Prof Susana Godinho
Principal Investigator
Research
cancer biology, cytoskeleton, cell migration and invasion, microenviroment, centrosome, cell
Interests
Our lab is interested in 3D culture models that better recapitulate different aspects of cell physiology relevant to study cancer. These include 3D spheroid co-culture, 2D micropatterning. We have a strong expertise in confocal imaging to take the most out of in vitro model system. We are particularly interested in models that incorporate different cellular components of the tumour microenvironment to study complex cell-cell interactions and invasion.Publications
Publications of specific relevance to Predictive in vitro Models2023
Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M, Lucchesi D, Coleby R, Tarussio D, Thorens B, Hearnden RJ, Longhi M, Grevitt P, Madeeha S, Egle S, Godinho S, Bombardieri M, Smith D, Cooper D, Asif I, Rathmell JC, Schaefer S, Morales V, Bianchi K, Norata GD and Marelli-Berg F (2023). The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing., Editors: Figliuolo ML. Nature Research Nature Metabolism Monteiro P, Yeon B, Wallis SS and Godinho SA (2023). Centrosome amplification fine tunes tubulin acetylation to differentially control intracellular organization. Springer Nature The EMBO Journal vol. 42, (16) 
Hayat A, Carter EP, King HW, Ors A, Doe A, Teijeiro SA, Charrot S, Godinho S, Cutillas P, Mohammed H, Grose RP and Ficz G (2023). Low HER2 enables dedifferentiation and transformation of normal breast epithelial cells via chromatin opening. The Company of Biologists Disease Models & Mechanisms vol. 16, (2) 2022
Donker L and Godinho SA (2022). Too close for comfort? Endomembranes promote missegregation by enclosing lost chromosomes. Rockefeller University Press Journal of Cell Biology vol. 221, (6) 2021
Adams SD, Csere J, D’angelo G, Carter EP, Romao M, Arnandis T, Dodel M, Kocher HM, Grose R, Raposo G, Mardakheh F and Godinho SA (2021). Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption. Elsevier Current Biology vol. 31, (7) 1403-1416.e7. 2020
Adams SD, Csere J, D’angelo G, Carter EP, Arnandis T, Dodel M, Kocher H, Grose R, Raposo G, Mardakheh F and Godinho SA (2020). Centrosome amplification mediates small extracellular vesicles secretion via lysosome disruption. Cold Spring Harbor Laboratory Wilcz‐Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala‐Dilke K and Bianchi K (2020). Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. Springer Nature EMBO Molecular Medicine vol. 12, (2) 2019
Marat A (2019). Early Career Advisory Board: Q&A on career and publishing. Rockefeller University Press Journal of Cell Biology vol. 218, (9) 2815-2818. (2019). Early Career Advisory Board. Rockefeller University Press Journal of Cell Biology vol. 218, (9) 2813-2814. Godinho SA (2019). The principles of spindle bipolarity. Springer Nature Nature Reviews Molecular Cell Biology vol. 20, (6) 325-325. 2018
Arnandis T, Monteiro P, Adams SD, Bridgeman VL, Rajeeve V, Gadaleta E, Marzec J, Chelala C, Malanchi I, Cutillas PR and Godinho SA (2018). Oxidative Stress in Cells with Extra Centrosomes Drives Non-Cell-Autonomous Invasion. Elsevier Developmental Cell vol. 47, (4) 409-424.e9. Monteiro P and Godinho SA (2018). Structural Centrosomal Abnormalities Push Cells toward Invasion. Elsevier Developmental Cell vol. 45, (3) 286-288. Marteil G, Guerrero A, Vieira AF, de Almeida BP, Machado P, Mendonça S, Mesquita M, Villarreal B, Fonseca I, Francia ME, Dores K, Martins NP, Jana SC, Tranfield EM, Barbosa-Morais NL, Paredes J, Pellman D, Godinho SA and Bettencourt-Dias M (2018). Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation. Springer Nature Nature Communications vol. 9, (1) (2018). Cell scientist to watch – Susana Godinho. The Company of Biologists Journal of Cell Science vol. 131, (4) 2017
Rhys AD, Monteiro P, Smith C, Vaghela M, Arnandis T, Kato T, Leitinger B, Sahai E, McAinsh A, Charras G and Godinho SA (2017). Loss of E-cadherin provides tolerance to centrosome amplification in epithelial cancer cells. Rockefeller University Press J Cell Biol vol. 217, (1) 195-209. Rhys AD and Godinho SA (2017). Dividing with Extra Centrosomes: A Double Edged Sword for Cancer Cells. SpringerLink Adv Exp Med Biol vol. 1002, 47-67. Godinho S (2017). Centrosomes: PIDDosome Joins the Counting Game. Elsevier Current Biology vol. 27, (6) r237-r239. 2015
Gibbons JG, Branco AT, Godinho SA, Yu S and Lemos B (2015). Concerted copy number variation balances ribosomal DNA dosage in human and mouse genomes. Proceedings of the National Academy of Sciences Proceedings of the National Academy of Sciences of the United States of America vol. 112, (8) 2485-2490. Arnandis T and Godinho SA (2015). Chapter 3 Studying centrosome function using three-dimensional cell cultures. Elsevier Methods in Cell Biology vol. 129, 37-50. 2014
Godinho SA (2014). Centrosome amplification and cancer: Branching out. Taylor & Francis Molecular & Cellular Oncology vol. 2, (1) Godinho SA and Pellman D (2014). Causes and consequences of centrosome abnormalities in cancer. Philos Trans R Soc Lond B Biol Sci vol. 369, (1650) Godinho SA, Picone R, Burute M, Dagher R, Su Y, Leung CT, Polyak K, Brugge JS, Théry M and Pellman D (2014). Oncogene-like induction of cellular invasion from centrosome amplification. Nature vol. 510, (7503) 167-171. 2012
Calado DP, Sasaki Y, Godinho SA, Pellerin A, Köchert K, Sleckman BP, de Alborán IM, Janz M, Rodig S and Rajewsky K (2012). The cell-cycle regulator c-Myc is essential for the formation and maintenance of germinal centers. Nat Immunol vol. 13, (11) 1092-1100. 2011
Bettencourt-Dias M, Hildebrandt F, Pellman D, Woods G and Godinho SA (2011). Centrosomes and cilia in human disease. Trends Genet vol. 27, (8) 307-315. 2010
Parmar K, Vinciguerra P, Godinho S, Hamilton A, Pellman D and D'Andrea AD (2010). Cytokinesis Failure In Fanconi Anemia Pathway Deficient Hematopoietic Cells. American Society of Hematology Blood vol. 116, (21) Vinciguerra P, Godinho SA, Parmar K, Pellman D and D'Andrea AD (2010). Cytokinesis failure occurs in Fanconi anemia pathway-deficient murine and human bone marrow hematopoietic cells. J Clin Invest vol. 120, (11) 3834-3842. 2009
Vinciguerra P, Godinho S, Parmar K, Pellman D and D'Andrea A (2009). Cytokinesis Failure in Fanconi Anemia Pathway Deficient Murine Hematopoietic Stem Cells. American Society of Hematology Blood vol. 114, (22) Ganem NJ, Godinho SA and Pellman D (2009). A mechanism linking extra centrosomes to chromosomal instability. Nature vol. 460, (7252) 278-282. Godinho SA, Kwon M and Pellman D (2009). Centrosomes and cancer: how cancer cells divide with too many centrosomes. Cancer Metastasis Rev vol. 28, (1-2) 85-98. 2008
Kwon M, Godinho SA, Chandhok NS, Ganem NJ, Azioune A, Thery M and Pellman D (2008). Mechanisms to suppress multipolar divisions in cancer cells with extra centrosomes. Genes Dev vol. 22, (16) 2189-2203. Godinho S and Tavares AA (2008). A role for Drosophila Polo protein in chromosome resolution and segregation during mitosis. Cell Cycle vol. 7, (16) 2529-2534. 2007
Schüller U, Zhao Q, Godinho SA, Heine VM, Medema RH, Pellman D and Rowitch DH (2007). Forkhead transcription factor FoxM1 regulates mitotic entry and prevents spindle defects in cerebellar granule neuron precursors. Mol Cell Biol vol. 27, (23) 8259-8270. 2006
Pearson J, Godinho SA, Tavares A and Glover DM (2006). Heterologous expression of mammalian Plk1 in Drosophila reveals divergence from Polo during late mitosis. Exp Cell Res vol. 312, (6) 770-781. Alves PS, Godinho SA and Tavares AA (2006). The Drosophila orthologue of xPlkk1 is not essential for Polo activation and is necessary for proper contractile ring formation. Exp Cell Res vol. 312, (3) 308-321.