Prof Steffi Krause
Professor of Electroanalytical Systems
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
electrochemistry, photoelectrochemical imaging, functional cell imaging, biosensors
Interests
Our group has developed a photoelectrochemical imaging system for functional imaging of cellular processes in real time and with subcellular resolution. Our measurement technology has been shown to be sensitive to the surface charges and the permeability of cell membranes of cells in culture and is also capable of monitoring the concentrations of ions released by cells.Publications
Publications of specific relevance to Predictive in vitro Models2024
Welden R, Das A, Krause S, Schöning MJ, Wagner PH and Wagner T (2024). Actively Driven Light-Addressable Sensor/Actuator System for Automated pH Control for the Integration in Lab-On-A-Chip (LoC) Platforms. American Chemical Society (ACS) ACS Sensors vol. 9, (3) 1533-1544. 2023
Gorecki J and Krause S (2023). Numerical investigation of a graphene-on-semiconductor device for optical monitoring of cell electrophysiology. Elsevier iScience vol. 27, (1) 2022
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S (2022). Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids. Elsevier Biosensors and Bioelectronics Krause S (2022). High-resolution impedance and potential imaging using light-addressable potentiometric sensors for bio-imaging applications. Zhou B, Jiang Y, Guo Q, Das A, Jorge Sobrido A, Hing K, Zayats A and Krause S (2022). Photoelectrochemical Detection of Calcium Ions Based on Hematite Nanorod Sensors. American Chemical Society ACS Applied Nano Materials Meng Y, Chen F, Wu C, Krause S, Wang J and Zhang DW (2022). Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging Applications. American Chemical Society ACS Sensors 2021
Wan K, Liu Y, Santagiuliana G, Barandun G, Taroni Junior P, Güder F, Bastiaansen CWM, Baxendale M, Fenwick O, Papageorgiou DG, Krause S, Zhang H and Bilotti E (2021). Self-powered ultrasensitive and highly stretchable temperature–strain sensing composite yarns. Materials Horizons Zhou B, Das A, Zhong M, Guo Q, Zhang D-W, Hing KA, Sobrido AJ, Titirici M-M and Krause S (2021). Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responses. Elsevier Biosensors and Bioelectronics vol. 180, 2020
Tu Y, Kyle C, Luo H, Zhang DW, Das A, Briscoe J, Dunn S, Titirici MM and Krause S (2020). Ammonia Gas Sensor Response of a Vertical Zinc Oxide Nanorod-Gold Junction Diode at Room Temperature. ACS Sensors vol. 5, (11) 3568-3575. 2019
Zhou B, Das A, Kappers M, Oliver R, Humphreys C and Krause S (2019). InGaN as a substrate for AC photoelectrochemical imaging. MDPI Sensors Wang J, Yang Z, Chen W, Du L, Jiao B, Krause S, Wang P, Wei Q, Zhang D-W and Wu C (2019). Modulated light-activated electrochemistry at silicon functionalized with metal-organic frameworks towards addressable DNA chips. Elsevier Biosensors and Bioelectronics vol. 146, 111750-111750. Wan K, Taroni PJ, Liu Z, Liu Y, Tu Y, Santagiuliana G, Hsia I, Zhang H, Fenwick O, Krause S, Baxendale M, Schroeder BC and Bilotti E (2019). Flexible and Stretchable Self‐Powered Multi‐Sensors Based on the N‐Type Thermoelectric Response of Polyurethane/Na
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Composites. Wiley Advanced Electronic Materials 1900582-1900582. Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR and Krause S (2019). Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance. Biomacromolecules vol. 20, (7) 2506-2514. Wu F, Zhou B, Wang J, Zhong M, Das A, Watkinson M, Hing K, Zhang D-W and Krause S (2019). Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges. Anal Chem Ahmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR, Gautrot JE and Krause S (2019). Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of Collagenase. MDPI Sensors vol. 19, (7) 2018
Zhang D, Papaioannou N, Titirici M-M and Krause S (2018). Photoelectrochemical Imaging Using Carbon Dots (CDs) Derived from Chitosan. MDPI Proceedings vol. 2, (13) Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE and Krause S (2018). Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel Films. MDPI TU Y, AHMAD N, BRISCOE J, ZHANG D and KRAUSE S (2018). Light-Addressable Potentiometric Sensors using ZnO Nanorods as the Sensor Substrate for Bioanalytical Applications. American Chemical Society Analytical Chemistry Wang J, Du L, Krause S, Wu C and Wang P (2018). Surface modification and construction of LAPS towards biosensing applications. Sensors and Actuators, B: Chemical vol. 265, 161-173. ZHANG D, PAPAIOANNOU N, David NM, LUO H, GAO H, Tanase LC, Degousee T, Samori P, SAPELKIN A, FENWICK O, TITIRICI M and KRAUSE SK (2018). Photoelectrochemical response of carbon dots (CDs) derived from chitosan and their use in electrochemical imaging. Rsc Materials Horizons TU Y, CHEN S, LI X, GORBACIOVA J, GILLIN WP, KRAUSE S and BRISCOE J (2018). Control of oxygen vacancies in ZnO nanorods by annealing and their influence on ZnO/PEDOT:PSS diode behaviour. Royal Society of Chemistry Journal of Materials Chemistry C Schöning MJ, Wagner T, Poghossian A, Miyamoto K-I, Werner CF, Krause S and Yoshinobu T (2018). Light-Addressable Potentiometric Sensors for (Bio-)chemical Sensing and Imaging. Encyclopedia of Interfacial Chemistry Elsevier Yoshinobu T, Krause S, Miyamoto K-I, Werner CF, Poghossian A, Wagner T and Schöning MJ (2018). (Bio-)chemical Sensing and Imaging by LAPS and SPIM. Label-Free Biosensing Springer Nature 2017
Zhang D, Wu F and KRAUSE SK (2017). LAPS and SPIM imaging using ITO coated glass as the substrate material. American Chemical Society Analytical Chemistry Wu F, Campos I, Zhang D and KRAUSE SK (2017). Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopy. Royal Society, The Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences Zhang D and Krause S (2017). Image Detection of Yeast Saccharomyces Cerevisiae By Light-Addressable Potentiometric Sensors (LAPS). The Electrochemical Society ECS Meeting Abstracts vol. MA2017-01, (38) 1770-1770. Wu F, Watkinson M and Krause S (2017). Electrochemical Imaging of Copper Contamination on Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a ‘Click’ Reaction with Light-Addressable Potentiometric Sensors and Scanning Photo-Induced Impedance Microscopy. The Electrochemical Society ECS Meeting Abstracts vol. MA2017-01, (38) 1769-1769. Wu F, Zhang DW, Wang J, Watkinson M and Krause S (2017). Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click” Reaction Characterized with LAPS and SPIM. Langmuir vol. 33, (13) 3170-3177. 2016
Zhang DW, Wu F, Wang J, Watkinson M and KRAUSE SK (2016). Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS). Electrochemistry Communications vol. 72, 41-45. Wang J, Campos I, Wu F, Zhu J, Sukhorukov GB, Palma M, Watkinson M and Krause S (2016). The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopy. Electrochimica Acta vol. 208, 39-46. 2015
Wang J, Wu F, Watkinson M, Zhu J and Krause S (2015). click Patterning of Self-Assembled Monolayers on Hydrogen-Terminated Silicon Surfaces and Their Characterization Using Light-Addressable Potentiometric Sensors. Langmuir vol. 31, (35) 9646-9654. Gibbs MJ, Biela A and Krause S (2015). α-Amylase sensor based on the degradation of oligosaccharide hydrogel films monitored with a quartz crystal sensor. Biosens Bioelectron vol. 67, 540-545. Zhang H, Yilmaz P, Ansari JO, Khan FF, Binions R, Krause S and Dunn S (2015). Incorporation of Ag nanowires in CuWO4 for improved visible light-induced photoanode performance. Journal of Materials Chemistry A vol. 3, (18) 9638-9644. Biela A, Watkinson M, Meier UC, Baker D, Giovannoni G, Becer CR and Krause S (2015). Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopy. Biosensors and Bioelectronics vol. 68, 660-667. 2014
Wang J, Zhou Y, Watkinson M, Gautrot J and Krause S (2014). High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayers. Elsevier Sensors and Actuators B: Chemical vol. 209, 230-236. 2013
Dzaraini K, Norizan A, Krause S, Hunter C and Milanesi L (2013). Degradation behaviour of thin polymer films of poly (amide ester) hydrogel using quartz crystal microbalance. Advanced Materials Research vol. 812, 38-45. 2012
Zhang DW, Zhang FT, Cui YR, Deng QP, Krause S, Zhou YL and Zhang XX (2012). A label-free aptasensor for the sensitive and specific detection of cocaine using supramolecular aptamer fragments/target complex by electrochemical impedance spectroscopy. Talanta vol. 92, 65-71. 2011
Zheng X, Cook JP, Watkinson M, Yang S, Douglas I, Rawlinson A and Krause S (2011). Generic protease detection technology for monitoring periodontal disease. Faraday Discussions vol. 149, 37-47. 2010
Chen L, Zhou Y, Jiang S, Kunze J, Schmuki P and Krause S (2010). High resolution LAPS and SPIM. Electrochemistry Communications vol. 12, (6) 758-760. 2009
Kamarun D, Zheng XW, Milanesi L, Hunter CA and Krause S (2009). A peptide cross-linked polyacrylamide hydrogel for the detection of human neutrophil elastase. ELECTROCHIMICA ACTA vol. 54, (22) 4985-4990. Stair JL, Watkinson M and Krause S (2009). Sensor materials for the detection of proteases. Biosensors and Bioelectronics vol. 24, (7) 2113-2118. Sweeney SJ and Krause S (2009). Selected Papers from the Second International Conference on Optical, Optoelectronic and Photonic Materials and Applications, 2007. J MATER SCI-MATER EL vol. 20, 1-2. Sweeney SJ and Krause S (2009). Editorial: Selected papers from the second international conference on optical, optoelectronic and photonic materials and applications, 2007. Journal of Materials Science: Materials in Electronics vol. 20, (SUPPL. 1) 2008
Chen L, Zhou Y, Krause S, Munoz AG, Kunze J and Schmuki P (2008). Repair of thin thermally grown silicon dioxide by anodic oxidation. Electrochimica Acta vol. 53, (8) 3395-3402. 2007
Zhou Y, Jiang S, Krause S and Chazalviel J-N (2007). Biosensor arrays based on the degradation of thin polymer films interrogated by scanning photoinduced impedance microscopy. Anal Chem vol. 79, (23) 8974-8978. Zhou Y, Chen L, Krause S and Chazalviel J-N (2007). Scanning photoinduced impedance microscopy using amorphous silicon photodiode structures. Anal Chem vol. 79, (16) 6208-6214. 2006
Krause S, Moritz W, Talabani H, Xu M, Sabot A and Ensell G (2006). Scanning Photo-Induced Impedance Microscopy - Resolution studies and polymer characterization. ELECTROCHIMICA ACTA vol. 51, (8-9) 1423-1430. KRAUSE SK, Fernandez-Sanchez C and McNeil CJ (2006). Sensors based on thin film degradation. Encyclopedia of Sensors American Scientific Publishers 2004
Moritz W, Yoshinobu T, Finger F, Krause S, Martin-Fernandez M and Schoning MJ (2004). High resolution LAPS using amorphous silicon as the semiconductor material. SENSORS AND ACTUATORS B-CHEMICAL vol. 103, (1-2) 436-441. 2003
KRAUSE SK (2003). Impedance methods. Encyclopedia of Electrochemistry, Volume 3, Instrumentation and Electroanalytical Chemistry Wiley-VCH Verlag 2002
Sabot A and Krause S (2002). Simultaneous quartz crystal microbalance impedance and electrochemical impedance measurements. Investigation into the degradation of thin polymer films. Anal Chem vol. 74, (14) 3304-3311. Krause S, Talabani H, Xu M, Moritz W and Griffiths J (2002). Scanning photo-induced impedance microscopy - an impedance based imaging technique. ELECTROCHIMICA ACTA vol. 47, (13-14) 2143-2148. 2001
Sumner C, Krause S, Sabot A, Turner K and McNeil CJ (2001). Biosensor based on enzyme-catalysed degradation of thin polymer films. BIOSENSORS & BIOELECTRONICS vol. 16, (9-12) 709-714. Moritz W, Krause S, Roth U, Klimm D and Lippitz A (2001). Re-activation of an all solid state oxygen sensor. ANAL CHIM ACTA vol. 437, (2) 183-190. 2000
Sumner C, Sabot A, Turner K and Krause S (2000). A transducer based on enzyme-induced degradation of thin polymer films monitored by surface plasmon resonance. Anal Chem vol. 72, (21) 5225-5232. Moritz W, Gerhardt I, Roden D, Xu M and Krause S (2000). Photocurrent measurements for laterally resolved interface characterization. FRESENIUS JOURNAL OF ANALYTICAL CHEMISTRY vol. 367, (4) 329-333. 1999
Ho WO, Krause S, McNeil CJ, Pritchard JA, Armstrong RD, Athey D and Rawson K (1999). Electrochemical sensor for measurement of urea and creatinine in serum based on ac impedance measurement of enzyme-catalyzed polymer transformation. ANAL CHEM vol. 71, (10) 1940-1946. 1998
Moritz W, Krause S, Bartholomäus L, Gabusjan T, Vasiliev AA, Godovski DY and Malyshev VV (1998). Silicon-Based Sensor for Flourine Gas. ACS Symposium Series vol. 690, 119-129. 1995
McNeil CJ, Athey D, Ball M, Ho WO, Krause S, Armstrong RD, Des Wright J and Rawson K (1995). Electrochemical Sensors Based on Impedance Measurement of Enzyme-Catalyzed Polymer Dissolution: Theory and Applications. American Chemical Society (ACS) Analytical Chemistry vol. 67, (21) 3928-3935. Moritz W, Krause S, Vasiliev AA, Godovski DY and Malyshev VV (1995). Monitoring of HF and F2 using a field-effect sensor. Elsevier Sensors and Actuators B Chemical vol. 24, (1-3) 194-196. 1994
Krause S, Moritz W and Grohmann I (1994). Improved long-term stability for an LaF3 based oxygen sensor. Elsevier Sensors and Actuators B Chemical vol. 18, (1-3) 148-154. 1992
Krause S, Moritz W and Grohmann I (1992). A low-temperature oxygen sensor based on the Si/LaF3/Pt capacitive structure. Elsevier Sensors and Actuators B Chemical vol. 9, (3) 191-196. 1991
Bobrov PV, Tarantov YA, Krause S and Moritz W (1991). Chemical sensitivity of an ISFET with Ta2O5 membrane in strong acid and alkaline solutions. Elsevier Sensors and Actuators B Chemical vol. 3, (1) 75-81.