Dr Vahitha Abdul Salam
Lecturer
Centre for Cardiovascular Medicine and Device Innovation
Queen Mary University of London
Queen Mary University of London
Research
Vascular dysfunction, Proteomics, Drug Discovery, Chloride intracellular channel protein, Pulmonary hypertension, Environmental Toxicology
Interests
My research involves using multidisciplinary approaches to discover and develop drugs that affect vascular health. For example, I am currently developing inhibitors of chloride intracellular channel proteins as a target for cardiovascular diseases and cancer. In addition, I plan to establish vasculature-on-chip models to validate such inhibitors' use and study the interaction of environmental toxicants on vascular health.Publications
2023
Intracellular Chloride Channels Regulate Endothelial Metabolic Reprogramming in Pulmonary Arterial Hypertension.Alzaydi MM, Abdul-Salam VB, Whitwell HJ, Russomanno G, Glynos A, Capece D, Szabadkai G, Wilkins MR and Wojciak-Stothard B
American Journal of Respiratory Cell and Molecular Biology, American Thoracic Society vol. 68 (1), 103-115.
01-01-2023
2022
Structure-based discovery and in vitro validation of inhibitors of chloride intracellular channel 4 proteinOlotu F, Medina-Carmona E, Serrano-Sanchez A, Ossa F, El-Hamdaoui A, Bishop ÖT, Ortega-Roldan JL and Abdul-Salam VB
Computational and Structural Biotechnology Journal, Elsevier vol. 21, 688-701.
24-12-2022
A Zn2+-triggered two-step mechanism of CLIC1 membrane insertion and activation into chloride channelsVarela L, Hendry AC, Cassar J, Martin-Escolano R, Cantoni D, Ossa F, Edwards JC, Abdul-Salam V and Ortega-Roldan JL
Journal of Cell Science, The Company of Biologists vol. 135 (15)
01-08-2022
2021
Comorbidities and Risk Factors for Severe Outcomes in COVID-19 Patients in Saudi Arabia: A Retrospective Cohort StudyShaikh FS, Aldhafferi N, Buker A, Alqahtani A, Dey S, Abdulhamid S, AlBuhairi DAM, Alkabour RSA, Atiyah WSO, Chrouf SB, Alshehri A, Olatunji SO, Almuhaideb AM, Alshahrani MS, AlMunsour Y and Abdul-Salam VB
Journal of Multidisciplinary Healthcare, Taylor & Francis vol. 14, 2169-2183.
01-08-2021
Nanoscale Study of Calcium Handling Remodeling in Right Ventricular Cardiomyocytes Following Pulmonary Hypertension.Medvedev R, Sanchez-Alonso JL, Alvarez-Laviada A, Rossi S, Dries E, Schorn T, Abdul-Salam VB, Trayanova N, Wojciak-Stothard B, Miragoli M, Faggian G and Gorelik J
Hypertension vol. 77 (2), 605-616.
01-02-2021
2020
miR-150-PTPMT1-cardiolipin signaling in pulmonary arterial hypertensionRussomanno G, Jo KB, Abdul-Salam VB, Morgan C, Endruschat J, Schaeper U, Osman AH, Alzaydi MM, Wilkins MR and Wojciak-Stothard B
Molecular Therapy - Nucleic Acids, Elsevier vol. 23, 142-153.
04-11-2020
Author Correction: Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertension.Sindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Bogaard HJ, Morgan CC, Pullamsetti SS, Alzaydi MM, Rhodes CJ, Piva R, Eichstaedt CA, Grünig E, Wilkins MR and Wojciak-Stothard B
Nat Commun vol. 11 (1), 3300-3300.
30-06-2020
1 Role of endothelial microRNA-150 in pulmonary arterial hypertensionRussomanno G, Jo KB, Abdul Salam V, Morgan C, Alzaydi M, Wilkins M and Wojciak-Stothard B
Biorxiv
25-03-2020
Therapeutic potential of KLF2-induced exosomal microRNAs in pulmonary hypertensionSindi HA, Russomanno G, Satta S, Abdul-Salam VB, Jo KB, Qazi-Chaudhry B, Ainscough AJ, Szulcek R, Jan Bogaard H, Morgan CC, Pullamsetti SS, Alzaydi MM, Rhodes CJ, Piva R, Eichstaedt CA, Grünig E, Wilkins MR and Wojciak-Stothard B
Nature Communications, Springer Nature vol. 11 (1)
04-03-2020
2018
CLIC4/Arf6 Pathway A New Lead in BMPRII Inhibition in Pulmonary HypertensionAbdul-Salam VB, Russomanno G, Chien-Nien C, Mahomed AS, Yates LA, Wilkins MR, Zhao L, Gierula M, Dubois O, Schaeper U, Endruschat J and Wojciak-Stothard B
Circ Res vol. 124 (1), 52-65.
15-10-2018
Proteomic analysis at the sites of clinical infection with invasive Streptococcus pyogenesEdwards RJ, Pyzio M, Gierula M, Turner CE, Abdul-Salam VB and Sriskandan S
Scientific Reports, Springer Nature vol. 8 (1)
13-04-2018
2017
Tipifarnib prevents development of hypoxia-induced pulmonary hypertensionDuluc L, Ahmetaj-Shala B, Mitchell J, Abdul-Salam VB, Mahomed AS, Aldabbous L, Oliver E, Iannone L, Dubois OD, Storck EM, Tate EW, Zhao L, Wilkins MR and Wojciak-Stothard B
Cardiovascular Research, Oxford University Press (Oup) vol. 113 (3), 276-287.
05-01-2017
2016
Neutrophil Extracellular Traps Promote AngiogenesisAldabbous L, Abdul-Salam V, McKinnon T, Duluc L, Pepke-Zaba J, Southwood M, Ainscough AJ, Hadinnapola C, Wilkins MR, Toshner M and Wojciak-Stothard B
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 36 (10), 2078-2087.
28-07-2016
2014
Aberrant Chloride Intracellular Channel 4 Expression Contributes to Endothelial Dysfunction in Pulmonary Arterial HypertensionWojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR, Edwards JC, Yuspa SH, Howard LS, Edwards RJ, Rhodes CJ, Gibbs JSR, Wharton J, Zhao L and Wilkins MR
Circulation, Wolters Kluwer vol. 129 (17), 1770-1780.
06-02-2014
2010
Proteomic Analysis of Lung Tissues From Patients With Pulmonary Arterial HypertensionAbdul-Salam VB, Wharton J, Cupitt J, Berryman M, Edwards RJ and Wilkins MR
Circulation, Wolters Kluwer vol. 122 (20), 2058-2067.
01-11-2010
Investigation of lactate dehydrogenase isoenzymes as candidate biomarkers of idiopathic pulmonary arterial hypertensionParatz E and Abdul Salam V
Australian Medical Student Journal vol. 1, 16-20.
22-04-2010
Identification and Assessment of Plasma Lysozyme as a Putative Biomarker of AtherosclerosisAbdul-Salam VB, Ramrakha P, Krishnan U, Owen DR, Shalhoub J, Davies AH, Tang TY, Gillard JH, Boyle JJ, Wilkins MR and Edwards RJ
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 30 (5), 1027-1033.
18-02-2010
2006
Identification of plasma protein biomarkers associated with idiopathic pulmonary arterial hypertensionAbdul‐Salam VB, Paul GA, Ali JO, Gibbs SR, Rahman D, Taylor GW, Wilkins MR and Edwards RJ
Proteomics, Wiley vol. 6 (7), 2286-2294.
22-03-2006
Grants
KTP with WRc: Risk Assessment of Microplastics in Human Health (PI: Vahitha Abdul Salam)Vahitha Abdul Salam and Kate Spencer
£216,984 Innovate UK
01-08-2023 - 31-07-2025
KTP Capacity Building Competition 2022Akram Alomainy, Greg Slabaugh, Alastair Noyce, Vahitha Abdul Salam and Viji Draviam Sastry
£34,544 Innovate UK
01-12-2022 - 31-03-2023
Water Research Centre Pump Priming AwardVahitha Abdul Salam
£20,000 Water Research Centre
01-04-2022 - 31-03-2023