accio F (2022). Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine. EMBO Press EMBO Molecular Medicine
Thorup A-S, Dell’Accio F and Eldridge SE (2022). A Mouse Model of Acute Cartilage Injury and Repair. Springer Nature Methods in Molecular Biology vol. 2598, 337-344.
Eldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M, Lydon H, Henson F, De Bari C, McCaskie A and Dell’Accio F (2022). AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS. Elsevier Annals of the Rheumatic Diseases vol. 81, (Suppl 1) 1208.1-121208.
Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J, Pitzalis C, Aigner T, Corder R, Bertrand J, Lohmander S, Cutillas P and Dell'Accio F (2022). BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING. Elsevier Osteoarthritis and Cartilage vol. 30,
THORUP A, Caxaria S, Dell'Accio F, Thomas BL, Suleman Y, Nalesso G, Luyten FP, Dell'Accio F and Eldridge SE (2022). In vivo potency assay for the screening of bioactive molecules on cartilage formation. Nature Research Lab Animal
2021
Thomas B, Eldridge S, Nosrati B, Alvarez M, THORUP A-S, Nalesso G, Caxaria S, Barawi A, Nicholson J, Perretti M, Gaston-Massuet C, Pitzalis C, Maloney A, Moore A, Jupp R and Dell'Accio F (2021). WNT3A-loaded exosomes enable cartilage repair. Co-Action Publishing Journal of Extracellular Vesicles
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, Mccaskie A, De Bari C and Dell’accio F (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. Annals of the Rheumatic Diseases vol. 80, (Suppl 1) 1052.1-101052.
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J, Pitzalis C, Aigner T, Corder R, Bertrand J and Dell’accio F (2021). OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS. Elsevier Annals of the Rheumatic Diseases vol. 80, (Suppl 1) 120.1-12121.
Nalesso G, Thorup A-S, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S, Stott B, Vincent TL, Thomas BL, Bertrand J, Sherwood J, Fioravanti A, Pitzalis C and Dell’Accio F (2021). Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. Springer Nature Scientific Reports vol. 11, (1)
2020
Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J, Pitzalis C, Agner T, Corder R, Bertrand J and Dell'Accio F (2020). ROR2 blockade as a therapy for osteoarthritis. American Association for the Advancement of Science Science Translational Medicine vol. 12, (561)
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. American Association for the Advancement of Science Science Translational Medicine vol. 12, (559)
Thorup A, Dell'Accio F and Eldridge SE (2020). Lessons from joint development for cartilage repair in the clinic. Wiley Developmental Dynamics vol. 250, (3) 360-376.
2018
Pengas I, Eldridge S, Assiotis A, McNicholas M, Mendes JE and Laver L (2018). MMP‐3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy. Wiley Journal of Experimental Orthopaedics vol. 5, (1)
2016
nalesso , thomas , sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup , Dale L, Schett G, Jochen Z, Eltawil N, Pitzalis and Dell''accio (2016). WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. Annals of Rheumatic Diseases
2015
Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J, Pitzalis C, Perretti M and Dell'Accio F (2015). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Elsevier Annals of the Rheumatic Diseases vol. 75, (6)
2014
Sherwood JC, Bertrand J, Eldridge SE and Dell’Accio F (2014). Cellular and molecular mechanisms of cartilage damage and repair. Elsevier Drug Discovery Today vol. 19, (8) 1172-1177.
2013
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P and Dell'Accio F (2013). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. Elsevier Osteoarthritis and Cartilage vol. 21, s112-s113.