Prof Simon Rawlinson
Reader in Dental Hard Tissue Biology
Dentistry
Queen Mary University of London
Queen Mary University of London
Research
Bone, Mechanobiology, Strain, Shear
Interests
Interest in further developing in vitro models to best replicate forces engendered in bone by mechanical loadingPublications
2024
Shahdad S, Rawlinson S, Razaghi N, Patankar A, Patel M, Roccuzzo M and Gill T (2024). Osseointegration of Anodized vs. Sandblasted Implant Surfaces in a Guided Bone Regeneration Acute Dehiscence‐Type Defect: An In Vivo Experimental Mandibular Minipig Model. Wiley Clinical Oral Implants Research Al-Noaman A and Rawlinson SCF (2024). A bioactive and anti-bacterial nano-sized zirconium phosphate/GO (nZrP/GO) composite: Potential use as a coating for dental implants? Elsevier Dental Materials Gill T, Kühl S, Rawlinson S, Pippenger B, Bellon B and Shahdad S (2024). Primary stability and osseointegration comparing a novel tapered design tissue‐level implant with a parallel design tissue‐level implant. An experimental in vivo study. Wiley Clinical Oral Implants Research vol. 35, (9) 1114-1127. D'Onofrio A, Hill RG, Kent NW, Rawlinson SCF and Shahdad SA (2024). Development of a Novel Formulation of Bioactive Glass Based Calcium Phosphate Cement for Bone Grafting. Wiley Advanced Functional Materials vol. 34, (36) 2023
Al-Noaman AS and Rawlinson SF (2023). Titanium Dioxide/Graphene Oxide Composite Coatings for 316 Stainless Steel Dental Implants. European Journal of Prosthodontics and Restorative Dentistry vol. 31, (4) 358-372. Al‐Noaman A and Rawlinson SCF (2023). Polyether ether ketone coated with nanohydroxyapatite/graphene oxide composite promotes bioactivity and antibacterial activity at the surface of the material. Wiley European Journal Of Oral Sciences vol. 131, (5-6) Al‐Noaman A and Rawlinson SCF (2023). A novel bioactive glass/graphene oxide composite coating for a polyether ether ketone‐based dental implant. Wiley European Journal Of Oral Sciences vol. 131, (2) 2021
Al-Noaman A, Rawlinson SCF and Hill RG (2021). MgF2- containing glasses as a coating for titanium dental implant. I- Glass powder. Elsevier Journal of the Mechanical Behavior of Biomedical Materials vol. 125, 2020
Rawlinson SCF (2020). Mechanobiology Journal —Welcome Editorial. Bendola S.p.r.L - BVBA Mechanobiology Journal vol. 1, 1-1. 2019
Caetano-Silva SP, Novicky A, Javaheri B, Rawlinson SCF and Pitsillides AA (2019). Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation. Bone Research Protocols Springer Nature 2018
Liu J, Zheng F, Rawlinson SCF, Fortune F and Kim DG (2018). Bone biology and bioactive glass in bone regeneration. Bone Regeneration: Concepts, Clinical Aspects and Future Directions Gharibi B, Ghuman MS, Cama G, Rawlinson SCF, Grigoriadis AE and Hughes FJ (2018). Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression. Elsevier Molecular and Cellular Endocrinology vol. 477, 140-147. 2017
Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA (2017). Corrigendum: Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Cell Biochem Funct vol. 35, (4) 244-244. Huang M, Hill RG and Rawlinson SCF (2017). Zinc bioglasses regulate mineralization in human dental pulp stem cells. Elsevier Dental Materials vol. 33, (5) 543-552. RAWLINSON SCF (2017). Mechanical responsiveness of distinct skeletal elements – possible exploitation of low weight-bearing bone. Mechanobiology: Exploitation for Medical Benefit Wiley Blackwell Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA (2017). Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Wiley Cell Biochemistry and Function vol. 35, (1) 56-65. 2016
Rawlinson SCF (2016). Mechanical Responsiveness of Distinct Skeletal Elements. Mechanobiology Wiley Liu J, Rawlinson S, Hill R and FORTUNE F (2016). Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects. Elsevier Dental Materials vol. 32, (10) e221-e237. Huang M, Hill RG and Rawlinson SCF (2016). Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair? Elsevier Acta Biomaterialia Liu J, Rawlinson SCF, Hill RG and Fortune F (2016). Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects. Elsevier Dental Materials vol. 32, (3) 412-422. 2015
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH (2015). Microscopy and supporting data for osteoblast integration within an electrospun fibrous network. Elsevier Data in Brief vol. 5, 775-781. Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH (2015). 3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration. Elsevier/Science Direct Acta Biomaterialia vol. 27, 88-100. Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF and Allaker RP (2015). Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants. Journal of Biomedical Materials Research - Part A vol. 103, (3) 981-989. 2014
Huang M, Rawlinson SCF and Hill RG (2014). Interactions of strontium with the dentine-pulp complex. Elsevier Dental Materials vol. 30, e176-e177. 2013
Kingsmill VJ, McKay IJ, Ryan P, Ogden MR and Rawlinson SCF (2013). Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat. J Dent vol. 41, (3) 258-264. Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II— Composite coating. Journal of Non-Crystalline Solids vol. 364, 99-106. Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder. Journal of Non-Crystalline Solids vol. 364, 92-98. Al-Noaman A, Rawlinson SCF and Hill RG (2013). Bioactive glass-stoichimetric wollastonite glass alloys to reduce TEC of bioactive glass coatings for dental implants. MATERIALS LETTERS vol. 94, 69-71. Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating. JOURNAL OF NON-CRYSTALLINE SOLIDS vol. 364, 85-91. 2012
Al-Noaman A, Rawlinson SCF and Hill RG (2012). The influence of CaF2 content on the physical properties and apatite formation of bioactive glass coatings for dental implants. JOURNAL OF NON-CRYSTALLINE SOLIDS vol. 358, (15) 1850-1858. Al-Noaman A, Rawlinson SCF and Hill RG (2012). The role of MgO on thermal properties, structure and bioactivity of bioactive glass coating for dental implants. JOURNAL OF NON-CRYSTALLINE SOLIDS vol. 358, (22) 3019-3027. 2011
Pitsillides AA and Rawlinson SCF (2011). Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation. Springer Nature Methods in Molecular Biology vol. 816, 593-619. 2010
Kingsmill VJ, Boyde A, Davis GR, Howell PGT and Rawlinson SCF (2010). Changes in bone mineral and matrix in response to a soft diet. J Dent Res vol. 89, (5) 510-514. 2009
Rawlinson SCF, Mckay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ and Kingsmill VJ (2009). Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development. PLOS ONE vol. 4, (12) Rawlinson SCF, Murray DH, Mosley JR, Wright CDP, Bredl JC, Saxon LK, Loveridge N, Leterrier C, Constantin P, Farquharson C and Pitsillides AA (2009). Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading. BONE vol. 45, (2) 357-366. Rawlinson SCF, Boyde A, Davis GR, Howell PGT, Hughes FJ and Kingsmill VJ (2009). Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone. J DENT RES vol. 88, (7) 615-620. Rawlinson SCF, McKay IJ, Ghuman M, Wellmann C, Hughes FJ and Kingsmill VJ (2009). POST-MENOPAUSAL OSTEOPOROSIS-RESISTANT SKULL BONES – GENOTYPICALLY DISTINCT FROM OSTEOPOROTIC-SUSCEPTIBLE LIMB BONE. Elsevier Maturitas vol. 63, 2008
Simon DWN, Clarkin CE, Das-Gupta V, Rawlinson SCF, Emery RJ and Pitsillides AA (2008). Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. J BONE JOINT SURG BR vol. 90B, (5) 680-684. 2005
De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE and Pitsillides AA (2005). Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. BONE vol. 37, (6) 810-818. 2004
Chambler A, Rawlinson S, Emery R and Pitsillides A (2004). Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament. The Journal of Rheumatology vol. 31, (11) 2216-2225. Jessop HL, Suswillo RFL, Rawlinson SCF, Zaman G, Lee K, Das-Gupta V, Pitsillides AA and Lanyon LE (2004). Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J BONE MINER RES vol. 19, (6) 938-946. 2003
Pitsillides AA, Das-Gupta V, Simon D and Rawlinson SCF (2003). Methods for Analyzing Bone Cell Responses to Mechanical Loading Using In Vitro Monolayer and Organ Culture Models. Bone Research Protocols Springer Nature PITSILLIDES AA, DAS-GUPTA V, SIMON D and RAWLINSON SCF (2003). Methods for analyzing bone cell responses to mechanical loading using in vitro monolayer and organ culture models. BONE RESEARCH PROTOCOLS (METHODS IN MOLECULAR MEDICINE) , Editors: RALSTON MHS. HUMANA PRESS 2002
Jessop HL, Rawlinson SCF, Pitsillides AA and Lanyon LE (2002). Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. BONE vol. 31, (1) 186-194. Pitsillides AA, Rawlinson SCF, Wright CPD, Bredl J, Mosley JR and Lanyon LE (2002). Differing architectural designs achieve similar load-bearing resistance in genetically distinct strains of chick. J BONE MINER RES vol. 17, (5) 953-953. Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ and Lanyon LE (2002). Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J BONE MINER RES vol. 17, (4) 593-602. 2000
Rawlinson SC, Wheeler-Jones CP and Lanyon LE (2000). Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2). 1999
Cheng MZ, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ and Lanyon LE (1999). ROS cells proliferate in response to estrogen through IGF-I and mechanical strain through IGF-II. J BONE MINER RES vol. 14, (6) 1032-1032. Cheng M, Zaman G, Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE (1999). Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I. Pitsillides AA, Rawlinson SC, Mosley JR and Lanyon LE (1999). Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability. Zaman G, Pitsillides AA, Rawlinson SC, Suswillo RF, Mosley JR, Cheng MZ, Platts LA, Hukkanen M, Polak JM and Lanyon LE (1999). Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. 1998
Rawlinson SC, Zaman G, Mosley JR, Pitsillides AA and Lanyon LE (1998). Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo. 1997
Rawlinson SCF, Pitsillides AA, Zaman G and Lanyon LE (1997). Effect of exogenous carbon monoxide on loading-related pre-osteogenic responses. J BONE MINER RES vol. 12, (9) P13-P13. Cheng MZ, Zaman G, Rawlinson SC, Pitsillides AA, Suswillo RF and Lanyon LE (1997). Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae. Hukkanen M, Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Platts LAM, Polak JM and Lanyon LE (1997). A putative role for osteocyte eNOS-derived NO in adaptive bone remodelling. J PATHOL vol. 181, A42-A42. 1996
Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Hukkanen M, Platts L, Polak JM and Lanyon LE (1996). A putative role for osteocyte eNOS-derived NO in adaptive bone (re)modelling: An extension to an endothelial paradigm. International Journal of Experimental Pathology vol. 77, (6) Pitsillides AA, Rawlinson SCF and Lanyon LE (1996). P10. Early responses to mechanical load in selectively-bred embryonic chicks differ. Elsevier Bone vol. 19, (6) Rawlinson SCF, Zaman G, Pitsillides AA and Lanyon LE (1996). A possible role for carbon monoxide in the adaptive response of bone cells to dynamic mechanical loading. J BONE MINER RES vol. 11, (11) P8-P8. Cheng MZ, Zaman G, Rawlinson SC, Suswillo RF and Lanyon LE (1996). Mechanical loading and sex hormone interactions in organ cultures of rat ulna. Rawlinson SC, Pitsillides AA and Lanyon LE (1996). Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. 1995
Rawlinson SCF, Pitsillides AA and Lanyon LE (1995). Strain measurement by bone cells during mechanical loading. Elsevier Bone vol. 17, (3) PITSILLIDES AA, RAWLINSON SCF, SUSWILLO RFL, ZAMAN G, NIJWEIDE PI and LANYON LE (1995). MECHANICAL STRAIN-INDUCED NITRIC-OXIDE PRODUCTION BY OSTEOBLASTS AND OSTEOCYTES. J BONE MINER RES vol. 10, S217-S217. RAWLINSON SCF, PITSILLIDES AA and LANYON LE (1995). MECHANODEPENDENT SIGNALING PATHWAYS IN OSTEOCYTES AND OSTEOBLASTS. J BONE MINER RES vol. 10, S342-S342. CHENG MZ, ZAMAN G, RAWLINSON SCF, SUSWILLO RFL and LANYON LE (1995). MECHANICAL LOADING, PROSTAGLANDIN AND SEX-HORMONE INTERACTIONS IN MALE AND FEMALE RAT ULNAE IN CULTURE. J BONE MINER RES vol. 10, S342-S342. Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G and Lanyon LE (1995). Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? Rawlinson SC, Mosley JR, Suswillo RF, Pitsillides AA and Lanyon LE (1995). Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. 1993
Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE (1993). Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. 1992
RAWLINSON SCF, MOHAN S, BAYLINK DJ and LANYON LE (1992). LOAD-RELATED OSTEOGENESIS, PROSTACYCLIN AND IGF-II. J BONE MINER RES vol. 7, S141-S141. 1991
Rawlinson SC, el-Haj AJ, Minter SL, Tavares IA, Bennett A and Lanyon LE (1991). Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? 1990
EL-HAJ AJ, MINTER SL, RAWLINSON SCF, SUSWILLO RFL and LANYON LE (1990). Cellular responses to mechanical loading in vitro. J BONE MINER RES vol. 5, (9) 923-932. Grants
KTP AKT (QMUL-Lucideon) - Radio Opaque Cements and Osteoclast Testing: Traceable Bio-Remodellable CementsKarin Hing and Simon Rawlinson
£41,283 Innovate UK (25-03-2024 - 24-07-2024)
KTP with Lucideon: Cell testing to assist development of novel biomaterialsKarin Hing and Simon Rawlinson
£256,237 Innovate UK (17-02-2021 - 17-02-2024)