Dr Tina Chowdhury
Reader in Regenerative Medicine
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Regenerative medicine, Infection, Inflammation, Mechanobiology
Interests
We are developing novel therapeutics to slow down inflammation and repair damage to human tissues with the vision of restoring normal function. We use multi-disciplinary tools involving engineering, materials and biology to investigate the effects of stress eg. cytokines, heat, environment on inflammatory signalling pathways. Human tissues include placenta, membranes, cartilage and disc. Our research efforts are focused on translational investigation with the aim of delivering novel therapeutics that restore a healthy ageing phenotype. For example, Tina Chowdhury is Chief Investigator for a clinical trial (NCT06340971) investigating how the environment affects pregnancy outcomes and preterm birth (REC 24/EE/0047) with the clinical teams at UCLH NHS Trust (Anna David) and Barts Health NHS Trust (Stamatina Iliodromiti).Publications of specific relevance to Predictive <em>in vitro</em> Models
2024
Role of Myofibroblasts in the Repair of Iatrogenic Preterm Membranes Subjected to Mechanical StimulationCosta E, Thrasivoulou C, Becker DL, Deprest J, David AL and Chowdhury TT
Prenatal Diagnosis, Wiley
04-12-2024
2023
Cx43 regulates mechanotransduction mechanisms in human preterm amniotic membrane defectsCosta E, Thrasivoulou C, Becker DL, Deprest JA, David AL and Chowdhury TT
Prenatal Diagnosis, Wiley
30-08-2023
Machine learning and disease prediction in obstetricsArain Z, Iliodromiti S, Slabaugh G, David AL and Chowdhury TT
Current Research in Physiology, Elsevier vol. 6
01-01-2023
2021
Cx43 mediates changes in myofibroblast contraction and collagen release in human amniotic membrane defects after traumaCosta E, Okesola BO, Thrasivoulou C, Becker DL, Deprest JA, David AL and Chowdhury TT
Scientific Reports, Springer Nature vol. 11 (1)
18-08-2021
The Mechanical Interplay Between Differentiating Mesenchymal Stem Cells and Gelatin-Based Substrates Measured by Atomic Force MicroscopyMeng H, Chowdhury TT and Gavara N
Frontiers in Cell and Developmental Biology, Frontiers vol. 9
21-06-2021
2020
Potential sealing and repair of human FM defects after trauma with peptide amphiphiles and Cx43 antisenseBarrett DW, Okesola BO, Costa E, Thrasivoulou C, Becker DL, Mata A, Deprest JA, David AL and Chowdhury TT
Prenatal Diagnosis, Wiley vol. 41 (1), 89-99.
12-10-2020
Multicomponent hydrogels for the formation of vascularized bone-like constructs in vitroDerkus B, Okesola BO, BARRETT DW, D’Este M, Chowdhury TT, Eglin D and Mata A
Acta Biomaterialia, Elsevier
01-06-2020
Microwave Frequency Dependent Dielectric Properties of Blood as a Potential Technique to Measure HydrationDawsmith W, Ohtani N, Donnan R, Naftaly M, Dudley RA and Chowdhury TT
Ieee Access, Institute of Electrical and Electronics Engineers (Ieee), 1-1.
02-03-2020
Magnetically responsive layer-by-layer microcapsules can be retained in cells and under flow conditions to promote local drug release without triggering ROS productionRead JE, Luo D, Chowdhury TT, Flower RJ, Poston RN, Sukhorukov GB and Gould DJ
Nanoscale, Royal Society of Chemistry (Rsc) vol. 12 (14), 7735-7748.
01-01-2020
2019
Strategies to Repair Defects in the Fetal MembraneChowdhury TT, Barrett DW and David AL
In Fetal Therapy, Cambridge University Press (Cup) 520-531.
21-10-2019
Targeting mechanotransduction
mechanisms and tissue weakening
signals in the human amniotic
membraneBARRETT DW, John RK, Thrasivoulou C, MATA A, Deprest JA, Becker DL, David AL and CHOWDHURY TINA
Scientific Reports, Nature Publishing Group
30-04-2019
2018
Corrigendum for Engels, Joyeux, Van der Merwe, et al. (2017) DOI: 10.1002/pd.5191Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Pranpanus S, Barrett DW, Connon C, Chowdhury TT, David AL and Deprest J
Prenatal Diagnosis, Wiley vol. 38 (6), 471-471.
01-05-2018
2017
Tissuepatch is biocompatible and seals iatrogenic membrane defects in a rabbit model.Engels AC, Joyeux L, Van der Merwe J, Jimenez J, Prapanus S, Barrett DW, Connon C, Chowdhury TT, David AL and Deprest J
Prenatal Diagnosis, Wiley vol. 38 (2), 99-105.
25-11-2017
Trauma induces overexpression of Cx43 in human fetal membrane defectsBarrett DW, Kethees A, Thrasivoulou C, Mata A, Virasami A, Sebire NJ, Engels AC, Deprest JA, Becker DL, David AL and Chowdhury TT
Prenatal Diagnosis vol. 37 (9), 899-906.
01-09-2017
2016
Connexin 43 is overexpressed in human fetal membrane defects after fetoscopic surgeryBarrett DW, David AL, Thrasivoulou C, Mata A, Becker DL, Engels AC, Deprest JA and Chowdhury TT
Prenatal Diagnosis vol. 36 (10), 942-952.
01-10-2016
Oxygen tension modulates the effects of TNFα in compressed chondrocytes.Tilwani RK, Vessillier S, Pingguan-Murphy B, Lee DA, Bader DL and Chowdhury TT
Inflamm Res
22-09-2016
2015
Imaging modalities for the in vivo surveillance of mesenchymal stromal cells.Hossain MA, Chowdhury T and Bagul A
J Tissue Eng Regen Med vol. 9 (11), 1217-1224.
01-11-2015
C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytesPeake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ and Chowdhury TT
Biochemical and Biophysical Research Communications, Elsevier vol. 465 (4), 784-789.
22-08-2015
Polyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damagePeake N, Pavlov A, D'Souza A, Alfasahin I, Pingaan-Murphy B, Sukhurukov G, Hobbs A and Chowdhury T
Osteoarthritis and Cartilage, Elsevier vol. 23, a141-a142.
01-04-2015
Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants.Peake NJ, Pavlov AM, D'Souza A, Pingguan-Murphy B, Sukhorukov GB, Hobbs AJ and CHOWDHURY TT
Biomacromolecules, American Chemical Society
04-01-2015
2014
Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function.Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and Chowdhury TT
Osteoarthritis Cartilage vol. 22 (11), 1800-1807.
01-11-2014
Tensile strain increased COX-2 expression and PGE2 release leading to weakening of the human amniotic membraneChowdhury B, David AL, Thrasivoulou C, Becker DL, Bader DL and Chowdhury TT
Placenta, Elsevier vol. 35 (12), 1057-1064.
19-09-2014
Role of C-type natriuretic peptide signaling in maintaining cartilage and bone function.Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and CHOWDHURY TT
Osteoarthritis and Cartilage, Elsevier/Science Direct vol. online edition
30-07-2014
Imaging modalities for the in vivo surveillance of mesenchymal stromal cellsHossain MA, CHOWDHURY TT and Bagul A
Journal of Tissue Engineering and Regenerative Medicine, Wiley
11-06-2014
PFM.37 Cyclic tensile strain increases PGE2 release leading to weakening of the human term amniotic membraneChowdhury B, David A, Bader D, Thrasivoulou C, Becker D and Chowdhury T
Archives of Disease in Childhood Fetal & Neonatal, Bmj vol. 99 (Suppl 1)
01-06-2014
α5β1 integrin mediates compression-induced inhibition of catabolic effects induced by fibronectin fragments in an oxygen-dependent mannerParker E, Vessillier S, Abas WW, Bader DL, Pinguaan-Murphy B and Chowdhury TT
Osteoarthritis and Cartilage, Elsevier vol. 22
01-04-2014
2013
Low oxygen tension increased FN-f induced catabolic activities - response prevented with biomechanical signalsParker E, Vessillier S, Pinguaan-Murphy B, Wan Abas WAB, Bader DL and Chowdhury TT
Arthritis Research and Therapy, Biomed Central vol. 15 (5), R163-R163.
25-10-2013
Optimisation of quantitative real-time PCR studies in cartilage mechanobiologyAkanji O, Salter DM and Chowdhury TT
In Pcr Technology. Current Innovations, Crc Pressi Llc, Editors: Nolan T and Bustin SA. 271-281.
03-06-2013
FN-f induced catabolic activities are dependent on oxygen tension in chondrocyte/agarose constructs subjected to biomechanical signalsParker E, Pinguuan-Murphy B, Bader DL and Chowdhury TT
Osteoarthritis and Cartilage, Elsevier vol. 21
01-04-2013
Biological vascular grafts for hemodialysis access.Hossain MA, Frampton AE, Chowdhury TT and Morsey M
Expert Rev Med Devices, Informa Healthcare vol. 2 (10), 171-175.
01-03-2013
Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor modelPeake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ and Chowdhury TT
Arthritis Research and Therapy, Bio Med Central vol. 15 (4)
01-01-2013
Optimization of Quantitative Real-Time PCR for Studies in Cartilage MechanobiologyAkanji O, Salter D and Chowdhury T
In Pcr Technology: Current Innovations, Third Edition 271-281.
01-01-2013
2012
Biomechanical conditioning enhanced matrix synthesis in nucleus pulposus cells cultured in agarase constructs with TGFβCHOWDHURY TT, Tilwani RK and Bader DL
, Editors: Goldsmith EC and Lin SK. Journal Functional Biomaterials vol. 3, 23-26.
05-01-2012
2011
Biomechanical signals and the C-type natriuretic peptide counteract catabolic activities induced by IL-1β in chondrocyte/agarose constructsRamachandran M, Achan P, Salter DM, Bader DL and Chowdhury TT
Arthritis Research and Therapy vol. 13 (5)
13-09-2011
Biomechanical influence of cartilage homeostasis in health and disease.Bader DL, Salter DM and Chowdhury TT
Arthritis vol. 2011
01-01-2011
Quantification of mRNA using real-time PCR and Western blot analysis of MAPK events in chondrocyte/agarose constructs.Lee DA, Brand J, Salter D, Akanji O-O and Chowdhury TT
Methods Mol Biol vol. 695, 77-97.
01-01-2011
2010
Biomechanical modulation of collagen fragment-induced anabolic and catabolic activities in chondrocyte/agarose constructsChowdhury TT, Schulz RM, Rai SS, Thuemmler CB, Wuestneck N, Bader A and Homandberg GA
Arthritis Research and Therapy vol. 12 (3)
12-05-2010
Mechanical loading modulates chondrocyte primary cilia incidence and lengthMcGlashan SR, Knight MM, Chowdhury TT, Joshi P, Jensen CG, Kennedy S and Poole CA
Cell Biology International vol. 34 (5), 441-446.
01-01-2010
Dynamic compression alters NFκB activation and IκB-α expression in IL-1β-stimulated chondrocyte/agarose constructsAkanji OO, Sakthithasan P, Salter DM and Chowdhury TT
Inflammation Research vol. 59 (1), 41-52.
01-01-2010
2009
458 DYNAMIC COMPRESSION ALTERS NF?B ACTIVATION AND I?B-α EXPRESSION IN IL-1β STIMULATED CHONDROCYTE/AGAROSE CONSTRUCTSAkanji OO, Salter DM and Chowdhury TT
Osteoarthritis and Cartilage, Elsevier vol. 17, s245-s246.
01-09-2009
Dynamic compression inhibits fibronectin fragment induced iNOS and COX-2 expression in chondrocyte/agarose constructsRaveenthiran SP and Chowdhury TT
Biomechanics and Modeling in Mechanobiology vol. 8 (4), 273-283.
01-01-2009
2008
451 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN-FRAGMENT INDUCED INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTSRaveenthiran SP and Chowdhury TT
Osteoarthritis and Cartilage, Elsevier vol. 16, s195-s196.
01-09-2008
Signal transduction pathways involving p38 MAPK, JNK, NF kappa B and AP-1 influences the response of chondrocytes cultured in agarose constructs to IL-1 beta and dynamic compressionChowdhury TT, Salter DM, Bader DL and Lee DA
Inflamm Res vol. 57 (7), 306-313.
01-07-2008
Dynamic compression influences IL-1β induced NO and PGE2 release, via alterations in iNOS and COX-2 activityCHOWDHURY TT, Akanjii OO, Salter DM and Lee DA
In 5th International Symposium On Mechanobiology of Cartilage and Chondrocyte, Editors: Stoltz JF. 689-754.
01-01-2008
Dynamic compression counteracts IL-1beta induced inducible nitric oxide synthase and cyclo-oxygenase-2 expression in chondrocyte/agarose constructs.Chowdhury TT, Arghandawi S, Brand J, Akanji OO, Bader DL, Salter DM and Lee DA
Arthritis Res Ther vol. 10 (2)
01-01-2008
Dynamic compression influences interleukin-1 beta-induced nitric oxide and prostaglandin E-2 release by articular chondrocytes via alterations in iNOS and COX-2 expressionChowdhury TT, Akanji OO, Salter DM, Bader DL and Lee DA
Biorheology vol. 45 (3-4), 257-274.
01-01-2008
2007
52 REAL-TIME PCR USING MOLECULAR BEACONS TO DETECT INOS AND COX-2 EXPRESSION IN CHONDROCYTE/AGAROSE CONSTRUCTS SUBJECTED TO IL-1β AND DYNAMIC COMPRESSIONChowdhury TT, Akanji OO, Arghandawi S, Salter DM, Bader DL and Lee DA
Osteoarthritis and Cartilage, Elsevier vol. 15, c42-c43.
01-12-2007
Loading alters actin dynamics and up-regulates cofilin gene expression in chondrocytesCampbell JJ, Blain EJ, Chowdhury TT and Knight MM
Biochemical and Biophysical Research Communications vol. 361 (2), 329-334.
21-09-2007
2006
Purinergic pathway suppresses the release of NO and stimulates proteoglycan synthesis in chondrocyte/agarose constructs subjected to dynamic compressionChowdhury TT and Knight MM
Journal of Cellular Physiology vol. 209 (3), 845-853.
01-12-2006
Integrin-mediated mechanotransduction in IL-1 beta stimulated chondrocytes.Chowdhury TT, Appleby RN, Salter DM, Bader DA and Lee DA
Biomech Model Mechanobiol vol. 5 (2-3), 192-201.
01-06-2006
Anti-inflammatory effects of IL-4 and dynamic compression in IL-1beta stimulated chondrocytes.Chowdhury TT, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 339 (1), 241-247.
06-01-2006
Dynamic compression counteracts IL-1β induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructsCHOWDHURY TT, Bader DL and Lee DA
In Mechanobiology: Cartilage and Chondrocyte, Ios Press, Editors: Stoltz JF. 413-429.
01-01-2006
Dynamic compression counteracts IL-1beta induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructs.Chowdhury TT, Bader DL and Lee DA
Biorheology vol. 43 (3,4), 413-429.
01-01-2006
P140 DYNAMIC COMPRESSION COUNTERACTS FIBRONECTIN FRAGMENT INDUCED UPREGULATION OF NITRIC OXIDEChowdhury TT, Raveenthiran SP, Bader DL and Lee DA
Osteoarthritis and Cartilage, Elsevier vol. 14
01-01-2006
2005
Dynamic compression counteracts IL-1-induced iNOS and COX-2 activity by human chondrocytes cultured in agarose constructsChowdhury TT, Bader DL and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 251-252.
01-12-2005
Integrin mediated mechanotransduction in IL-1 stimulated bovine chondrocytes cultured in agarose constructsChowdhury TT, Appleby RN, Salter DA, Bader DL and Lee DA
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 545-546.
01-12-2005
Dynamic compression counteracts IL-1β induced INOS and COX-2 activity by human chondrocytes cultured in agarose constructsChowdhury TT, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2)
01-07-2005
Dynamic compression influences the biochemical response of human mesenchymal stem cells cultured in agarose constructsCatuogno C, Chowdhury TT, Bader DL and Lee DA
European Cells and Materials vol. 10 (SUPPL.2)
01-07-2005
British Society for Matrix Biology Autumn Meeting Joint with the UK Tissue & Cell Engineering Society, University of Bristol, UKInternational Journal of Experimental Pathology, Wiley vol. 86 (3), a1-a56.
24-05-2005
2004
Integrin-mediated mechanotransduction processes in TGFbeta-stimulated monolayer-expanded chondrocytes.Chowdhury TT, Salter DM, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 318 (4), 873-881.
11-06-2004
Crosslinking density influences chondrocyte metabolism in dynamically loaded photocrosslinked poly(ethylene glycol) hydrogels.Bryant SJ, Chowdhury TT, Lee DA, Bader DL and Anseth KS
Ann Biomed Eng vol. 32 (3), 407-417.
01-03-2004
2003
Temporal regulation of chondrocyte metabolism in agarose constructs subjected to dynamic compression.Chowdhury TT, Bader DL, Shelton JC and Lee DA
Arch Biochem Biophys vol. 417 (1), 105-111.
01-09-2003
Dynamic compression counteracts IL-1 beta-induced release of nitric oxide and PGE2 by superficial zone chondrocytes cultured in agarose constructs.Chowdhury TT, Bader DL and Lee DA
Osteoarthritis Cartilage vol. 11 (9), 688-696.
01-09-2003
Control of mechanotrasduction processes in dynamically stimulated human and bovine chondrocytes cultured in agarose constructs.Chowdhury TT, Shelton JC, Bader DL and LEE DA
Internat. J. Artificial Organs vol. 26 (9), 858-858.
01-01-2003
alpha5beta1 integrin mediates mechanotransduction processes in TGFbeta-stimulated human chondrocyte / agarose constructs and subjected to dynamic compression.Chowdhury TT, LEE DA, Salter DM, Shelton JC and Bader DL
Osteoarthritis Cartilage vol. 11 (Suppl 1), S2-S3.
01-01-2003
2001
Dynamic compression inhibits the synthesis of nitric oxide and PGE(2) by IL-1beta-stimulated chondrocytes cultured in agarose constructs.Chowdhury TT, Bader DL and Lee DA
Biochem Biophys Res Commun vol. 285 (5), 1168-1174.
03-08-2001
2000
Dynamic compression inhibits the synthesis of nitric oxide by IL-1β stimulated chondrocytes cultured in agarose constructsChowdhury TT, Bader DL and Lee DA
Second Smith and Nephew International Symposium - Tissue Engineering 2000: Advances in Tissue Engineering, Biomaterials and Cell
01-12-2000
Grants
Grants of specific relevance to Predictive in vitro ModelsMechanisms underlying preterm birth in women with HIV in rural ZimbabweAndrew Prendergast, Ruairi Robertson, Melanie Smuk, Claire Bourke, Nikolaos Donos, Robert Allaker, Abish Stephen, Conrad Bessant, Stefaan Verbruggen and Tina Chowdhury
£1,142,315 MRC Medical Research Council
01-05-2024 - 30-04-2027
Extreme heat and preterm birth in rural ZimbabweAndrew Prendergast, Andrew Russell, Melanie Smuk, Tina Chowdhury and Stamatina Iliodromiti
£460,148 Wellcome Trust
01-10-2023 - 30-09-2028
Tommy’s National Preterm Birth Research CentreStamatina Iliodromiti, Tina Chowdhury and Steven Thornton
£432,791 Tommy's
01-04-2023 - 31-03-2028
Engineering the fetal membranesTina Chowdhury
£40,000 Prenatal Charity UCL EGA INSTITUTE FOR WOMEN’S HEALTH
01-12-2018 - 01-10-2028