Dr Suzanne Eldridge

Suzanne Eldridge

Senior Lecturer of Musculoskeletal Regenerative Medicine

The William Harvey Research Institute
Queen Mary University London

Research

Cartilage, Osteoarthritis, Pain, Drug development

Interests

In vitro (micromass 3D culture) and ex vivo (explants, joint on a chip) models of cartilage regeneration, degeneration, injury and disease

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2022

Caxaria S, Kouvatsos N, Eldridge SE, Alvarez-Fallas M, Thorup A-S, Cici D, Barawi A, Arshed A, Strachan D, Carletti G, Huang X, Bharde S, DENIZ M, Wilson J, Thomas BL, Pitzalis C, Cantatore FP, Sayilekshmy M, Sikandar S, Luyten F, Pap T, Sherwood J, Day A and Dell'Accio F (2022). Disease modification and symptom relief in osteoarthritis using a mutated GCP-2/CXCL6 chemokine. EMBO Press  EMBO Molecular Medicine   
Thorup A-S, Dell’Accio F and Eldridge SE (2022). A Mouse Model of Acute Cartilage Injury and Repair. Springer Nature  Methods in Molecular Biology  vol. 2598, 337-344.  
Eldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M, Lydon H, Henson F, De Bari C, McCaskie A and Dell’Accio F (2022). AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS. Elsevier  Annals of the Rheumatic Diseases  vol. 81, (Suppl 1) 1208.1-121208.  
Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J, Pitzalis C, Aigner T, Corder R, Bertrand J, Lohmander S, Cutillas P and Dell'Accio F (2022). BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING. Elsevier  Osteoarthritis and Cartilage  vol. 30,  
THORUP A, Caxaria S, Dell'Accio F, Thomas BL, Suleman Y, Nalesso G, Luyten FP, Dell'Accio F and Eldridge SE (2022). In vivo potency assay for the screening of bioactive molecules on cartilage formation. Nature Research  Lab Animal   

2021

Thomas B, Eldridge S, Nosrati B, Alvarez M, THORUP A-S, Nalesso G, Caxaria S, Barawi A, Nicholson J, Perretti M, Gaston-Massuet C, Pitzalis C, Maloney A, Moore A, Jupp R and Dell'Accio F (2021). WNT3A-loaded exosomes enable cartilage repair. Co-Action Publishing  Journal of Extracellular Vesicles   
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, Mccaskie A, De Bari C and Dell’accio F (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. Annals of the Rheumatic Diseases  vol. 80, (Suppl 1) 1052.1-101052.  
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J, Pitzalis C, Aigner T, Corder R, Bertrand J and Dell’accio F (2021). OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS. Elsevier  Annals of the Rheumatic Diseases  vol. 80, (Suppl 1) 120.1-12121.  
Nalesso G, Thorup A-S, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S, Stott B, Vincent TL, Thomas BL, Bertrand J, Sherwood J, Fioravanti A, Pitzalis C and Dell’Accio F (2021). Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis. Springer Nature  Scientific Reports  vol. 11, (1)  

2020

Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J, Pitzalis C, Agner T, Corder R, Bertrand J and Dell'Accio F (2020). ROR2 blockade as a therapy for osteoarthritis. American Association for the Advancement of Science  Science Translational Medicine  vol. 12, (561)  
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. American Association for the Advancement of Science  Science Translational Medicine  vol. 12, (559)  
Thorup A, Dell'Accio F and Eldridge SE (2020). Lessons from joint development for cartilage repair in the clinic. Wiley  Developmental Dynamics  vol. 250, (3) 360-376.  

2018

Pengas I, Eldridge S, Assiotis A, McNicholas M, Mendes JE and Laver L (2018). MMP‐3 in the peripheral serum as a biomarker of knee osteoarthritis, 40 years after open total knee meniscectomy. Wiley  Journal of Experimental Orthopaedics  vol. 5, (1)  

2016

nalesso , thomas , sherwood JC, Yu J, Addimanda O, Eldridge SE, Thorup , Dale L, Schett G, Jochen Z, Eltawil N, Pitzalis and Dell''accio (2016). WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis. Annals of Rheumatic Diseases   

2015

Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J, Pitzalis C, Perretti M and Dell'Accio F (2015). Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo. Elsevier  Annals of the Rheumatic Diseases  vol. 75, (6)  

2014

Sherwood JC, Bertrand J, Eldridge SE and Dell’Accio F (2014). Cellular and molecular mechanisms of cartilage damage and repair. Elsevier  Drug Discovery Today  vol. 19, (8) 1172-1177.  

2013

Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P and Dell'Accio F (2013). Agrin expression is downregulated in OA and is required for chondrocyte differentiation. Elsevier  Osteoarthritis and Cartilage  vol. 21, s112-s113.