Dr Timothy Hopkins
Versus Arthritis Research Fellow
Research
Osteoarthritis, Cartilage, Synovium, Organ-on-a-Chip
Interests
I am currently working on a Versus Arthritis funded Foundation Fellowship within SEMS. The aim of the fellowship is to develop an organ-on-a-chip model of human cartilage and synovium ‘joint-on-a-chip’ to understand how these tissues interact in the human knee in health and disease. We believe that this interaction plays a key role in the pathobiology of osteoarthritis and influences how individual patients respond to treatment. We are seeking to improve our understanding in these key areas and ultimately to use the joint-on-a-chip to stratify and personalise therapies for osteoarthritis.Publications
Publications of specific relevance to Predictive in vitro Models2024
Perry J, Mennan C, Cool P, McCarthy HS, Newell K, Hopkins T, Hulme C, Wright KT, Henson FMD and Roberts S (2024). Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model. Cartilage 2023
Thompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM (2023). Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment. IOP Publishing Biomedical Materials vol. 18, (6) Hopkins T, Roberts S, Richardson JB, Gallacher P, Bailey A and Kuiper JH (2023). Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the Knee. SAGE Publications Orthopaedic Journal of Sports Medicine vol. 11, (2) 2022
Harrison P, Hopkins T, Hulme C, McCarthy H and Wright K (2022). Chondrocyte Isolation and Expansion. Cartilage Tissue Engineering , Editors: Stoddart MJ, Della Bella E and Armiento AR. Springer Nature 2021
Hopkins T, Richardson J and Kuiper JH (2021). Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi Study. MDPI Surgeries vol. 2, (3) 286-302. Hopkins T, Wright KT, Kuiper NJ, Roberts S, Jermin P, Gallacher P and Kuiper JH (2021). An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in Humans. MDPI Cells vol. 10, (8) Markides H, Foster NC, McLaren JS, Hopkins T, Black C, Oreffo ROC, Scammell BE, Echevarria I, White LJ and Haj AJE (2021). Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation Model. MDPI Cells vol. 10, (7) 2020
Mennan C, Hopkins T, Channon A, Elliott M, Johnstone B, Kadir T, Loughlin J, Peffers M, Pitsillides A, Sofat N, Stewart C, Watt FE, Zeggini E, Holt C, Roberts S and Consortium TON (2020). The use of technology in the subcategorisation of osteoarthritis: a Delphi study approach. Elsevier Osteoarthritis and Cartilage Open vol. 2, (3) 2019
Wang J, Wright KT, Perry J, Tins B, Hopkins T, Hulme C, McCarthy HS, Brown A and Richardson JB (2019). Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man Cases. SAGE Publications Cell Transplantation vol. 28, (7) 924-931. Grants
Grants of specific relevance to Predictive in vitro ModelsOrgan-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacementHazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (07-10-2024 - 14-03-2025)
APP13387: Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicinesMartin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council (01-07-2024 - 30-06-2027)