Reglero-Real N, Pérez-Gutiérrez L, Saleeb RS, Nourshargh S, Collinson L and Yoshimura A (2024). Protocol for volume correlative light X-ray and electron microscopy of endothelial cells in mouse tissue. Elsevier  STAR Protocols  vol. 5, (3)  

Rolas L, Stein M, Barkaway A, Reglero-Real N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L, Golding M, Blacksell IA, Giblin MJ, Jaworska E, Bishop CL, Voisin M-B, Gaston-Massuet C, Fossati-Jimack L, Pitzalis C, Cooper D, Nightingale TD, Lopez-Otin C, Lewis MJ and Nourshargh S (2024). Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues. Springer Nature  EMBO Reports  vol. 25, (9) 3842-3869.  

Benedicto I, Carmona RM, Barettino A, Espinós-Estévez C, Gonzalo P, Nevado RM, de la Fuente-Pérez M, Andrés-Manzano MJ, González-Gómez C, Rolas L, Dorado B, Nourshargh S, Hamczyk MR and Andrés V (2024). Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells. National Academy of Sciences  Proceedings of the National Academy of Sciences   

Vignarajah M, Wood AJT, Nelmes E, Subburayalu J, Herre J, Nourshargh S, Summers C, Chilvers ER and Farahi N (2024). Regulation of ICAM-1 in human neutrophils. Oxford University Press (OUP)  Journal of Leukocyte Biology  vol. 116, (4) 901-908.  

Cacho-Navas C, López-Pujante C, Reglero-Real N, Colás-Algora N, Cuervo A, Conesa JJ, Barroso S, de Rivas G, Ciordia S, Paradela A, D'Agostino G, Manzo C, Feito J, Andrés G, Molina-Jiménez F, Majano P, Correas I, Carazo J-M, Nourshargh S, Huch M and Millán J (2024). ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin. eLife  eLife  vol. 12,  

Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J, Gamble J, Vadas M, Annex BH, Messe SR, Perretti M, André H, Ferrara N, Hla T, Nourshargh S and Simons M (2023). Report from the 2023 workshop on endothelial permeability, edema and inflammation. Springer Nature  Nature Cardiovascular Research  vol. 2, (12) 1120-1124.  

Joulia R, Guerrero-Fonseca IM, Girbl T, Coates JA, Stein M, Vázquez-Martínez L, Lynam E, Whiteford J, Schnoor M, Voehringer D, Roers A, Nourshargh S and Voisin M-B (2022). Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A. Springer Nature  Nature Communications  vol. 13, (1)  

Reglero-Real N, Pérez-Gutiérrez L and Nourshargh S (2021). Endothelial cell autophagy keeps neutrophil trafficking under control. Taylor and Francis  Autophagy  vol. 17, (12) 4509-4511.  

Sánchez-López A, Espinós-Estévez C, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR, Macías Á, Del Campo L, Camafeita E, Vázquez J, Barkaway A, Rolas L, Nourshargh S, Dorado B, Benedicto I and Andrés V (2021). Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome. Circulation  vol. 144, (22) 1777-1794.  

Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin M-B, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Elsevier  Immunity  vol. 54, (9) 1989-2004.e9.  

Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, Ortega-Nogales FJ, Balabasquer M, Gonzalo P, Khiar-Fernández N, Rolas L, Barkaway A, Nourshargh S, Andrés V, Martín-Fontecha M, López-Rodríguez ML and Ortega-Gutiérrez S (2021). Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome. American Chemical Society (ACS)  ACS Central Science  vol. 7, (8) 1300-1310.  

Li W, Long L, Yang X, Tong Z, Southwood M, King R, Caruso P, Upton PD, Yang P, Bocobo GA, Nikolic I, Higuera A, Salmon RM, Jiang H, Lodge KM, Hoenderdos K, Baron RM, Yu PB, Condliffe AM, Summers C, Nourshargh S, Chilvers ER and Morrell NW (2021). Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice. American Thoracic Society  American Journal of Respiratory and Critical Care Medicine  vol. 203, (11) 1419-1430.  

Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M, Vázquez-Martínez L, Girbl T, Poston RN, Golding M, Saleeb RS, Thiriot A, von Andrian UH, Duchene J, Voisin M-B, Bishop CL, Voehringer D, Roers A, Rot A, Lämmermann T and Nourshargh S (2021). Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage. Elsevier  Immunity  vol. 54, (7) 1494-1510.e7.  

Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum FA, Arkill KP, Stein M, Girbl T, Golding M, Bates DO, Vestweber D, Voisin M and Nourshargh S (2020). Local microvascular leakage promotes trafficking of activated neutrophils to remote organs. American Society for Clinical Investigation  Journal of Clinical Investigation   

Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S, Cutillas P and Nightingale TD (2019). Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration. Public Library of Science (PLoS)  PLOS Biology  vol. 17, (12)  

Arokiasamy S, King R, Boulaghrasse H, Poston R, Nourshargh S, Wang W and Voisin M-B (2019). Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo. Frontiers Media  Frontiers in Immunology   

Cossarizza A, Chang H-D, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N, Akdis M, Allez M, Almeida LN, Alvisi G, Anderson G, Andrä I, Annunziato F, Anselmo A, Bacher P, Baldari CT, Bari S, Barnaba V, Barros-Martins J, Battistini L, Bauer W, Baumgart S, Baumgarth N, Baumjohann D, Baying B, Bebawy M, Becher B and Beisker W (2019). Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition). Wiley  European Journal of Immunology  vol. 49, (10) 1457-1973.  

NOURSHARGH S, ROLAS L and BARKAWAY A (2019). Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome. Nature Research  Nature Medicine  423-426.  

Voisin M and Nourshargh S (2019). Neutrophil trafficking to lymphoid tissues: physiological and pathological implications. Wiley  The Journal of Pathology  vol. 247, (5) 662-671.  

Reglero-Real N, Rolas L and Nourshargh S (2019). Leukocyte Trafficking: Time to Take Time Seriously. Elsevier  Immunity  vol. 50, (2) 273-275.  

VOISIN M, leoni G, WOODFIN A, loumagne L, PATEL N, Di Paola R, Cuzzocrea S, THIEMERMANN C, PERRETTI M and NOURSHARGH S (2019). Neutrophil elastase plays a non-redundant role in remodeling the venular basement membrane and neutrophil diapedesis post ischemia/reperfusion injury. Wiley  Journal of Pathology  vol. 248, (1) 88-102.  

GIRBL T, Lenn T, Perez L, ROLAS L, BARKAWAY A, Thiriot A, del Fresno C, Lynam E, HUB E, Thelen M, Graham G, Alon R, Sancho D, von Andrian UH, VOISIN M, ROT A and NOURSHARGH S (2018). Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis. Elsevier  Immunity   

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S, Pennington DJ, Barnes MR and Brohi K (2018). Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. PLoS Med  vol. 15, (10) e1002694-e1002694.  

Cossarizza A, Chang H-D, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A and Cosmi L (2018). Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol  vol. 47, (10) 1584-1797.  

Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M, Zhang L, Ye S, Nourshargh S and Xiao Q (2018). Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis. J Am Heart Assoc  vol. 7, (4)  

Schulz-Fincke A-C, Tikhomirov AS, Braune A, Girbl T, Gilberg E, Bajorath J, Blaut M, Nourshargh S and Gütschow M (2018). Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers. Biochemistry  vol. 57, (5) 742-752.  

Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN and Henson SM (2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK. Wiley Open Access  Aging Cell   

CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB, O'DWYER M, NOURSHARGH S, PENNINGTON DJ, BARNES MR and BROHI K (2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. Public Library of Science (PLoS)  PLoS Medicine   

Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O'Dwyer M, Nourshargh S, Pennington DJ, Barnes MR and Brohi K (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. PLoS Med  vol. 14, (7)  

Gittens BR, Bodkin JV, Nourshargh S, Perretti M and Cooper D (2017). Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation. The American Association of Immunologists  The Journal of Immunology  vol. 198, (11) 4458-4469.  

VOISIN M (2017). Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation. Nature Publishing Group  Scientific Reports   

Barzilai S, Yadav SK, Morrell S, Roncato F, Klein E, Stoler-Barak L, Golani O, Feigelson SW, Zemel A, Nourshargh S and Alon R (2017). Leukocytes Breach Endothelial Barriers by Insertion of Nuclear Lobes and Disassembly of Endothelial Actin Filaments. Elsevier  Cell Reports  vol. 18, (3) 685-699.  

Herrera C, Voisin M-B, Escalante T, Rucavado A, Nourshargh S and Gutiérrez JM (2016). Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle. Public Library of Science  PLoS One  vol. 11, (12) e0168643-e0168643.  

Reglero-Real N, Colom B, Bodkin JV and Nourshargh S (2016). Endothelial Cell Junctional Adhesion Molecules. American Heart Association  Arteriosclerosis, Thrombosis and Vascular Biology  ATVBAHA.116-ATVBAHA.116.  

WHITEFORD J, Ma B, Woodfin and Nourshargh (2016). Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment. Wiley  Journal of Pathology   

Nourshargh S, Renshaw SA and Imhof BA (2016). Reverse Migration of Neutrophils: Where, When, How, and Why? Trends in immunology   

Woodfin A, Beyrau M, Voisin M-B, Ma B, Whiteford JR, Hordijk PL, Hogg N and Nourshargh S (2015). ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia. American Society of Hematology  Blood  vol. 127, (7) 898-907.  

Madalli S, Beyrau M, Whiteford J, Duchene J, Singh Nandhra I, Patel NSA, Motwani MP, Gilroy DW, Thiemermann C, Nourshargh S and Scotland RS (2015). Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states. Springer Nature  Biology of Sex Differences  vol. 6, (1)  

Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S and Warner TD (2015). Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction. The American Society of Hematology  Blood  vol. 126, (10) e11-e18.  

Yeh JS-M, Sennoga CA, McConnell E, Eckersley R, Tang M-X, Nourshargh S, Seddon JM, Haskard DO and Nihoyannopoulos P (2015). A Targeting Microbubble for Ultrasound Molecular Imaging. Public Library of Science (PLoS)  PLOS ONE  vol. 10, (7)  

Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K, Imhof BA and Nourshargh S (2015). Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo. Immunity  vol. 42, (6) 1075-1086.  

Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K, Imhof BA and Nourshargh S (2015). Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. Elsevier  Immunity  vol. 42, (6) 1075-1086.  

Yeh JS-M, Sennoga CA, McConnell E, Eckersley R, Tang M-X, Nourshargh S, Seddon JM, Haskard DO and Nihoyannopoulos P (2015). Quantitative Ultrasound Molecular Imaging. Elsevier  Ultrasound in Medicine & Biology  vol. 41, (9) 2478-2496.  

Herrera C, Escalante T, Voisin M-B, Rucavado A, Morazán D, Macêdo JKA, Calvete JJ, Sanz L, Nourshargh S, Gutiérrez JM and Fox JW (2015). Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage. Public Library of Science (PLoS)  PLOS Neglected Tropical Diseases  vol. 9, (4)  

De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S and Whiteford JR (2014). Shed syndecan-2 inhibits angiogenesis. J Cell Sci  vol. 127, (Pt 21) 4788-4799.  

Nourshargh S and Alon R (2014). Leukocyte Migration into Inflamed Tissues. Elsevier  Immunity  vol. 41, (5) 694-707.  

Finsterbusch M, Voisin M-B, Beyrau M, Williams TJ and Nourshargh S (2014). Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF. J Exp Med  vol. 211, (7) 1307-1314.  

Halai K, Whiteford J, Ma B, Nourshargh S and Woodfin A (2014). ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo. J Cell Sci  vol. 127, (Pt 3) 620-629.  

Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T, Imhof BA, Balkwill FR and Nourshargh S (2013). Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer. FASEB J  vol. 27, (10) 4244-4253.  

Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S and Perretti M (2013). A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation. Blood  vol. 122, (4) 608-617.  

Alazawi W, Heath H, Waters JA, Woodfin A, O'Brien AJ, Scarzello AJ, Ma B, Lopez-Otalora Y, Jacobs M, Petts G, Goldin RD, Nourshargh S, Gamero AM and Foster GR (2013). Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis. Proc Natl Acad Sci U S A  vol. 110, (21) 8656-8661.  

Nourshargh S (2013). L2. Neutrophil transmigration in vivo: mechanisms, dynamics and contribution to dissemination of systemic inflammation. Presse Med  vol. 42, (4 Pt 2) 498-499.  

Alon R and Nourshargh S (2013). Learning in motion: pericytes instruct migrating innate leukocytes. Nat Immunol  vol. 14, (1) 14-15.  

Voisin M-B and Nourshargh S (2013). Neutrophil transmigration: emergence of an adhesive cascade within venular walls. J Innate Immun  vol. 5, (4) 336-347.  

Beyrau M, Bodkin JV and Nourshargh S (2012). Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity. Open Biol  vol. 2, (11)  

Ma L, Cheung KCP, Kishore M, Nourshargh S, Mauro C and Marelli-Berg FM (2012). CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo. J Immunol  vol. 189, (8) 4104-4111.  

Avari P, Huang W, Averill S, Colom B, Imhof BA, Nourshargh S and Priestley JV (2012). The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats. Brain Behav  vol. 2, (4) 402-414.  

Proebstl D, Voisin M-B, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D and Nourshargh S (2012). Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo. J Exp Med  vol. 209, (6) 1219-1234.  

Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D, Ennis DP, Lockley M, McNeish IA, Nourshargh S and Balkwill FR (2012). The peritoneal tumour microenvironment of high-grade serous ovarian cancer. J Pathol  vol. 227, (2) 136-145.  

Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Del Carro U, Zambroni D, Brain SD, Perretti M, Ahluwalia A, Priestley JV, Chavakis T, Imhof BA, Feltri ML and Nourshargh S (2012). Schwann cell-specific JAM-C-deficient mice reveal novel expression and functions for JAM-C in peripheral nerves. FASEB J  vol. 26, (3) 1064-1076.  

Kishore M, Ma L, Cornish G, Nourshargh S and Marelli-Berg FM (2012). Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31. PLoS One  vol. 7, (6)  

Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S and Couchman JR (2011). Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148. Mol Biol Cell  vol. 22, (19) 3609-3624.  

Woodfin A, Voisin M-B, Beyrau M, Colom B, Caille D, Diapouli F-M, Nash GB, Chavakis T, Albelda SM, Rainger GE, Meda P, Imhof BA and Nourshargh S (2011). The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo. Nat Immunol  vol. 12, (8) 761-769.  

Veninga H, de Groot DM, McCloskey N, Owens BM, Dessing MC, Verbeek JS, Nourshargh S, van Eenennaam H, Boots AM and Hamann J (2011). CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism. J Leukoc Biol  vol. 89, (3) 413-421.  

Ma L, Mauro C, Cornish GH, Chai J-G, Coe D, Fu H, Patton D, Okkenhaug K, Franzoso G, Dyson J, Nourshargh S and Marelli-Berg FM (2010). Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance. Proc Natl Acad Sci U S A  vol. 107, (45) 19461-19466.  

Nourshargh S, Hordijk PL and Sixt M (2010). Breaching multiple barriers: leukocyte motility through venular walls and the interstitium. Nat Rev Mol Cell Biol  vol. 11, (5) 366-378.  

Leoni G, Voisin M-B, Carlson K, Getting S, Nourshargh S and Perretti M (2010). The melanocortin MC(1) receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature. Br J Pharmacol  vol. 160, (1) 171-180.  

Woodfin A, Voisin M-B and Nourshargh S (2010). Recent developments and complexities in neutrophil transmigration. Curr Opin Hematol  vol. 17, (1) 9-17.  

Voisin M-B, Pröbstl D and Nourshargh S (2010). Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation. Am J Pathol  vol. 176, (1) 482-495.  

Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C, Thiemermann C, Aurrand-Lions M, Imhof BA and Nourshargh S (2009). Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury. Arterioscler Thromb Vasc Biol  vol. 29, (10) 1509-1515.  

Voisin M-B, Woodfin A and Nourshargh S (2009). Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo. Arterioscler Thromb Vasc Biol  vol. 29, (8) 1193-1199.  

Woodfin A, Voisin M-B, Imhof BA, Dejana E, Engelhardt B and Nourshargh S (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. Blood  vol. 113, (24) 6246-6257.  

Woodfin A, Voisin MB, Imhof BA, Dejana E, Engelhardt B and Nourshargh S (2009). Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1. BLOOD  vol. 113, (24) 6246-6257.  

Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, Nourshargh S, Cook HT and Pusey CD (2009). Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis. Am J Pathol  vol. 174, (4) 1212-1220.  

Woodfin A, Voisin M-B and Nourshargh S (2007). PECAM-1: a multi-functional molecule in inflammation and vascular biology. Arterioscler Thromb Vasc Biol  vol. 27, (12) 2514-2523.  

Scheiermann C, Meda P, Aurrand-Lions M, Madani R, Yiangou Y, Coffey P, Salt TE, Ducrest-Gay D, Caille D, Howell O, Reynolds R, Lobrinus A, Adams RH, Yu ASL, Anand P, Imhof BA and Nourshargh S (2007). Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves. Science  vol. 318, (5855) 1472-1475.  

Bradfield PF, Nourshargh S, Aurrand-Lions M and Imhof BA (2007). JAM family and related proteins in leukocyte migration (Vestweber series). Arterioscler Thromb Vasc Biol  vol. 27, (10) 2104-2112.  

Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M, Aurrand-Lions M and Imhof BA (2007). JAM-C regulates unidirectional monocyte transendothelial migration in inflammation. Blood  vol. 110, (7) 2545-2555.  

Woodfin A, Reichel CA, Khandoga A, Corada M, Voisin M-B, Scheiermann C, Haskard DO, Dejana E, Krombach F and Nourshargh S (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood  vol. 110, (6) 1848-1856.  

Ley K, Laudanna C, Cybulsky MI and Nourshargh S (2007). Getting to the site of inflammation: the leukocyte adhesion cascade updated. Nat Rev Immunol  vol. 7, (9) 678-689.  

NOURSHARGH S, Krombach F, Dejana E, Khandoga A, Woodfin A, Reichal AC, Haskard DO, Scheiermann C, Voisin MB and Corada M (2007). JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: Evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration. Blood  vol. 110, (6) 1848-1856.  

Young RE, Voisin M-B, Wang S, Dangerfield J and Nourshargh S (2007). Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice. Br J Pharmacol  vol. 151, (5) 628-637.  

Potter PK, Larbi KY, Nourshargh S and Botto M (2007). Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1. Mol Immunol  vol. 44, (6) 1135-1140.  

Voisin M-B and Nourshargh S (2007). Role of α6β1 integrin in leukocyte adhesion and transmigration. Adhesion Molecules: Function and Inhibition  Springer Nature   

Nourshargh S, Krombach F and Dejana E (2006). The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues. J Leukoc Biol  vol. 80, (4) 714-718.  

Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L and Nourshargh S (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. Rockefeller University Press  Journal of Cell Biology  vol. 173, (6) i11-i11.  

Huang M-T, Larbi KY, Scheiermann C, Woodfin A, Gerwin N, Haskard DO and Nourshargh S (2006). ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration. Blood  vol. 107, (12) 4721-4727.  

Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L and Nourshargh S (2006). Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils. J Exp Med  vol. 203, (6) 1519-1532.  

Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu S-Y, Munisamy S, Brainard DM, Mahon MJ, Nourshargh S, van Oudenaarden A, Toner MG and Poznansky MC (2006). Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo. J Leukoc Biol  vol. 79, (3) 539-554.  

Ambrose LR, Little MA, Nourshargh S and Pusey CD (2005). Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy. Kidney Int  vol. 68, (6) 2912-2913.  

Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S and Pusey CD (2005). Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo. Blood  vol. 106, (6) 2050-2058.  

Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ and Perretti M (2005). Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. J Leukoc Biol  vol. 78, (3) 639-646.  

Marelli‐Berg FM and Nourshargh S (2005). Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules. Leukocyte Trafficking  Wiley   

Aurrand-Lions M, Lamagna C, Dangerfield JP, Wang S, Herrera P, Nourshargh S and Imhof BA (2005). Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation. J Immunol  vol. 174, (10) 6406-6415.  

Wang S, Dangerfield JP, Young RE and Nourshargh S (2005). PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration. J Cell Sci  vol. 118, (Pt 9) 2067-2076.  

Nourshargh S and Marelli-Berg FM (2005). Transmigration through venular walls: a key regulator of leukocyte phenotype and function. Trends Immunol  vol. 26, (3) 157-165.  

Dangerfield JP, Wang S and Nourshargh S (2005). Blockade of alpha6 integrin inhibits IL-1beta- but not TNF-alpha-induced neutrophil transmigration in vivo. J Leukoc Biol  vol. 77, (2) 159-165.  

Marelli-Berg FM, James MJ, Dangerfield J, Dyson J, Millrain M, Scott D, Simpson E, Nourshargh S and Lechler RI (2004). Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo. Blood  vol. 103, (8) 3111-3116.  

Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M and Nourshargh S (2004). Neutrophil elastase (NE)-deficient mice demonstrate a nonredundant role for NE in neutrophil migration, generation of proinflammatory mediators, and phagocytosis in response to zymosan particles in vivo. J IMMUNOL  vol. 172, (7) 4493-4502.  

Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ and Botto M (2004). Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis. J Immunol  vol. 172, (6) 3406-3414.  

McMillan SJ, Kearley J, Campbell JD, Zhu X-W, Larbi KY, Shipley JM, Senior RM, Nourshargh S and Lloyd CM (2004). Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation. J Immunol  vol. 172, (4) 2586-2594.  

Yadav R, Larbi KY, Young RE and Nourshargh S (2003). Migration of leukocytes through the vessel wall and beyond. THROMBOSIS AND HAEMOSTASIS  vol. 90, (4) 598-606.  

James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D, Simpson E, Cardozo L, Warrens A, Szydlo RM, Lechler RI and Marelli-Berg FM (2003). Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism. Blood  vol. 102, (6) 2173-2179.  

Marshall D, Dangerfield JP, Bhatia VK, Larbi KY, Nourshargh S and Haskard DO (2003). MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha. Rheumatology (Oxford)  vol. 42, (8) 929-934.  

Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ and Nourshargh S (2003). P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses. J Leukoc Biol  vol. 73, (1) 65-73.  

Young RE, Thompson RD and Nourshargh S (2002). Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules. Br J Pharmacol  vol. 137, (8) 1237-1246.  

Dangerfield J, Larbi KY, Huang M-T, Dewar A and Nourshargh S (2002). PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane. J Exp Med  vol. 196, (9) 1201-1211.  

Marshall D, Dangerfield JD, Bhatia VK, Larbi KY, Nourshargh S and Haskard DO (2002). MRL/lpr LUPUS-PRONE MICE SHOW EXAGGERATED ICAM-1 DEPENDENT LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN RESPONSE TO TNF alpha. RHEUMATOLOGY  vol. 41, 32-32.  

Young RE, Thompson RD and Nourshargh S (2002). Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta (IL-1 beta) and factor-alpha (TNF alpha) in mouse cremasteric venules. BRIT J PHARMACOL  vol. 135,  

Thompson RD, Noble KE, Larbi KY, Dewar A, Duncan GS, Mak TW and Nourshargh S (2001). Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane. Blood  vol. 97, (6) 1854-1860.  

Marshall D, Bhatia VK, Ahmed S, Lidington EA, Larbi KY, Nourshargh S and Haskard DO (2001). Expression of P- but not E-selectin in peritoneal microvasculature during inflammatory peritonitis. FASEB J  vol. 15, (4) A328-A328.  

Larbi KY, Allen AR, Tam FWK, Haskard DO, Lobb RR, Silva PMR and Nourshargh S (2000). VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration. American Society of Hematology  Blood  vol. 96, (10) 3601-3609.  

Asimakopoulos G, Thompson R, Nourshargh S, Lidington EA, Mason JC, Ratnatunga CP, Haskard DO, Taylor KM and Landis RC (2000). An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation. Elsevier  Journal of Thoracic and Cardiovascular Surgery  vol. 120, (2) 361-369.  

Thompson RD, Wakelin MW, Larbi KY, Dewar A, Asimakopoulos G, Horton MA, Nakada MT and Nourshargh S (2000). Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and β3 Integrin Blockade on Leukocyte Transmigration In Vivo. The American Association of Immunologists  The Journal of Immunology  vol. 165, (1) 426-434.  

DAVIES¶ , LARBI , ALLEN , SANZ , WEG , HASKARD , LOBB and NOURSHARGH (1999). VCAM‐1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM‐1 in rat skin. Wiley  Immunology  vol. 97, (1) 150-158.  

NAGAI , LARKIN§ , HARTNELL , LARBI , AGHAKHANI R, WINDLEY , DAVIES , LOBB , WILLIAMS and NOURSHARGH (1999). Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of α4 integrins and vascular cell adhesion molecule‐1. Wiley  Immunology  vol. 96, (2) 176-183.  

Sanz M-J, Marinova-Mutafchieva L, Green P, Lobb RR, Feldmann M and Nourshargh S (1998). IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways. The American Association of Immunologists  The Journal of Immunology  vol. 160, (11) 5637-5645.  

Sanz M-J, Ponath PD, Mackay CR, Newman W, Miyasaka M, Tamatani T, Flanagan BF, Lobb RR, Williams TJ, Nourshargh S and Jose PJ (1998). Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4. The American Association of Immunologists  The Journal of Immunology  vol. 160, (7) 3569-3576.  

Wakelin MW and Nourshargh S (1997). TNFα and IFNγ act synergistically to induce leukocyte rolling and adhesion but not extravasation in vivo. FASEB Journal  vol. 11, (3)  

Sanz M-J, Hartnell A, Chisholm P, Williams C, Davies D, Weg VB, Feldmann M, Bolanowski MA, Lobb RR and Nourshargh S (1997). Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways. American Society of Hematology  Blood  vol. 90, (10) 4144-4152.  

Wakelin MW, Sanz MJ, Dewar A, Albelda SM, Larkin SW, Boughton-Smith N, Williams TJ and Nourshargh S (1996). An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane. Rockefeller University Press  Journal of Experimental Medicine  vol. 184, (1) 229-239.  

Nourshargh S and Williams TJ (1995). Molecular and cellular interactions mediating granulocyteaccumulation in vivo. Elsevier  Seminars in Cell and Developmental Biology  vol. 6, (6) 317-326.  

Nourshargh S, Larkin SW, Das A and Williams TJ (1995). Interleukin-1-Induced Leukocyte Extravasation Across Rat Mesenteric Microvessels Is Mediated by Platelet-Activating Factor. American Society of Hematology  Blood  vol. 85, (9) 2553-2558.  

Walsh DT, Weg VB, Williams TJ and Nourshargh S (1995). Substance P‐induced inflammatory responses in guinea‐pig skin: The effect of specific NK1 receptor antagonists and the role of endogenous mediators. Wiley  British Journal of Pharmacology  vol. 114, (7) 1343-1350.  

Sanz MJ, Weg VB, Bolanowski MA and Nourshargh S (1995). IL-1 is a potent inducer of eosinophil accumulation in rat skin. Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody. The American Association of Immunologists  The Journal of Immunology  vol. 154, (3) 1364-1373.  

Weg VB, Walsh DT, Faccioli LH, Williams TJ, Feldmann M and Nourshargh S (1995). LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha. Immunology  vol. 84, (1) 36-40.  

Das AM, Williams TJ, Lobb R and Nourshargh S (1995). Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model. Immunology  vol. 84, (1) 41-46.  

Sanz MJ, Weg VB, Walsh DT, Williams TJ and Nourshargh S (1994). Differential effects of the PAF receptor antagonist UK‐74,505 on neutrophil and eosinophil accumulation in guinea‐pig skin. Wiley  British Journal of Pharmacology  vol. 113, (2) 513-521.  

Pons F, Rossi AG, Norman KE, Williams TJ and Nourshargh S (1993). Role of platelet‐activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long‐acting PAF antagonist, UK‐74,505. Wiley  British Journal of Pharmacology  vol. 109, (1) 234-242.  

Yarwood H, Nourshargh S, Brain S and Williams TJ (1993). Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action. Wiley  British Journal of Pharmacology  vol. 108, (4) 959-966.  

Weg VB, Williams TJ, Lobb RR and Nourshargh S (1993). A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo. Rockefeller University Press  Journal of Experimental Medicine  vol. 177, (2) 561-566.  

von Uexküll C, Nourshargh S and Williams TJ (1992). Comparative responses of human and rabbit interleukin-1 in vivo: effect of a recombinant interleukin-1 receptor antagonist. Immunology  vol. 77, (4) 483-487.  

Nourshargh S, Perkins JA, Showell HJ, Matsushima K, Williams TJ and Collins PD (1992). A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8. The American Association of Immunologists  The Journal of Immunology  vol. 148, (1) 106-111.  

Seale JP, Nourshargh S, Hellewell PG and Williams TJ (1991). Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung. Wiley  British Journal of Pharmacology  vol. 104, (1) 251-257.  

WILLIAMS TJ, DAS A, von UEXKULL C and NOURSHARGH S (1991). Neutrophils in Asthmaa. Wiley  Annals of the New York Academy of Sciences  vol. 629, (1) 73-81.  

Faccioli LH, Nourshargh S, Moqbel R, Williams FM, Sehmi R, Kay AB and Williams TJ (1991). The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo. Immunology  vol. 73, (2) 222-227.  

Nourshargh S and Williams TJ (1990). Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo. The American Association of Immunologists  The Journal of Immunology  vol. 145, (8) 2633-2638.  

Nourshargh S, Rampart M, Hellewell PG, Jose PJ, Harlan JM, Edwards AJ and Williams TJ (1989). Accumulation of 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen. The American Association of Immunologists  The Journal of Immunology  vol. 142, (9) 3193-3198.  

Williams TJ, Brain SD, Hellewell PG, Jose PJ, Nourshargh S and Rampart M (1988). Alteration in microvascular permeability induced by products released during inflammation. Progress in Clinical and Biological Research  vol. 263, 55-69.  

Nourshargh S and Hoult JRS (1987). Divergent effects of co‐carcinogenic phorbol esters and a synthetic diacylglycerol on human neutrophil chemokinesis and granular enzyme secretion. Wiley  British Journal of Pharmacology  vol. 91, (3) 557-568.  

Nourshargh S and Hoult JRS (1986). Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors. Elsevier  European Journal of Pharmacology  vol. 122, (2) 205-212.  

Hoult JRS and Nourshargh S (1985). Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis. Wiley  British Journal of Pharmacology  vol. 86, (3) 533-537.