Dr Timothy Hopkins
Versus Arthritis Research Fellow
Research
Osteoarthritis, Cartilage, Synovium, Organ-on-a-Chip
Interests
I am currently working on a Versus Arthritis funded Foundation Fellowship within SEMS. The aim of the fellowship is to develop an organ-on-a-chip model of human cartilage and synovium ‘joint-on-a-chip’ to understand how these tissues interact in the human knee in health and disease. We believe that this interaction plays a key role in the pathobiology of osteoarthritis and influences how individual patients respond to treatment. We are seeking to improve our understanding in these key areas and ultimately to use the joint-on-a-chip to stratify and personalise therapies for osteoarthritis.Publications
Publications of specific relevance to Predictive in vitro Models2024
Intra-Articular Injection of Human Umbilical Cord-Derived Mesenchymal Stromal Cells Reduces Radiographic Osteoarthritis in an Ovine Model.Perry J, Mennan C, Cool P, McCarthy HS, Newell K, Hopkins T, Hulme C, Wright KT, Henson FMD and Roberts S
Cartilage, Sage Publications (Immediate Access)
03-11-2024
2023
Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitmentThompson CL, Hopkins T, Bevan C, Screen HRC, Wright KT and Knight MM
Biomedical Materials, Iop Publishing vol. 18 (6)
10-10-2023
Relationship Between Activity Level and Knee Function Is Influenced by Negative Affect in Patients Undergoing Cell Therapy for Articular Cartilage Defects in the KneeHopkins T, Roberts S, Richardson JB, Gallacher P, Bailey A and Kuiper JH
Orthopaedic Journal of Sports Medicine, Sage Publications vol. 11 (2)
01-02-2023
2022
Chondrocyte Isolation and ExpansionHarrison P, Hopkins T, Hulme C, McCarthy H and Wright K
In Cartilage Tissue Engineering, Springer Nature, Editors: Stoddart MJ, Della Bella E and Armiento AR.
11-11-2022
2021
Identifying Consensus and Open Questions around Assessing or Predicting the Quality and Success of Cartilage Repair: A Delphi StudyHopkins T, Richardson J and Kuiper JH
Surgeries, Mdpi vol. 2 (3), 286-302.
06-08-2021
An In Vitro System to Study the Effect of Subchondral Bone Health on Articular Cartilage Repair in HumansHopkins T, Wright KT, Kuiper NJ, Roberts S, Jermin P, Gallacher P and Kuiper JH
Cells, Mdpi vol. 10 (8)
27-07-2021
Short-Term Evaluation of Cellular Fate in an Ovine Bone Formation ModelMarkides H, Foster NC, McLaren JS, Hopkins T, Black C, Oreffo ROC, Scammell BE, Echevarria I, White LJ and Haj AJE
Cells, Mdpi vol. 10 (7)
14-07-2021
2020
The use of technology in the subcategorisation of osteoarthritis: a Delphi study approachMennan C, Hopkins T, Channon A, Elliott M, Johnstone B, Kadir T, Loughlin J, Peffers M, Pitsillides A, Sofat N, Stewart C, Watt FE, Zeggini E, Holt C, Roberts S and Consortium TON
Osteoarthritis and Cartilage Open, Elsevier vol. 2 (3)
09-06-2020
2019
Combined Autologous Chondrocyte and Bone Marrow Mesenchymal Stromal Cell Implantation in the Knee: An 8-year Follow Up of Two First-In-Man CasesWang J, Wright KT, Perry J, Tins B, Hopkins T, Hulme C, McCarthy HS, Brown A and Richardson JB
Cell Transplantation, Sage Publications vol. 28 (7), 924-931.
08-05-2019
Grants
Grants of specific relevance to Predictive in vitro ModelsOrgan-chip Facility: A world-class in vitro models facility for the UK community, reducing the barriers to adoption to drive animal replacementHazel Screen, Stefaan Verbruggen, Martin Knight, Julia Shelton, Timothy Hopkins and John Connelly
£573,537 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
Grant Summary
07-10-2024 - 14-03-2025
Micro-manufacturing of tissue patterned organ-chips for accelerated deployment of new medicinesMartin Knight, Hazel Screen, Julien Gautrot, Timothy Hopkins, John Connelly, Liisa Blowes and Xavier Griffin
£1,787,725 EPSRC Engineering and Physical Sciences Research Council
Grant Summary
01-10-2024 - 30-09-2027