Dr Tina Chowdhury
Reader in Regenerative Medicine
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Regenerative medicine, Infection, Inflammation, Mechanobiology
Interests
We are developing novel therapeutics to slow down inflammation and repair damage to human tissues with the vision of restoring normal function. We use multi-disciplinary tools involving engineering, materials and biology to investigate the effects of stress eg. cytokines, heat, environment on inflammatory signalling pathways. Human tissues include placenta, membranes, cartilage and disc. Our research efforts are focused on translational investigation with the aim of delivering novel therapeutics that restore a healthy ageing phenotype. For example, Tina Chowdhury is Chief Investigator for a clinical trial (NCT06340971) investigating how the environment affects pregnancy outcomes and preterm birth (REC 24/EE/0047) with the clinical teams at UCLH NHS Trust (Anna David) and Barts Health NHS Trust (Stamatina Iliodromiti).Publications of specific relevance to Predictive in vitro Models
2023
Costa E, Thrasivoulou C, Becker DL, Deprest JA, David AL and Chowdhury TT (2023). Cx43 regulates mechanotransduction mechanisms in human preterm amniotic membrane defects. Wiley Prenatal Diagnosis Arain Z, Iliodromiti S, Slabaugh G, David AL and Chowdhury TT (2023). Machine learning and disease prediction in obstetrics. Elsevier Current Research in Physiology vol. 6, 2021
Costa E, Okesola BO, Thrasivoulou C, Becker DL, Deprest JA, David AL and Chowdhury TT (2021). Cx43 mediates changes in myofibroblast contraction and collagen release in human amniotic membrane defects after trauma. Springer Nature Scientific Reports vol. 11, (1) Meng H, Chowdhury TT and Gavara N (2021). The Mechanical Interplay Between Differentiating Mesenchymal Stem Cells and Gelatin-Based Substrates Measured by Atomic Force Microscopy. Frontiers Frontiers in Cell and Developmental Biology vol. 9, 2020
Barrett DW, Okesola BO, Costa E, Thrasivoulou C, Becker DL, Mata A, Deprest JA, David AL and Chowdhury TT (2020). Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisense. Wiley Prenatal Diagnosis vol. 41, (1) 89-99. Derkus B, Okesola BO, BARRETT DW, D’Este M, Chowdhury TT, Eglin D and Mata A (2020). Multicomponent hydrogels for the formation of vascularized bone-like constructs in vitro. Elsevier Acta Biomaterialia Dawsmith W, Ohtani N, Donnan R, Naftaly M, Dudley RA and Chowdhury TT (2020). Microwave Frequency Dependent Dielectric Properties of Blood as a Potential Technique to Measure Hydration. Institute of Electrical and Electronics Engineers (IEEE) IEEE Access 1-1. Read JE, Luo D, Chowdhury TT, Flower RJ, Poston RN, Sukhorukov GB and Gould DJ (2020). Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS production. Royal Society of Chemistry (RSC) Nanoscale vol. 12, (14) 7735-7748. 2019
Chowdhury TT, Barrett DW and David AL (2019). Strategies to Repair Defects in the Fetal Membrane. Fetal Therapy Cambridge University Press (CUP) BARRETT DW, John RK, Thrasivoulou C, MATA A, Deprest JA, Becker DL, David AL and CHOWDHURY TINA (2019). Targeting mechanotransduction
mechanisms and tissue weakening
signals in the human amniotic
membrane. Nature Publishing Group Scientific Reports 2018
Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Pranpanus S, Barrett DW, Connon C, Chowdhury TT, David AL and Deprest J (2018). Corrigendum for Engels, Joyeux, Van der Merwe, et al. (2017) DOI: 10.1002/pd.5191. Wiley Prenatal Diagnosis vol. 38, (6) 471-471. 2017
Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Prapanus S, Barrett DW, Connon C, Chowdhury TT, David AL and Deprest J (2017). Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model. Wiley Prenatal Diagnosis vol. 38, (2) 99-105. Barrett DW, Kethees A, Thrasivoulou C, Mata A, Virasami A, Sebire NJ, Engels AC, Deprest JA, Becker DL, David AL and Chowdhury TT (2017). Trauma induces overexpression of Cx43 in human fetal membrane defects. Prenatal Diagnosis vol. 37, (9) 899-906. 2016
Barrett DW, David AL, Thrasivoulou C, Mata A, Becker DL, Engels AC, Deprest JA and Chowdhury TT (2016). Connexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgery. Prenatal Diagnosis vol. 36, (10) 942-952. Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT (2016). Oxygen tension modulates the effects of TNFα in compressed chondrocytes. Inflamm Res 2015
Hossain MA, Chowdhury T and Bagul A (2015). Imaging modalities for the in vivo surveillance of mesenchymal stromal cells. J Tissue Eng Regen Med vol. 9, (11) 1217-1224. Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ and Chowdhury TT (2015). C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Elsevier Biochemical and Biophysical Research Communications vol. 465, (4) 784-789. Peake N, Pavlov A, D'Souza A, Alfasahin I, Pingaan-Murphy B, Sukhurukov G, Hobbs A and Chowdhury T (2015). Polyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damage. Elsevier Osteoarthritis and Cartilage vol. 23, a141-a142. Peake NJ, Pavlov AM, D'Souza A, Pingguan-Murphy B, Sukhorukov GB, Hobbs AJ and CHOWDHURY TT (2015). Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants. American Chemical Society Biomacromolecules 2014
Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and Chowdhury TT (2014). Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function. Osteoarthritis Cartilage vol. 22, (11) 1800-1807. Chowdhury B, David AL, Thrasivoulou C, Becker DL, Bader DL and Chowdhury TT (2014). Tensile strain increased COX-2 expression and PGE2 release leading to weakening of the human amniotic membrane. Elsevier Placenta vol. 35, (12) 1057-1064. Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and CHOWDHURY TT (2014). Role of C-type natriuretic peptide signaling in maintaining cartilage and bone function. Elsevier/Science Direct Osteoarthritis and Cartilage vol. online edition, Hossain MA, CHOWDHURY TT and Bagul A (2014). Imaging modalities for the in vivo surveillance of mesenchymal stromal cells. Wiley Journal of Tissue Engineering and Regenerative Medicine Chowdhury B, David A, Bader D, Thrasivoulou C, Becker D and Chowdhury T (2014). PFM.37 Cyclic tensile strain increases PGE2 release leading to weakening of the human term amniotic membrane. BMJ Archives of Disease in Childhood Fetal & Neonatal vol. 99, (Suppl 1) Parker E, Vessillier S, Abas WW, Bader DL, Pinguaan-Murphy B and Chowdhury TT (2014). α5β1 integrin mediates compression-induced inhibition of catabolic effects induced by fibronectin fragments in an oxygen-dependent manner. Elsevier Osteoarthritis and Cartilage vol. 22, 2013
Parker E, Vessillier S, Pinguaan-Murphy B, Wan Abas WAB, Bader DL and Chowdhury TT (2013). Low oxygen tension increased FN-f induced catabolic activities - response prevented with biomechanical signals. BioMed central Arthritis Research and Therapy vol. 15, (5) R163-R163. Akanji O, Salter DM and Chowdhury TT (2013). Optimisation of quantitative real-time PCR studies in cartilage mechanobiology. PCR Technology. Current innovations , Editors: Nolan T and Bustin SA. CRC PressI Llc Parker E, Pinguuan-Murphy B, Bader DL and Chowdhury TT (2013). FN-f induced catabolic activities are dependent on oxygen tension in chondrocyte/agarose constructs subjected to biomechanical signals. Elsevier Osteoarthritis and Cartilage vol. 21, Hossain MA, Frampton AE, Chowdhury TT and Morsey M (2013). Biological vascular grafts for hemodialysis access. Informa healthcare Expert Rev Med Devices vol. 2, (10) 171-175. Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ and Chowdhury TT (2013). Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor model. Bio Med Central Arthritis Research and Therapy vol. 15, (4) Akanji O, Salter D and Chowdhury T (2013). Optimization of Quantitative Real-Time PCR for Studies in Cartilage Mechanobiology. PCR Technology: Current Innovations, Third Edition 2012
CHOWDHURY TT, Tilwani RK and Bader DL (2012). Biomechanical conditioning enhanced matrix synthesis in nucleus pulposus cells cultured in agarase constructs with TGFβ., Editors: Goldsmith EC and Lin SK. Journal Functional Biomaterials vol. 3, 23-26. 2011
Ramachandran M, Achan P, Salter DM, Bader DL and Chowdhury TT (2011). Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructs. Arthritis Research and Therapy vol. 13, (5) Bader DL, Salter DM and Chowdhury TT (2011). Biomechanical influence of cartilage homeostasis in health and disease. Arthritis vol. 2011, Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT (2011). Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs. Methods Mol Biol vol. 695, 77-97. 2010
Chowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A and Homandberg GA (2010). Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructs. Arthritis Research and Therapy vol. 12, (3) McGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S and Poole CA (2010). Mechanical loading modulates chondrocyte primary cilia incidence and length. Cell Biology International vol. 34, (5) 441-446. Akanji OO, Sakthithasan P, Salter DM and Chowdhury TT (2010). Dynamic compression alters NFκB activation and IκB-α expression in IL-1β-stimulated chondrocyte/agarose constructs. Inflammation Research vol. 59, (1) 41-52. 2009
Akanji OO, Salter DM and Chowdhury TT (2009). 458 DYNAMIC COMPRESSION ALTERS NF?B ACTIVATION AND I?B-α EXPRESSION IN IL-1β STIMULATED CHONDROCYTE/AGAROSE CONSTRUCTS. Elsevier Osteoarthritis and Cartilage vol. 17, s245-s246. Raveenthiran SP and Chowdhury TT (2009). Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructs. Biomechanics and Modeling in Mechanobiology vol. 8, (4) 273-283. 2008
Raveenthiran SP and Chowdhury TT (2008). 451 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN-FRAGMENT INDUCED INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS. Elsevier Osteoarthritis and Cartilage vol. 16, s195-s196. Chowdhury TT, Salter DM, Bader DL and Lee DA (2008). Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compression. INFLAMM RES vol. 57, (7) 306-313. CHOWDHURY TT, Akanjii OO, Salter DM and Lee DA (2008). Dynamic compression influences IL-1β induced NO and PGE2 release, via alterations in iNOS and COX-2 activity. 5th International Symposium on Mechanobiology of Cartilage and Chondrocyte , Editors: Stoltz JF. Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA (2008). Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs. Arthritis Res Ther vol. 10, (2) Chowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA (2008). Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expression. BIORHEOLOGY vol. 45, (3-4) 257-274. 2007
Chowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL and Lee DA (2007). 52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSION. Elsevier Osteoarthritis and Cartilage vol. 15, c42-c43. Campbell JJ, Blain EJ, Chowdhury TT and Knight MM (2007). Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytes. Biochemical and Biophysical Research Communications vol. 361, (2) 329-334. 2006
Chowdhury TT and Knight MM (2006). Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compression. Journal of Cellular Physiology vol. 209, (3) 845-853. Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA (2006). Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes. Biomech Model Mechanobiol vol. 5, (2-3) 192-201. Chowdhury TT, Bader DL and Lee DA (2006). Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes. Biochem Biophys Res Commun vol. 339, (1) 241-247. CHOWDHURY TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1β induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Mechanobiology: Cartilage and Chondrocyte , Editors: Stoltz JF. IOS Press Chowdhury TT, Bader DL and Lee DA (2006). Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Biorheology vol. 43, (3,4) 413-429. Chowdhury TT, Raveenthiran SP, Bader DL and Lee DA (2006). P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDE. Elsevier Osteoarthritis and Cartilage vol. 14, 2005
Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 251-252. Chowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA (2005). Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructs. Proceedings of the 2005 Summer Bioengineering Conference vol. 2005, 545-546. Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2) Catuogno C, Chowdhury TT, Bader DL and Lee DA (2005). Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructs. European Cells and Materials vol. 10, (SUPPL.2) (2005). British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UK. Wiley International Journal of Experimental Pathology vol. 86, (3) a1-a56. 2004
Chowdhury TT, Salter DM, Bader DL and Lee DA (2004). Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes. Biochem Biophys Res Commun vol. 318, (4) 873-881. Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS (2004). Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels. Ann Biomed Eng vol. 32, (3) 407-417. 2003
Chowdhury TT, Bader DL, Shelton JC and Lee DA (2003). Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression. Arch Biochem Biophys vol. 417, (1) 105-111. Chowdhury TT, Bader DL and Lee DA (2003). Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs. Osteoarthritis Cartilage vol. 11, (9) 688-696. Chowdhury TT, Shelton JC, Bader DL and LEE DA (2003). Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs. Internat. J. Artificial Organs vol. 26, (9) 858-858. Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL (2003). alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression. Osteoarthritis Cartilage vol. 11, (Suppl 1) S2-S3. 2001
Chowdhury TT, Bader DL and Lee DA (2001). Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs. Biochem Biophys Res Commun vol. 285, (5) 1168-1174. 2000
Chowdhury TT, Bader DL and Lee DA (2000). Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructs. Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell 