Prof Susana Godinho
Principal Investigator
Research
cancer biology, cytoskeleton, cell migration and invasion, microenviroment, centrosome, cell
Interests
Our lab is interested in 3D culture models that better recapitulate different aspects of cell physiology relevant to study cancer. These include 3D spheroid co-culture, 2D micropatterning. We have a strong expertise in confocal imaging to take the most out of in vitro model system. We are particularly interested in models that incorporate different cellular components of the tumour microenvironment to study complex cell-cell interactions and invasion.Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2023
The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing.Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi M, Grevitt P, Madeeha S, Egle S, Godinho S, Bombardieri M, Smith D, Cooper D, Asif I, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD and Marelli-Berg F
, Editors: Figliuolo ML. Nature Metabolism, Nature Research
26-10-2023
Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organizationMonteiro P, Yeon B, Wallis SS and Godinho SA
The Embo Journal, Springer Nature vol. 42 (16)
05-07-2023
Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin openingHayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S, Cutillas P, Mohammed H, Grose RP and Ficz G
Disease Models & Mechanisms, The Company of Biologists vol. 16 (2)
01-02-2023
2022
Too close for comfort? Endomembranes promote missegregation by enclosing lost chromosomesDonker L and Godinho SA
Journal of Cell Biology, Rockefeller University Press vol. 221 (6)
10-05-2022
2021
Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruptionAdams SD, Csere J, D’angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F and Godinho SA
Current Biology, Elsevier vol. 31 (7), 1403-1416.e7.
15-02-2021
2020
Centrosome amplification mediates small extracellular vesicles secretion via lysosome disruptionAdams SD, Csere J, D’angelo G, Carter EP, Arnandis T, Dodel M, Kocher H, Grose R, Raposo G, Mardakheh F and Godinho SA
, Cold Spring Harbor Laboratory
20-08-2020
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathwayWilcz‐Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala‐Dilke K and Bianchi K
Embo Molecular Medicine, Springer Nature vol. 12 (2)
13-01-2020
2019
Early Career Advisory Board: Q&A on career and publishingMarat A
Journal of Cell Biology, Rockefeller University Press vol. 218 (9), 2815-2818.
22-08-2019
Early Career Advisory BoardJournal of Cell Biology, Rockefeller University Press vol. 218 (9), 2813-2814.
22-08-2019
The principles of spindle bipolarityGodinho SA
Nature Reviews Molecular Cell Biology, Springer Nature vol. 20 (6), 325-325.
24-04-2019
2018
Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous InvasionArnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C, Malanchi I, Cutillas PR and Godinho SA
Developmental Cell, Elsevier vol. 47 (4), 409-424.e9.
01-11-2018
Structural Centrosomal Abnormalities Push Cells toward InvasionMonteiro P and Godinho SA
Developmental Cell, Elsevier vol. 45 (3), 286-288.
01-05-2018
Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregationMarteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA and Bettencourt-Dias M
Nature Communications, Springer Nature vol. 9 (1)
28-03-2018
Cell scientist to watch – Susana GodinhoJournal of Cell Science, The Company of Biologists vol. 131 (4)
14-02-2018
2017
Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells.Rhys AD, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, Leitinger B, Sahai E, McAinsh A, Charras G and Godinho SA
J Cell Biol, Rockefeller University Press vol. 217 (1), 195-209.
13-11-2017
Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells.Rhys AD and Godinho SA
Adv Exp Med Biol, Springerlink vol. 1002, 47-67.
10-06-2017
Centrosomes: PIDDosome Joins the Counting GameGodinho S
Current Biology, Elsevier vol. 27 (6), r237-r239.
01-03-2017
2015
Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomesGibbons JG, Branco AT, Godinho SA, Yu S and Lemos B
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 112 (8), 2485-2490.
12-01-2015
Chapter 3 Studying centrosome function using three-dimensional cell culturesArnandis T and Godinho SA
Methods in Cell Biology, Elsevier vol. 129, 37-50.
01-01-2015
2014
Centrosome amplification and cancer: Branching outGodinho SA
Molecular & Cellular Oncology, Taylor & Francis vol. 2 (1)
01-12-2014
Causes and consequences of centrosome abnormalities in cancer.Godinho SA and Pellman D
Philos Trans R Soc Lond B Biol Sci vol. 369 (1650)
05-09-2014
Oncogene-like induction of cellular invasion from centrosome amplification.Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M and Pellman D
Nature vol. 510 (7503), 167-171.
05-06-2014
2012
The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers.Calado DP, Sasaki Y, Godinho SA, Pellerin A, Köchert K, Sleckman BP, de Alborán IM, Janz M, Rodig S and Rajewsky K
Nat Immunol vol. 13 (11), 1092-1100.
01-11-2012
2011
Centrosomes and cilia in human disease.Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G and Godinho SA
Trends Genet vol. 27 (8), 307-315.
01-08-2011
2010
Cytokinesis Failure In Fanconi Anemia Pathway Deficient Hematopoietic CellsParmar K, Vinciguerra P, Godinho S, Hamilton A, Pellman D and D'Andrea AD
Blood, American Society of Hematology vol. 116 (21)
19-11-2010
Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells.Vinciguerra P, Godinho SA, Parmar K, Pellman D and D'Andrea AD
J Clin Invest vol. 120 (11), 3834-3842.
01-11-2010
2009
Cytokinesis Failure in Fanconi Anemia Pathway Deficient Murine Hematopoietic Stem Cells.Vinciguerra P, Godinho S, Parmar K, Pellman D and D'Andrea A
Blood, American Society of Hematology vol. 114 (22)
20-11-2009
A mechanism linking extra centrosomes to chromosomal instability.Ganem NJ, Godinho SA and Pellman D
Nature vol. 460 (7252), 278-282.
09-07-2009
Centrosomes and cancer: how cancer cells divide with too many centrosomes.Godinho SA, Kwon M and Pellman D
Cancer Metastasis Rev vol. 28 (1-2), 85-98.
01-06-2009
2008
Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes.Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M and Pellman D
Genes Dev vol. 22 (16), 2189-2203.
15-08-2008
A role for Drosophila Polo protein in chromosome resolution and segregation during mitosis.Godinho S and Tavares AA
Cell Cycle vol. 7 (16), 2529-2534.
15-08-2008
2007
Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors.Schüller U, Zhao Q, Godinho SA, Heine VM, Medema RH, Pellman D and Rowitch DH
Mol Cell Biol vol. 27 (23), 8259-8270.
01-12-2007
2006
Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis.Pearson J, Godinho SA, Tavares A and Glover DM
Exp Cell Res vol. 312 (6), 770-781.
01-04-2006
The Drosophila orthologue of xPlkk1 is not essential for Polo activation and is necessary for proper contractile ring formation.Alves PS, Godinho SA and Tavares AA
Exp Cell Res vol. 312 (3), 308-321.
01-02-2006
Grants
Grants of specific relevance to Predictive in vitro Models
Dissecting the role of tubulin acetylation in DNA repair to improve response to PARPiSusana Godinho
£641,270 MRC Medical Research Council
29-07-2024 - 29-07-2027
The Role of Microtubule Acetylation in SASP ModulationSusana Godinho
£471,382 Wellcome Trust
08-01-2024 - 07-01-2028
Exploiting radiation to improve the outcome of centrosome-based therapiesSusana Godinho
£146,895 CR-UK Cancer Research UK
27-09-2021 - 26-09-2025
Investigating the impact of amplified centrosomes in cancerSusana Godinho
£1,489,238 CR-UK Cancer Research UK
01-06-2021 - 31-05-2027
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023
Super-Resolution Microscopy of live cells in 3DViji Draviam Sastry, Conrad Mullineaux, Vidya Darbari, Lakxmi Subramanian, Fabrice Caudron, Richard Pickersgill, Guy Hanke, Alexander Ruban, Peter Thorpe, Christopher Duffy, Jose Martin Duran, John Connelly, Peter McCormick, Paul Chapple, Vardhman Rakyan, Tyson Sharp, Susana Godinho and David Lee
£369,201 BBSRC Biotechnology and Biological Sciences Research Council
01-12-2020 - 31-03-2022
Dissecting the role of exosomes on the remodelling of PDAC microenvironmentSusana Godinho
£40,006 Barts and the London Charity
01-04-2020 - 31-03-2022
Dissecting the role of extra centrosomes-induced exosome secretion in PDAC microenvironmentSusana Godinho
£477,197 MRC Medical Research Council
01-12-2019 - 30-11-2023
CENTROSOTME - The role of extra centrosomes on the tumour microenvironmentSusana Godinho
£158,991 EU Commission - Horizon 2020
01-06-2019 - 12-04-2021
Non-Clinical Training Award , Cycle 4, 2018 (Hale, Close and Yeon)Nicholas Lemoine, Ivana Sestak, Jude Fitzgibbon and Susana Godinho
£297,105 CR-UK Cancer Research UK
01-10-2018 - 30-09-2022
Lister Institute Research Fellowship Prize - 2016Susana Godinho
£199,974 Lister Institute of Preventive Medicine, The
01-10-2016 - 30-09-2024