Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture
Kono Y, Pack C-G, Ichikawa T, Komatsubara A, Adam SA, Miyazawa K, Rolas L, Nourshargh S, Medalia O, Goldman RD, Fukuma T, Kimura H and Shimi T
Pnas Nexus, Oxford University Press (Oup) vol. 3 (12) 
21-11-2024

Protocol for volume correlative light X-ray and electron microscopy of endothelial cells in mouse tissue
Reglero-Real N, Pérez-Gutiérrez L, Saleeb RS, Nourshargh S, Collinson L and Yoshimura A
Star Protocols, Elsevier vol. 5 (3) 
01-09-2024

Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin M-B, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ and Nourshargh S
Embo Reports, Springer Nature vol. 25 (9), 3842-3869.  
25-06-2024

Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells
Benedicto I, Carmona RM, Barettino A, Espinós-Estévez C, Gonzalo P, Nevado RM, de la Fuente-Pérez M, Andrés-Manzano MJ, González-Gómez C, Rolas L, Dorado B, Nourshargh S, Hamczyk MR and Andrés V
Proceedings of The National Academy of Sciences, National Academy of Sciences 
22-04-2024

Regulation of ICAM-1 in human neutrophils
Vignarajah M, Wood AJT, Nelmes E, Subburayalu J, Herre J, Nourshargh S, Summers C, Chilvers ER and Farahi N
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 116 (4), 901-908.  
16-04-2024

ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Cacho-Navas C, López-Pujante C, Reglero-Real N, Colás-Algora N, Cuervo A, Conesa JJ, Barroso S, de Rivas G, Ciordia S, Paradela A, D'Agostino G, Manzo C, Feito J, Andrés G, Molina-Jiménez F, Majano P, Correas I, Carazo J-M, Nourshargh S, Huch M and Millán J
Elife, Elife vol. 12 
10-04-2024

Report from the 2023 workshop on endothelial permeability, edema and inflammation
Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J, Gamble J, Vadas M, Annex BH, Messe SR, Perretti M, André H, Ferrara N, Hla T, Nourshargh S and Simons M
Nature Cardiovascular Research, Springer Nature vol. 2 (12), 1120-1124.  
01-12-2023

Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A
Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J, Schnoor M, Voehringer D, Roers A, Nourshargh S and Voisin M-B
Nature Communications, Springer Nature vol. 13 (1) 
17-11-2022

Endothelial cell autophagy keeps neutrophil trafficking under control
Reglero-Real N, Pérez-Gutiérrez L and Nourshargh S
Autophagy, Taylor and Francis vol. 17 (12), 4509-4511.  
31-10-2021

Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome
Sánchez-López A, Espinós-Estévez C, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR, Macías Á, Del Campo L, Camafeita E, Vázquez J, Barkaway A, Rolas L, Nourshargh S, Dorado B, Benedicto I and Andrés V
Circulation vol. 144 (22), 1777-1794.  
25-10-2021

Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin M-B, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S
Immunity, Elsevier vol. 54 (9), 1989-2004.e9.  
06-08-2021

Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome
Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, Ortega-Nogales FJ, Balabasquer M, Gonzalo P, Khiar-Fernández N, Rolas L, Barkaway A, Nourshargh S, Andrés V, Martín-Fontecha M, López-Rodríguez ML and Ortega-Gutiérrez S
Acs Central Science, American Chemical Society (Acs) vol. 7 (8), 1300-1310.  
27-06-2021

Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice
Li W, Long L, Yang X, Tong Z, Southwood M, King R, Caruso P, Upton PD, Yang P, Bocobo GA, Nikolic I, Higuera A, Salmon RM, Jiang H, Lodge KM, Hoenderdos K, Baron RM, Yu PB, Condliffe AM, Summers C, Nourshargh S, Chilvers ER and Morrell NW
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society vol. 203 (11), 1419-1430.  
01-06-2021

Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin M-B, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T and Nourshargh S
Immunity, Elsevier vol. 54 (7), 1494-1510.e7.  
24-05-2021

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs
Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum FA, Arkill KP, Stein M, Girbl T, Golding M, Bates DO, Vestweber D, Voisin M and Nourshargh S
Journal of Clinical Investigation, American Society For Clinical Investigation 
23-01-2020

Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration
Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S, Cutillas P and Nightingale TD
Plos Biology, Public Library of Science (Plos) vol. 17 (12) 
02-12-2019

Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo
Arokiasamy S, King R, Boulaghrasse H, Poston R, Nourshargh S, Wang W and Voisin M-B
Frontiers in Immunology, Frontiers Media 
04-10-2019

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza A, Chang H-D, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B and Beisker W
European Journal of Immunology, Wiley vol. 49 (10), 1457-1973.  
01-10-2019

Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome
NOURSHARGH S, ROLAS L and BARKAWAY A
Nature Medicine, Nature Research, 423-426.  
18-02-2019

Neutrophil trafficking to lymphoid tissues: physiological and pathological implications
Voisin M and Nourshargh S
The Journal of Pathology, Wiley vol. 247 (5), 662-671.  
04-02-2019

Leukocyte Trafficking: Time to Take Time Seriously
Reglero-Real N, Rolas L and Nourshargh S
Immunity, Elsevier vol. 50 (2), 273-275.  
01-02-2019

Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury
VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C, PERRETTI M and NOURSHARGH S
Journal of Pathology, Wiley vol. 248 (1), 88-102.  
11-01-2019

Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis
GIRBL T, Lenn T, Perez L, ROLAS L, BARKAWAY A, Thiriot A, del Fresno C, Lynam E, HUB E, Thelen M, Graham G, Alon R, Sancho D, von Andrian UH, VOISIN M, ROT A and NOURSHARGH S
Immunity, Elsevier 
13-11-2018

Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S, Pennington DJ, Barnes MR and Brohi K
Plos Med vol. 15 (10), e1002694-e1002694.  
31-10-2018

Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Cossarizza A, Chang H-D, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A and Cosmi L
Eur J Immunol vol. 47 (10), 1584-1797.  
11-05-2018

Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis.
Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M, Zhang L, Ye S, Nourshargh S and Xiao Q
J Am Heart Assoc vol. 7 (4) 
08-02-2018

Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.
Schulz-Fincke A-C, Tikhomirov AS, Braune A, Girbl T, Gilberg E, Bajorath J, Blaut M, Nourshargh S and Gütschow M
Biochemistry vol. 57 (5), 742-752.  
06-02-2018

Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK.
Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN and Henson SM
Aging Cell, Wiley Open Access 
12-10-2017

Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma
CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB, O'DWYER M, NOURSHARGH S, PENNINGTON DJ, BARNES MR and BROHI K
Plos Medicine, Public Library of Science (Plos) 
17-07-2017

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S, Pennington DJ, Barnes MR and Brohi K
Plos Med vol. 14 (7) 
01-07-2017

Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation
Gittens BR, Bodkin JV, Nourshargh S, Perretti M and Cooper D
The Journal of Immunology, The American Association of Immunologists vol. 198 (11), 4458-4469.  
01-06-2017

Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation
VOISIN M
Scientific Reports, Nature Publishing Group 
13-03-2017

Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments
Barzilai S, Yadav SK, Morrell S, Roncato F, Klein E, Stoler-Barak L, Golani O, Feigelson SW, Zemel A, Nourshargh S and Alon R
Cell Reports, Elsevier vol. 18 (3), 685-699.  
01-01-2017

Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle.
Herrera C, Voisin M-B, Escalante T, Rucavado A, Nourshargh S and Gutiérrez JM
Plos One, Public Library of Science vol. 11 (12), e0168643-e0168643.  
16-12-2016

Endothelial Cell Junctional Adhesion Molecules
Reglero-Real N, Colom B, Bodkin JV and Nourshargh S
Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association, ATVBAHA.116-ATVBAHA.116.  
11-08-2016

Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment
WHITEFORD J, Ma B, Woodfin and Nourshargh
Journal of Pathology, Wiley 
01-08-2016

Reverse Migration of Neutrophils: Where, When, How, and Why?
Nourshargh S, Renshaw SA and Imhof BA
Trends in Immunology 
04-04-2016

ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia
Woodfin A, Beyrau M, Voisin M-B, Ma B, Whiteford JR, Hordijk PL, Hogg N and Nourshargh S
Blood, American Society of Hematology vol. 127 (7), 898-907.  
08-12-2015

Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states
Madalli S, Beyrau M, Whiteford J, Duchene J, Singh Nandhra I, Patel NSA, Motwani MP, Gilroy DW, Thiemermann C, Nourshargh S and Scotland RS
Biology of Sex Differences, Springer Nature vol. 6 (1) 
26-11-2015

Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction
Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S and Warner TD
Blood, The American Society of Hematology vol. 126 (10), e11-e18.  
27-07-2015

A Targeting Microbubble for Ultrasound Molecular Imaging
Yeh JS-M, Sennoga CA, McConnell E, Eckersley R, Tang M-X, Nourshargh S, Seddon JM, Haskard DO and Nihoyannopoulos P
Plos One, Public Library of Science (Plos) vol. 10 (7) 
10-07-2015

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo
Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K, Imhof BA and Nourshargh S
Immunity vol. 42 (6), 1075-1086.  
16-06-2015

Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo
Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K, Imhof BA and Nourshargh S
Immunity, Elsevier vol. 42 (6), 1075-1086.  
01-06-2015

Quantitative Ultrasound Molecular Imaging
Yeh JS-M, Sennoga CA, McConnell E, Eckersley R, Tang M-X, Nourshargh S, Seddon JM, Haskard DO and Nihoyannopoulos P
Ultrasound in Medicine & Biology, Elsevier vol. 41 (9), 2478-2496.  
01-06-2015

Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage
Herrera C, Escalante T, Voisin M-B, Rucavado A, Morazán D, Macêdo JKA, Calvete JJ, Sanz L, Nourshargh S, Gutiérrez JM and Fox JW
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 9 (4) 
24-04-2015

Shed syndecan-2 inhibits angiogenesis.
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S and Whiteford JR
J Cell Sci vol. 127 (Pt 21), 4788-4799.  
01-11-2014

Leukocyte Migration into Inflamed Tissues
Nourshargh S and Alon R
Immunity, Elsevier vol. 41 (5), 694-707.  
01-11-2014

Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.
Finsterbusch M, Voisin M-B, Beyrau M, Williams TJ and Nourshargh S
J Exp Med vol. 211 (7), 1307-1314.  
30-06-2014

ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.
Halai K, Whiteford J, Ma B, Nourshargh S and Woodfin A
J Cell Sci vol. 127 (Pt 3), 620-629.  
01-02-2014

Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T, Imhof BA, Balkwill FR and Nourshargh S
Faseb J vol. 27 (10), 4244-4253.  
01-10-2013

A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation.
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S and Perretti M
Blood vol. 122 (4), 608-617.  
25-07-2013

Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.
Alazawi W, Heath H, Waters JA, Woodfin A, O'Brien AJ, Scarzello AJ, Ma B, Lopez-Otalora Y, Jacobs M, Petts G, Goldin RD, Nourshargh S, Gamero AM and Foster GR
Proc Natl Acad Sci U S A vol. 110 (21), 8656-8661.  
21-05-2013

L2. Neutrophil transmigration in vivo: mechanisms, dynamics and contribution to dissemination of systemic inflammation.
Nourshargh S
Presse Med vol. 42 (4 Pt 2), 498-499.  
01-04-2013

Learning in motion: pericytes instruct migrating innate leukocytes.
Alon R and Nourshargh S
Nat Immunol vol. 14 (1), 14-15.  
01-01-2013

Neutrophil transmigration: emergence of an adhesive cascade within venular walls.
Voisin M-B and Nourshargh S
J Innate Immun vol. 5 (4), 336-347.  
01-01-2013

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.
Beyrau M, Bodkin JV and Nourshargh S
Open Biol vol. 2 (11) 
01-11-2012

CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.
Ma L, Cheung KCP, Kishore M, Nourshargh S, Mauro C and Marelli-Berg FM
J Immunol vol. 189 (8), 4104-4111.  
15-10-2012

The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.
Avari P, Huang W, Averill S, Colom B, Imhof BA, Nourshargh S and Priestley JV
Brain Behav vol. 2 (4), 402-414.  
01-07-2012

Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.
Proebstl D, Voisin M-B, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D and Nourshargh S
J Exp Med vol. 209 (6), 1219-1234.  
04-06-2012

The peritoneal tumour microenvironment of high-grade serous ovarian cancer.
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR
J Pathol vol. 227 (2), 136-145.  
01-06-2012

Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves.
Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML and Nourshargh S
Faseb J vol. 26 (3), 1064-1076.  
01-03-2012

Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31.
Kishore M, Ma L, Cornish G, Nourshargh S and Marelli-Berg FM
Plos One vol. 7 (6) 
01-01-2012

Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.
Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S and Couchman JR
Mol Biol Cell vol. 22 (19), 3609-3624.  
01-10-2011

The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.
Woodfin A, Voisin M-B, Beyrau M, Colom B, Caille D, Diapouli F-M, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA and Nourshargh S
Nat Immunol vol. 12 (8), 761-769.  
26-06-2011

CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism.
Veninga H, de Groot DM, McCloskey N, Owens BM, Dessing MC, Verbeek JS, Nourshargh S, van Eenennaam H, Boots AM and Hamann J
J Leukoc Biol vol. 89 (3), 413-421.  
01-03-2011

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.
Ma L, Mauro C, Cornish GH, Chai J-G, Coe D, Fu H, Patton D, Okkenhaug K, Franzoso G, Dyson J, Nourshargh S and Marelli-Berg FM
Proc Natl Acad Sci U S A vol. 107 (45), 19461-19466.  
09-11-2010

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.
Nourshargh S, Hordijk PL and Sixt M
Nat Rev Mol Cell Biol vol. 11 (5), 366-378.  
01-05-2010

The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature.
Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S and Perretti M
Br J Pharmacol vol. 160 (1), 171-180.  
01-05-2010

Recent developments and complexities in neutrophil transmigration.
Woodfin A, Voisin M-B and Nourshargh S
Curr Opin Hematol vol. 17 (1), 9-17.  
01-01-2010

Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.
Voisin M-B, Pröbstl D and Nourshargh S
Am J Pathol vol. 176 (1), 482-495.  
01-01-2010

Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.
Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C, Thiemermann C, Aurrand-Lions M, Imhof BA and Nourshargh S
Arterioscler Thromb Vasc Biol vol. 29 (10), 1509-1515.  
01-10-2009

Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo.
Voisin M-B, Woodfin A and Nourshargh S
Arterioscler Thromb Vasc Biol vol. 29 (8), 1193-1199.  
01-08-2009

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.
Woodfin A, Voisin M-B, Imhof BA, Dejana E, Engelhardt B and Nourshargh S
Blood vol. 113 (24), 6246-6257.  
11-06-2009

Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1
Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B and Nourshargh S
Blood vol. 113 (24), 6246-6257.  
11-06-2009

Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.
Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, Nourshargh S, Cook HT and Pusey CD
Am J Pathol vol. 174 (4), 1212-1220.  
01-04-2009

PECAM-1: a multi-functional molecule in inflammation and vascular biology.
Woodfin A, Voisin M-B and Nourshargh S
Arterioscler Thromb Vasc Biol vol. 27 (12), 2514-2523.  
01-12-2007

Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves.
Scheiermann C, Meda P, Aurrand-Lions M, Madani R, Yiangou Y, Coffey P, Salt TE, Ducrest-Gay D, Caille D, Howell O, Reynolds R, Lobrinus A, Adams RH, Yu ASL, Anand P, Imhof BA and Nourshargh S
Science vol. 318 (5855), 1472-1475.  
30-11-2007

JAM family and related proteins in leukocyte migration (Vestweber series).
Bradfield PF, Nourshargh S, Aurrand-Lions M and Imhof BA
Arterioscler Thromb Vasc Biol vol. 27 (10), 2104-2112.  
01-10-2007

JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.
Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M and Imhof BA
Blood vol. 110 (7), 2545-2555.  
01-10-2007

JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.
Woodfin A, Reichel CA, Khandoga A, Corada M, Voisin M-B, Scheiermann C, Haskard DO, Dejana E, Krombach F and Nourshargh S
Blood vol. 110 (6), 1848-1856.  
15-09-2007

Getting to the site of inflammation: the leukocyte adhesion cascade updated.
Ley K, Laudanna C, Cybulsky MI and Nourshargh S
Nat Rev Immunol vol. 7 (9), 678-689.  
01-09-2007

JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: Evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration
NOURSHARGH S, Krombach F, Dejana E, Khandoga A, Woodfin A, Reichal AC, Haskard DO, Scheiermann C, Voisin MB and Corada M
Blood vol. 110 (6), 1848-1856.  
01-09-2007

Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.
Young RE, Voisin M-B, Wang S, Dangerfield J and Nourshargh S
Br J Pharmacol vol. 151 (5), 628-637.  
01-07-2007

Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1.
Potter PK, Larbi KY, Nourshargh S and Botto M
Mol Immunol vol. 44 (6), 1135-1140.  
01-02-2007

Role of α6β1 integrin in leukocyte adhesion and transmigration
Voisin M-B and Nourshargh S
In Adhesion Molecules: Function and Inhibition, Springer Nature 221-235.  
01-01-2007

The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues.
Nourshargh S, Krombach F and Dejana E
J Leukoc Biol vol. 80 (4), 714-718.  
01-10-2006

Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils
Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L and Nourshargh S
Journal of Cell Biology, Rockefeller University Press vol. 173 (6), i11-i11.  
19-06-2006

ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration.
Huang M-T, Larbi KY, Scheiermann C, Woodfin A, Gerwin N, Haskard DO and Nourshargh S
Blood vol. 107 (12), 4721-4727.  
15-06-2006

Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils.
Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L and Nourshargh S
J Exp Med vol. 203 (6), 1519-1532.  
12-06-2006

Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo.
Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu S-Y, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG and Poznansky MC
J Leukoc Biol vol. 79 (3), 539-554.  
01-03-2006

Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy.
Ambrose LR, Little MA, Nourshargh S and Pusey CD
Kidney Int vol. 68 (6), 2912-2913.  
01-12-2005

Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo.
Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S and Pusey CD
Blood vol. 106 (6), 2050-2058.  
15-09-2005

Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro.
Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ and Perretti M
J Leukoc Biol vol. 78 (3), 639-646.  
01-09-2005

Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules
Marelli‐Berg FM and Nourshargh S
In Leukocyte Trafficking, Wiley 82-108.  
23-08-2005

Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation.
Aurrand-Lions M, Lamagna C, Dangerfield JP, Wang S, Herrera P, Nourshargh S and Imhof BA
J Immunol vol. 174 (10), 6406-6415.  
15-05-2005

PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration.
Wang S, Dangerfield JP, Young RE and Nourshargh S
J Cell Sci vol. 118 (Pt 9), 2067-2076.  
01-05-2005

Transmigration through venular walls: a key regulator of leukocyte phenotype and function.
Nourshargh S and Marelli-Berg FM
Trends Immunol vol. 26 (3), 157-165.  
01-03-2005

Blockade of alpha6 integrin inhibits IL-1beta- but not TNF-alpha-induced neutrophil transmigration in vivo.
Dangerfield JP, Wang S and Nourshargh S
J Leukoc Biol vol. 77 (2), 159-165.  
01-02-2005

Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo.
Marelli-Berg FM, James MJ, Dangerfield J, Dyson J, Millrain M, Scott D, Simpson E, Nourshargh S and Lechler RI
Blood vol. 103 (8), 3111-3116.  
15-04-2004

Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo
Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M and Nourshargh S
J Immunol vol. 172 (7), 4493-4502.  
01-04-2004

Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ and Botto M
J Immunol vol. 172 (6), 3406-3414.  
15-03-2004

Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation.
McMillan SJ, Kearley J, Campbell JD, Zhu X-W, Larbi KY, Shipley JM, Senior RM, Nourshargh S and Lloyd CM
J Immunol vol. 172 (4), 2586-2594.  
15-02-2004

Migration of leukocytes through the vessel wall and beyond
Yadav R, Larbi KY, Young RE and Nourshargh S
Thrombosis and Haemostasis vol. 90 (4), 598-606.  
01-10-2003

Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism.
James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D, Simpson E, Cardozo L, Warrens A, Szydlo RM, Lechler RI and Marelli-Berg FM
Blood vol. 102 (6), 2173-2179.  
15-09-2003

MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha.
Marshall D, Dangerfield JP, Bhatia VK, Larbi KY, Nourshargh S and Haskard DO
Rheumatology (Oxford) vol. 42 (8), 929-934.  
01-08-2003

P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.
Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ and Nourshargh S
J Leukoc Biol vol. 73 (1), 65-73.  
01-01-2003

Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules.
Young RE, Thompson RD and Nourshargh S
Br J Pharmacol vol. 137 (8), 1237-1246.  
01-12-2002

PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane.
Dangerfield J, Larbi KY, Huang M-T, Dewar A and Nourshargh S
J Exp Med vol. 196 (9), 1201-1211.  
04-11-2002

MRL/lpr LUPUS-PRONE MICE SHOW EXAGGERATED ICAM-1 DEPENDENT LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN RESPONSE TO TNF alpha
Marshall D, Dangerfield JD, Bhatia VK, Larbi KY, Nourshargh S and Haskard DO
Rheumatology vol. 41, 32-32.  
01-04-2002

Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta (IL-1 beta) and factor-alpha (TNF alpha) in mouse cremasteric venules.
Young RE, Thompson RD and Nourshargh S
Brit J Pharmacol vol. 135 
01-03-2002

Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane.
Thompson RD, Noble KE, Larbi KY, Dewar A, Duncan GS, Mak TW and Nourshargh S
Blood vol. 97 (6), 1854-1860.  
15-03-2001

Expression of P- but not E-selectin in peritoneal microvasculature during inflammatory peritonitis
Marshall D, Bhatia VK, Ahmed S, Lidington EA, Larbi KY, Nourshargh S and Haskard DO
Faseb J vol. 15 (4), A328-A328.  
07-03-2001

VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration.
Larbi KY, Allen AR, Tam FWK, Haskard DO, Lobb RR, Silva PMR and Nourshargh S
Blood, American Society of Hematology vol. 96 (10), 3601-3609.  
15-11-2000

An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation
Asimakopoulos G, Thompson R, Nourshargh S, Lidington EA, Mason JC, Ratnatunga CP, Haskard DO, Taylor KM and Landis RC
Journal of Thoracic and Cardiovascular Surgery, Elsevier vol. 120 (2), 361-369.  
01-08-2000

Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and β3 Integrin Blockade on Leukocyte Transmigration In Vivo
Thompson RD, Wakelin MW, Larbi KY, Dewar A, Asimakopoulos G, Horton MA, Nakada MT and Nourshargh S
The Journal of Immunology, The American Association of Immunologists vol. 165 (1), 426-434.  
01-07-2000

VCAM‐1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM‐1 in rat skin
DAVIES¶ , LARBI , ALLEN , SANZ , WEG , HASKARD , LOBB and NOURSHARGH
Immunology, Wiley vol. 97 (1), 150-158.  
01-05-1999

Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of α4 integrins and vascular cell adhesion molecule‐1
NAGAI , LARKIN§ , HARTNELL , LARBI , AGHAKHANI R, WINDLEY , DAVIES , LOBB , WILLIAMS and NOURSHARGH
Immunology, Wiley vol. 96 (2), 176-183.  
01-02-1999

IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.
Sanz M-J, Marinova-Mutafchieva L, Green P, Lobb RR, Feldmann M and Nourshargh S
The Journal of Immunology, The American Association of Immunologists vol. 160 (11), 5637-5645.  
01-06-1998

Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4.
Sanz M-J, Ponath PD, Mackay CR, Newman W, Miyasaka M, Tamatani T, Flanagan BF, Lobb RR, Williams TJ, Nourshargh S and Jose PJ
The Journal of Immunology, The American Association of Immunologists vol. 160 (7), 3569-3576.  
01-04-1998

TNFα and IFNγ act synergistically to induce leukocyte rolling and adhesion but not extravasation in vivo
Wakelin MW and Nourshargh S
Faseb Journal vol. 11 (3) 
01-12-1997

Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways
Sanz M-J, Hartnell A, Chisholm P, Williams C, Davies D, Weg VB, Feldmann M, Bolanowski MA, Lobb RR and Nourshargh S
Blood, American Society of Hematology vol. 90 (10), 4144-4152.  
15-11-1997

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.
Wakelin MW, Sanz MJ, Dewar A, Albelda SM, Larkin SW, Boughton-Smith N, Williams TJ and Nourshargh S
Journal of Experimental Medicine, Rockefeller University Press vol. 184 (1), 229-239.  
01-07-1996

Molecular and cellular interactions mediating granulocyteaccumulation in vivo
Nourshargh S and Williams TJ
Seminars in Cell and Developmental Biology, Elsevier vol. 6 (6), 317-326.  
01-12-1995

Interleukin-1-Induced Leukocyte Extravasation Across Rat Mesenteric Microvessels Is Mediated by Platelet-Activating Factor
Nourshargh S, Larkin SW, Das A and Williams TJ
Blood, American Society of Hematology vol. 85 (9), 2553-2558.  
01-05-1995

Substance P‐induced inflammatory responses in guinea‐pig skin: The effect of specific NK1 receptor antagonists and the role of endogenous mediators
Walsh DT, Weg VB, Williams TJ and Nourshargh S
British Journal of Pharmacology, Wiley vol. 114 (7), 1343-1350.  
01-04-1995

IL-1 is a potent inducer of eosinophil accumulation in rat skin. Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody.
Sanz MJ, Weg VB, Bolanowski MA and Nourshargh S
The Journal of Immunology, The American Association of Immunologists vol. 154 (3), 1364-1373.  
01-02-1995

LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.
Weg VB, Walsh DT, Faccioli LH, Williams TJ, Feldmann M and Nourshargh S
Immunology vol. 84 (1), 36-40.  
01-01-1995

Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model.
Das AM, Williams TJ, Lobb R and Nourshargh S
Immunology vol. 84 (1), 41-46.  
01-01-1995

Differential effects of the PAF receptor antagonist UK‐74,505 on neutrophil and eosinophil accumulation in guinea‐pig skin
Sanz MJ, Weg VB, Walsh DT, Williams TJ and Nourshargh S
British Journal of Pharmacology, Wiley vol. 113 (2), 513-521.  
01-10-1994

Role of platelet‐activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long‐acting PAF antagonist, UK‐74,505
Pons F, Rossi AG, Norman KE, Williams TJ and Nourshargh S
British Journal of Pharmacology, Wiley vol. 109 (1), 234-242.  
01-05-1993

Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action
Yarwood H, Nourshargh S, Brain S and Williams TJ
British Journal of Pharmacology, Wiley vol. 108 (4), 959-966.  
01-04-1993

A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo.
Weg VB, Williams TJ, Lobb RR and Nourshargh S
Journal of Experimental Medicine, Rockefeller University Press vol. 177 (2), 561-566.  
01-02-1993

Comparative responses of human and rabbit interleukin-1 in vivo: effect of a recombinant interleukin-1 receptor antagonist.
von Uexküll C, Nourshargh S and Williams TJ
Immunology vol. 77 (4), 483-487.  
01-12-1992

A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8.
Nourshargh S, Perkins JA, Showell HJ, Matsushima K, Williams TJ and Collins PD
The Journal of Immunology, The American Association of Immunologists vol. 148 (1), 106-111.  
01-01-1992

Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung
Seale JP, Nourshargh S, Hellewell PG and Williams TJ
British Journal of Pharmacology, Wiley vol. 104 (1), 251-257.  
01-09-1991

Neutrophils in Asthmaa
WILLIAMS TJ, DAS A, von UEXKULL C and NOURSHARGH S
Annals of The New York Academy of Sciences, Wiley vol. 629 (1), 73-81.  
01-07-1991

The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo.
Faccioli LH, Nourshargh S, Moqbel R, Williams FM, Sehmi R, Kay AB and Williams TJ
Immunology vol. 73 (2), 222-227.  
01-06-1991

Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo.
Nourshargh S and Williams TJ
The Journal of Immunology, The American Association of Immunologists vol. 145 (8), 2633-2638.  
15-10-1990

Accumulation of 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen.
Nourshargh S, Rampart M, Hellewell PG, Jose PJ, Harlan JM, Edwards AJ and Williams TJ
The Journal of Immunology, The American Association of Immunologists vol. 142 (9), 3193-3198.  
01-05-1989

Alteration in microvascular permeability induced by products released during inflammation.
Williams TJ, Brain SD, Hellewell PG, Jose PJ, Nourshargh S and Rampart M
Progress in Clinical and Biological Research vol. 263, 55-69.  
01-01-1988

Divergent effects of co‐carcinogenic phorbol esters and a synthetic diacylglycerol on human neutrophil chemokinesis and granular enzyme secretion
Nourshargh S and Hoult JRS
British Journal of Pharmacology, Wiley vol. 91 (3), 557-568.  
01-07-1987

Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors
Nourshargh S and Hoult JRS
European Journal of Pharmacology, Elsevier vol. 122 (2), 205-212.  
01-03-1986

Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis
Hoult JRS and Nourshargh S
British Journal of Pharmacology, Wiley vol. 86 (3), 533-537.  
01-11-1985