Dr Timothy Hopkins
Versus Arthritis Research Fellow
Research
Osteoarthritis, Cartilage, Synovium, Organ-on-a-Chip
Interests
I am currently working on a Versus Arthritis funded Foundation Fellowship within SEMS. The aim of the fellowship is to develop an organ-on-a-chip model of human cartilage and synovium ‘joint-on-a-chip’ to understand how these tissues interact in the human knee in health and disease. We believe that this interaction plays a key role in the pathobiology of osteoarthritis and influences how individual patients respond to treatment. We are seeking to improve our understanding in these key areas and ultimately to use the joint-on-a-chip to stratify and personalise therapies for osteoarthritis.Publications
2025
Increased synovitis and pro-inflammatory macrophage abundance are observed in the synovia of patients at risk of developing post-traumatic OA compared to those with established OAHopkins T, Garcia J, Hulme CH, Tins B, Perry J, Jermin P, Gallacher P, Barnett A et al.
Osteoarthritis and Cartilage Open, Elsevier Bv vol. 7 (3), 100643-100643.
01-09-2025
Engineering growth factor gradients to drive spatiotemporal tissue patterning in organ-on-a-chip systemsHopkins T, Midha S, Grossemy S, Screen HRC, Wann AKT, Knight MM
Journal of Tissue Engineering, Sage Publications vol. 16
18-04-2025
2024
Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine ModelPerry J, Mennan C, Cool P, McCarthy HS, Newell K, Hopkins T, Hulme C, Wright KT et al.
Cartilage, Sage Publications
03-11-2024
2023
Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitmentThompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT, Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6)
10-10-2023
Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the KneeHopkins T, Roberts S, Richardson JB, Gallacher P, Bailey A, Kuiper JH
Orthopaedic Journal of Sports Medicine, Sage Publications vol. 11 (2)
01-02-2023
2022
Chondrocyte Isolation and ExpansionHarrison P, Hopkins T, Hulme C, McCarthy H, Wright K
In Methods in Molecular Biology, Springer Us 9-19.
11-11-2022
2021
Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi StudyHopkins T, Richardson J, Kuiper JH
Surgeries, Mdpi Ag vol. 2 (3), 286-302.
06-08-2021
An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in HumansHopkins T, Wright KT, Kuiper NJ, Roberts S, Jermin P, Gallacher P, Kuiper JH
Cells, Mdpi Ag vol. 10 (8), 1903-1903.
27-07-2021
Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation ModelMarkides H, Foster NC, McLaren JS, Hopkins T, Black C, Oreffo ROC, Scammell BE, Echevarria I et al.
Cells, Mdpi Ag vol. 10 (7), 1776-1776.
14-07-2021
2020
The use of technology in the subcategorisation of osteoarthritis: a Delphi study approachMennan C, Hopkins T, Channon A, Elliott M, Johnstone B, Kadir T, Loughlin J, Peffers M et al.
Osteoarthritis and Cartilage Open, Elsevier Bv vol. 2 (3), 100081-100081.
01-09-2020
2019
Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man CasesWang J, Wright KT, Perry J, Tins B, Hopkins T, Hulme C, McCarthy HS, Brown A et al.
Cell Transplantation, Sage Publications vol. 28 (7), 924-931.
08-05-2019
Grants
Grants of specific relevance to Predictive in vitro ModelsMicro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicinesMartin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council
Grant Summary
01-10-2024 - 30-09-2027
Human synovium-cartilage organ-chip for personalised surgical screeningMartin Knight and Timothy Hopkins
£311,203 Versus Arthritis
01-04-2022 - 30-06-2026
Organ-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacementHazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research
Grant Summary
07-10-2024 - 14-03-2025