Prof Wen Wang

Wen Wang

Vice-Principal and Executive Dean

School of Engineering and Materials Science
Queen Mary University of London

Research

Cardiovascular Models

Interests

My work focuses on vascular bioengineering and biomaterial mechanics, including studies on the endothelial glycocalyx, vascular stem cells and progenator cells, transmembrane and transcapillary exchange. We are interested in developing in vitro models to study fundamental vascular mechanobiology and involvement in disease.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Delivery of small interfering RNA by hydrogen sulfide-releasing nanomotor for the treatment of Parkinson's disease
Wang W, Zhao Z, Zhang Z, Wu Z, Zhang Y, Wang K, Dai M, Mao C and Wan M
Journal of Controlled Release, Elsevier vol. 377, 648-660.  
30-11-2024
Microfluidic SERS biosensor based on Au-semicoated photonic crystals for melanoma diagnosis
Wang W, Mao W, Sun H, Hou F, Wang W, Liu W, Shi Z, Lin G, Wang M, Fang G, Cheng YY and Xu C
Biosensors and Bioelectronics, Elsevier vol. 271 
29-11-2024
An unexpected role of IL10 in mesoderm induction and differentiation from pluripotent stem cells: Implications in zebrafish angiogenic sprouting, vascular organoid development, and therapeutic angiogenesis
Niu K, Zhang C, Liu C, Wu W, Yan Y, Zheng A, Liu S, Shi Z, Yang M, Wang W and Xiao Q
European Journal of Cell Biology, Elsevier vol. 103 (4) 
24-10-2024
Droplets can enhance microcapsule deformation in channel flow
Jing D, Lu R, Farutin A, Guo Z, Wang F, Wang W, Misbah C and Sui Y
Communications Physics, Springer Nature vol. 7 (1) 
20-09-2024
A Self‐Assembled 3D Model Demonstrates How Stiffness Educates Tumor Cell Phenotypes and Therapy Resistance in Pancreatic Cancer
Liu Y, Okesola BO, de la Peña DO, Li W, Lin M, Trabulo S, Tatari M, Lawlor RT, Scarpa A, Wang W, Knight M, Loessner D, Heeschen C, Mata A and Pearce OMT
Advanced Healthcare Materials, Wiley vol. 13 (17) 
22-03-2024
Highly sensitive SERS platform for pathogen analysis by cyclic DNA nanostructure@AuNP tags and cascade primer exchange reaction
Xiao Y, Luo S, Qiu J, Zhang Y, Liu W, Zhao Y, Zhu Y, Deng Y, Lu M, Liu S, Lin Y, Huang A, Wang W, Hu X and Gu B
Journal of Nanobiotechnology, Springer Nature vol. 22 (1) 
26-02-2024

2023

A sensitive and rapid electrochemical biosensor for sEV-miRNA detection based on domino-type localized catalytic hairpin assembly
Li W, Wang W, Luo S, Chen S, Ji T, Li N, Pan W, Zhang X, Wang X, Li K, Zhang Y and Yan X
Journal of Nanobiotechnology, Springer Nature vol. 21 (1) 
09-09-2023
Core–Shell-Structured Electrorheological Fluid with a Polarizability-Tunable Nanocarbon Shell for Enhanced Stimuli-Responsive Activity
Chen S, Cheng Y, Zhao Z, Zhang K, Hao T, Sui Y, Wang W, Zhao J and Li Y
Acs Applied Materials & Interfaces, American Chemical Society (Acs) vol. 15 (29), 35741-35749.  
14-07-2023
Rapid and efficient fluorescent aptasensor for PD-L1 positive extracellular vesicles isolation and analysis: EV-ANCHOR
Feng J, Jia L, Pan W, Fan Y, Guo J, Luo T, Liu C, Wang W, Zheng L and Li B
Chemical Engineering Journal, Elsevier vol. 465 
01-06-2023
A method for real-time mechanical characterisation of microcapsules
Guo Z, Lin T, Jing D, Wang W and Sui Y
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 22 (4), 1209-1220.  
24-03-2023
A computational model for the transit of a cancer cell through a constricted microchannel
Wang Z, Lu R, Wang W, Tian FB, Feng JJ and Sui Y
Biomechanics and Modeling in Mechanobiology, Springer Nature vol. 22 (4), 1129-1143.  
28-02-2023
A simple and sensitive electrochemical biosensor for circulating tumor cell determination based on dual-toehold accelerated catalytic hairpin assembly
Zhang X, Jiang X, Wang W, Luo S, Guan S, Li W, Situ B, Li B, Zhang Y and Zheng L
Microchimica Acta, Springer Nature vol. 190 (2) 
24-01-2023

2022

Localized DNA tetrahedrons assisted catalytic hairpin assembly for the rapid and sensitive profiling of small extracellular vesicle-associated microRNAs
Zhang Y, Li W, Ji T, Luo S, Qiu J, Situ B, Li B, Zhang X, Zhang T, Wang W, Xiao Y, Zheng L and Yan X
Journal of Nanobiotechnology, Springer Nature vol. 20 (1) 
01-12-2022
[Retracted] Diagnostic Value of IGFBP‐2 in Predicting Preeclampsia before 20 Weeks of Pregnancy: A Prospective Nested Case‐Control Study
Gao F, Yin J, Long Y, Zhu S, Huang Z, Wang J, Zheng H, Wang W and Zheng L
Computational and Mathematical Methods in Medicine, Hindawi vol. 2022 (1) 
28-09-2022
Extracellular Vesicles of Mesenchymal Stem Cells Are More Effectively Accessed through Polyethylene Glycol‐Based Precipitation than by Ultracentrifugation
Jia L, Li B, Fang C, Liang X, Xie Y, Sun X, Wang W, Zheng L and Wang D
Stem Cells International, Hindawi vol. 2022 (1) 
06-09-2022
Disinfector-Assisted Low Temperature Reduced Graphene Oxide-Protein Surgical Dressing for the Postoperative Photothermal Treatment of Melanoma
Wu Y, Yang J, van Teijlingen A, Berardo A, Corridori I, Feng J, Xu J, Titirici MM, Rodriguez-Cabello JC, Pugno NM, Sun J, Wang W, Tuttle T and Mata A
Advanced Functional Materials 
08-07-2022
Investigating the Fibrillar Ultrastructure and Mechanics in Keloid Scars Using In Situ Synchrotron X-ray Nanomechanical Imaging.
Zhang Y, Hollis D, Ross R, Snow T, Terrill NJ, Lu Y, Wang W, Connelly J, Tozzi G and Gupta HS
Materials (Basel), Mdpi vol. 15 (5) 
01-03-2022
Characterising Mechanical Properties of Flowing Microcapsules Using a Deep Convolutional Neural Network
T. Lin TL, Z. Wang ZW, R. X. Lu RXL, W. Wang WW and Y. Sui YS
Advances in Applied Mathematics and Mechanics, Global Science Press vol. 14 (1), 79-100.  
01-01-2022

2021

The role of actomyosin in the regulation of syndecan-1 in hyperosmosis
Li W and Wang W
Bba - General Subjects, Elsevier vol. 1865 (10) 
31-07-2021
Path selection of a train of spherical capsules in a branched microchannel
Lu RX, Wang Z, Salsac A-V, Barthès-Biesel D, Wang W and Sui Y
Journal of Fluid Mechanics, Cambridge University Press (Cup) vol. 923 
22-07-2021
Growth and self-jumping of single condensed droplet on nanostructured surfaces: A molecular dynamics simulation
Pu JH, Wang SK, Sun J, Wang W and Wang HS
Journal of Molecular Liquids, Elsevier vol. 340, 116902-116902.  
02-07-2021
Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion.
Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS
Acs Applied Materials and Interfaces, American Chemical Society vol. 13 (22), 25792-25804.  
26-05-2021
An interfacial self-assembling bioink for the manufacturing of capillary-like structures with tuneable and anisotropic permeability.
Wu Y, Fortunato GM, Okesola BO, Brocchetti FLPD, Suntornnond R, Connelly J, De Maria C, Rodriguez-Cabello JC, Vozzi G, Wang W and Mata A
Biofabrication, Iop Publishing vol. 13 (3) 
08-04-2021
Stable and Efficient Nanofilm Pure Evaporation on Nanopillar Surfaces
Pu JH, Wang SK, Sun J, Wang W and Wang HS
Langmuir vol. 37 (12), 3731-3739.  
08-03-2021
The Identification of Plasma Exosomal miR-423-3p as a Potential Predictive Biomarker for Prostate Cancer Castration-Resistance Development by Plasma Exosomal miRNA Sequencing
Guo T, Wang Y, Jia J, Mao X, Stankiewicz E, Scandura G, Burke E, Xu L, Marzec J, Davies CR, Lu JJ, Rajan P, Grey A, Tipples K, Hines J, Kudahetti S, Oliver T, Powles T, Alifrangis C, Kohli M, Shaw G, Wang W, Feng N, Shamash J, Berney D, Wang L and Lu Y-J
Frontiers in Cell and Developmental Biology, Frontiers vol. 8 
07-01-2021
Activation of TRPV4 by mechanical, osmotic or pharmaceutical stimulation is anti-inflammatory blocking IL-1β mediated articular cartilage matrix destruction
Fu S, Meng H, Inamdar S, Das B, Gupta H, Wang W, Thompson C and Knight M
, Editors: Block JA. Osteoarthritis and Cartilage, Elsevier 
01-01-2021
A high-throughput method to characterize membrane viscosity of flowing microcapsules
Lin T, Wang Z, Lu R, Wang W and Sui Y
Physics of Fluids, Aip Publishing vol. 33 (1) 
01-01-2021
A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules
Lin T, Wang Z, Wang W and Sui Y
Soft Matter, Royal Society of Chemistry (Rsc) vol. 17 (15), 4027-4039.  
01-01-2021
Correction: A neural network-based algorithm for high-throughput characterisation of viscoelastic properties of flowing microcapsules
Lin T, Wang Z, Wang W and Sui Y
Soft Matter, Royal Society of Chemistry (Rsc) vol. 17 (15), 4213-4213.  
01-01-2021
Molecular Dynamics Simulation of Effect of Temperature Difference on Surface Condensation
Pu JH, Sheng Q, Sun J, Wang W and Wang HS
In Advances in Heat Transfer and Thermal Engineering, Springer Nature 99-103.  
01-01-2021

2020

miR-214-3p-Sufu-GLI1 is a novel regulatory axis controlling inflammatory smooth muscle cell differentiation from stem cells and neointimal hyperplasia
He S, Yang F, Yang M, An W, Maguire EM, Chen Q, Xiao R, Wu W, Zhang L, Wang W and Xiao Q
Stem Cell Research & Therapy, Springer Nature vol. 11 (1) 
03-11-2020
Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices
Wu Y, Wang W, Mata A, Pugno N, Azevedo H, Karabasov S and Titirici M-M
Nature Communications, Nature Research (Part of Springer Nature) 
04-03-2020
Generation and Evolution of Nanobubbles on Heated Nanoparticles: A Molecular Dynamics Study
Pu JH, Sun J, Wang W and Wang HS
Langmuir: The Acs Journal of Surfaces and Colloids, American Chemical Society vol. 36, 2375-2382.  
03-02-2020
A histone deacetylase 7-derived peptide promotes vascular regeneration via facilitating 14-3-3γ phosphorylation
Yang J, Moraga A, Xu J, Zhao Y, Luo P, Lao KH, Margariti A, Zhao Q, Ding W, Wang G, Zhang M, Zheng L, Zhang Z, Hu Y, Wang W, Shen L, Smith A, Shah AM, Wang Q and Zeng L
Stem Cells, Oxford University Press (Oup) vol. 38 (4), 556-573.  
29-01-2020
Problematic Internet Use, Non-Medical Use of Prescription Drugs, and Depressive Symptoms among Adolescents: A Large-Scale Study in China
Fan B, Wang W, Wang T, Xie B, Zhang H, Liao Y, Lu C and Guo L
International Journal of Environmental Research and Public Health, Mdpi vol. 17 (3) 
26-01-2020

2019

Dependences of Formation and Transition of the Surface Condensation Mode on Wettability and Temperature Difference.
Pu JH, Sun J, Sheng Q, Wang W and Wang HS
Langmuir: The Acs Journal of Surfaces and Colloids, American Chemical Society vol. 36, 456-464.  
15-12-2019
Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo
Arokiasamy S, King R, Boulaghrasse H, Poston R, Nourshargh S, Wang W and Voisin M-B
Frontiers in Immunology, Frontiers Media 
04-10-2019
Membrane tension regulates syndecan-1 expression through actin remodelling.
Li W and Wang W
Biochim Biophys Acta Gen Subj vol. 1863 (11), 129413-129413.  
08-08-2019
Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces.
Pang X, Li W, Landwehr E, Yuan Y, Wang W and Azevedo HS
Faraday Discuss 
15-07-2019
Mechanical loading inhibits cartilage inflammatory signalling via an HDAC6 and IFT-dependent mechanism regulating primary cilia elongation
Fu S, Thompson CL, Ali A, Wang W, Chapple JP, Mitchison HM, Beales PL, Wann AKT and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 27 (7), 1064-1074.  
25-03-2019
Dependence of nano-confined surface condensation on tangentially external force field
PU JH, SHENG Q, Sun J, WANG W and WANG H
Journal of Molecular Liquids, Elsevier 
21-03-2019
A fate-alternating transitional regime in contracting liquid filaments
Wang F, Contò FP, Naz N, Castrejón-Pita JR, Castrejón-Pita AA, Bailey CG, Wang W, Feng JJ and Sui Y
Journal of Fluid Mechanics vol. 860, 640-653.  
10-02-2019
Biofluids: Microcirculation
Lu Y and Wang W
In Comprehensive Biotechnology 32-46.  
01-01-2019
Path Selection of a Spherical Capsule in a Branched Channel
Wang Z, Sui Y, Wang W, Barthѐs-Biesel D and Salsac A-V
Molecular & Cellular Biomechanics, Tech Science Press vol. 16 (S2), 42-43.  
01-01-2019

2018

Serum Cystatin C Levels in Twin Pregnancy versus Singleton Pregnancy
Peng J, Wang W, Zheng L, Guan Y, Ye G, Tong H, Wang Y and Wang Q
Lab Medicine, Oxford University Press (Oup) vol. 50 (2), 163-167.  
04-12-2018
Surface-Initiated Poly(oligo(2-alkyl-2-oxazoline)methacrylate) Brushes.
Tang P, di Cio S, Wang W and E Gautrot J
Langmuir vol. 34 (34), 10019-10027.  
28-08-2018
Bayes’ theorem based binary algorithm for fast reference-less calibration of a multimode fiber
ZHAO T, DENG L, WANG W, Elson D and SU L
Optics Express, Optical Society of America (Osa) 
06-08-2018
Path selection of a spherical capsule in a microfluidic branched channel: Towards the design of an enrichment device
Wang Z, Sui Y, Salsac AV, Barthès-Biesel D and Wang W
Journal of Fluid Mechanics vol. 849, 136-162.  
18-06-2018
Bifunctional aptamer-mediated catalytic hairpin assembly for the sensitive and homogenous detection of rare cancer cells.
Liu J, Zhang Y, Zhao Q, Situ B, Zhao J, Luo S, Li B, Yan X, Vadgama P, Su L, Ma W, Wang W and Zheng L
Anal Chim Acta vol. 1029, 58-64.  
04-05-2018
The interaction between XBP1 and eNOS contributes to endothelial cell migration
Yang J, Xu J, Danniel M, Wang X, Wang W, Zeng L and Shen L
Experimental Cell Research, Elsevier vol. 363 (2), 262-270.  
17-01-2018
Hsa_Circ_0001275: A Potential Novel Diagnostic Biomarker for Postmenopausal Osteoporosis
Zhao K, Zhao Q, Guo Z, Chen Z, Hu Y, Su J, Chen L, He Z, Cai X, Chen M, Zheng L, Wang W and Wang Q
Cellular Physiology and Biochemistry, Karger Publishers vol. 46 (6), 2508-2516.  
01-01-2018

2017

How solid surface free energy determines coalescence-induced nanodroplet jumping: A molecular dynamics investigation
SHENG Q, SUN J, WANG W, WANG HS and BAILEY CG
Journal of Applied Physics, Aip Publishing vol. 122, 245301 (2017) 
27-12-2017
Degradation and biocompatibility of photoembossed PLGA-acrylate blend for improved cell adhesion.
Hughes-Brittain NF, Qiu L, Wang W, Peijs T and Bastiaansen CWM
J Biomed Mater Res B Appl Biomater vol. 106 (1), 163-171.  
08-12-2017
118A novel method to determine left atrial compliance in vivo: relationship with markers of remodelling in AF
Norton R, Honarbakshs S, Wang W, Schilling R and Hunter R
Ep Europace, Oxford University Press (Oup) vol. 19 (suppl_1), i49-i49.  
01-10-2017
Effects of High Pressure on Phospholipid Bilayers
WANG W
Journal of Physical Chemistry B, American Chemical Society 
19-09-2017
Structural alteration of the endothelial glycocalyx: contribution of the actin cytoskeleton.
Li W and Wang W
Biomech Model Mechanobiol 
14-08-2017
Surface texturing of electrospun fibres by photoembossing using pulsed laser interference holography and its effects on endothelial cell adhesion
Hughes-Brittain NF, Qiu L, Picot OT, Wang W, Peijs T and Bastiaansen CWM
Polymer (United Kingdom) vol. 125, 40-49.  
26-07-2017
A Cytokine-Like Protein Dickkopf-Related Protein 3 Is Atheroprotective.
Yu B, Kiechl S, Qi D, Wang X, Song Y, Weger S, Mayr A, Le Bras A, Karamariti E, Zhang Z, Barco Barrantes ID, Niehrs C, Schett G, Hu Y, Wang W, Willeit J, Qu A and Xu Q
Circulation vol. 136 (11), 1022-1036.  
03-07-2017
Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation
VOISIN M
Scientific Reports, Nature Publishing Group 
13-03-2017

2016

Responses of Vascular Endothelial Cells to Photoembossed Topographies on Poly(Methyl Methacrylate) Films.
Qiu L, Hughes-Brittain NF, Bastiaansen CWM, Peijs T and Wang W
J Funct Biomater vol. 7 (4) 
09-12-2016
Motion of a spherical capsule in branched tube flow with finite inertia
Wang Z, Sui Y, Salsac AV, Barthès-Biesel D and Wang W
Journal of Fluid Mechanics vol. 806, 603-626.  
13-10-2016
Interfibrillar stiffening of echinoderm mutable collagenous tissue demonstrated at the nanoscale.
Mo J, Prévost SF, Blowes LM, Egertová M, Terrill NJ, Wang W, Elphick MR and Gupta HS
Proc Natl Acad Sci U S A 
05-10-2016
On the onset of surface condensation: Formation and transition mechanisms of condensation mode
Sheng Q, Sun J, Wang Q, Wang W and Wang HS
Scientific Reports, Nature Publishing Group: Open Access Journals - Option C 
02-08-2016
Vascular Stem/Progenitor Cell Migration Induced by Smooth Muscle Cell-Derived Chemokine (C-C Motif) Ligand 2 and Chemokine (C-X-C motif) Ligand 1 Contributes to Neointima Formation
Yu B, Wong MM, Potter CMF, Simpson RML, Karamariti E, Zhang Z, Zeng L, Warren D, Hu Y, Wang W and Xu Q
Stem Cells, Wiley vol. 34 (9), 2368-2380.  
28-06-2016
A target-triggered dual amplification strategy for sensitive detection of microRNA
Lv W, Zhao J, Situ B, Li B, Ma W, Liu J, Wu Z, Wang W, Yan X and Zheng L
Biosensors and Bioelectronics 
19-04-2016
IFT88 influences chondrocyte actin organization and biomechanics
KNIGHT MM, wang W, wang Z, wann A, thompson C and hassen A
Osteoarthritis and Cartilage 
01-03-2016

2015

Electrochemical determination of microRNAs based on isothermal strand-displacement polymerase reaction coupled with multienzyme functionalized magnetic micro-carriers
Ma W, Situ B, Lv W, Li B, Yin X, Vadgama P, Zheng L and Wang W
Biosensors and Bioelectronics vol. 80, 344-351.  
21-12-2015
Effects of Lipid Composition on Bilayer Membranes Quantified by All-Atom Molecular Dynamics
Ding W, Palaiokostas M, Wang W and Orsi M
The Journal of Physical Chemistry B, American Chemical Society (Acs) vol. 119 (49), 15263-15274.  
24-11-2015
XBP 1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling
Zeng L, Li Y, Yang J, Wang G, Margariti A, Xiao Q, Zampetaki A, Yin X, Mayr M, Mori K, Wang W, Hu Y and Xu Q
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (10), 2134-2144.  
27-08-2015
Upregulated sirtuin 1 by miRNA-34a is required for smooth muscle cell differentiation from pluripotent stem cells
Yu X, Zhang L, Wen G, Zhao H, Luong LA, Chen Q, Huang Y, Zhu J, Ye S, Xu Q, Wang W and Xiao Q
Cell Death and Differentiation vol. 22 (7), 1170-1180.  
01-07-2015
Dickkopf Homolog 3 Induces Stem Cell Differentiation into Smooth Muscle Lineage via ATF6 Signalling*
Wang X, Karamariti E, Simpson R, Wang W and Xu Q
Journal of Biological Chemistry, Elsevier vol. 290 (32), 19844-19852.  
23-06-2015
Abstract 662: X-box Binding Protein 1 Splicing Promotes Wound Healing via Modulating Endothelial Nitric Oxide Synthase
Yang J, Zeng L, Wang W and Li Y
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (suppl_1) 
01-05-2015
Abstract 200: Vascular Stem Cell Migration in Response to Monocyte Chemoattractant Protein-1 Promotes Neointima Lesion Formation
Yu B, Wong MM, Wang W, Hu Y and Xu Q
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (suppl_1) 
01-05-2015
Abstract 9: Smooth Muscle Cells Are Crucial for Vascular Stem Cell Migration and Vasculogenesis via Keratinocyte Cell-derived Chemokine
Yu B, Wong MM, Potter C, Hu Y, Wang W and Xu Q
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 35 (suppl_1) 
01-05-2015
Histone deacetylases and cardiovascular cell lineage commitment.
Yang J-Y, Wang Q, Wang W and Zeng L-F
World Journal of Stem Cells, Baishideng Publishing Group vol. 7 (5), 852-858.  
01-01-2015

2014

Microcapsules functionalized with neuraminidase can enter vascular endothelial cells in vitro.
Liu W, Wang X, Bai K, Lin M, Sukhorukov G and Wang W
J R Soc Interface vol. 11 (101) 
06-12-2014
The rate of hypo-osmotic challenge influences regulatory volume decrease (RVD) and mechanical properties of articular chondrocytes
Wang Z, Irianto J, Kazun S, Wang W and Knight MM
Osteoarthritis and Cartilage, Elsevier vol. 23 (2), 289-299.  
11-11-2014
Biofunctionalization of PEGylated microcapsules for exclusive binding to protein substrates.
Deo DI, Gautrot JE, Sukhorukov GB and Wang W
Biomacromolecules vol. 15 (7), 2555-2562.  
14-07-2014
Viscous dissipation effect in nano-confined shear flows: a comparative study between molecular dynamics and multi-scale hybrid simulations
Sun J, Wang W and Wang HS
Microfluidics and Nanofluidics, Springer Link 
01-05-2014
Photoembossing of surface relief structures in polymer films for biomedical applications.
Hughes-Brittain NF, Qiu L, Wang W, Peijs T and Bastiaansen CWM
J Biomed Mater Res B Appl Biomater vol. 102 (2), 214-220.  
01-02-2014
Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro
Bai K and Wang W
Biomechanics and Modeling in Mechanobiology vol. 13 (2), 303-311.  
01-01-2014
Converging Parallel Plate Flow Chambers for Studies on the Effect of the Spatial Gradient of Wall Shear Stress on Endothelial Cells
Lu$y.lu@derby.ac.uk$School of Engineering and Technology Y, University of Derby , Derby , Science UW-QLSOEAM, Mary , University of London , London , Oraifige$School of Engineering and Technology UI and Science UWWSOEAM
Journal of Biosciences and Medicines, Scientific Research Publishing vol. 02 (02), 50-56.  
01-01-2014

2013

Three-dimensional dynamics of oblate and prolate capsules in shear flow
Wang Z, Sui Y, Spelt PDM and Wang W
Physical Review E: Statistical, Nonlinear, and Soft Matter Physics, American Physical Society vol. 88 
26-11-2013
Histone deacetylase 3 unconventional splicing mediates endothelial-to-mesenchymal transition through transforming growth factor β2.
Zeng L, Wang G, Ummarino D, Margariti A, Xu Q, Xiao Q, Wang W, Zhang Z, Yin X, Mayr M, Cockerill G, Li JY-S, Chien S, Hu Y and Xu Q
J Biol Chem vol. 288 (44), 31853-31866.  
01-11-2013
MicroRNA-200C and -150 play an important role in endothelial cell differentiation and vasculogenesis by targeting transcription repressor ZEB1.
Luo Z, Wen G, Wang G, Pu X, Ye S, Xu Q, Wang W and Xiao Q
Stem Cells vol. 31 (9), 1749-1762.  
01-09-2013
Numerical simulation of the hydrodynamics of endothelial glycocalyx under shear flow
Ye S, Wang W and Shao X
Ieee International Conference On Control and Automation, Icca, 923-928.  
26-08-2013
Abstract 004: Microrna-22 Regulates Smooth Muscle Cell Differentiation From Stem Cells By Targeting Methyl Cpg Binding Protein 2
Zhao H, Huang Y, Yu X, Wen G, Wang W, Ye S and Xiao Q
Circulation Research, Wolters Kluwer vol. 113 (suppl_1) 
01-08-2013
Vascular endothelial cell growth-activated XBP1 splicing in endothelial cells is crucial for angiogenesis
Zeng L, Xiao Q, Chen M, Margariti A, Martin D, Ivetic A, Xu H, Mason J, Wang W, Cockerill G, Mori K, Yi-Shuan Li J, Chien S, Hu Y and Xu Q
Circulation vol. 127 (16), 1712-1722.  
23-04-2013
XBP1 mRNA splicing triggers an autophagic response in endothelial cells through BECLIN-1 transcriptional activation
Margariti A, Li H, Chen T, Martin D, Vizcay-Barrena G, Alam S, Karamariti E, Xiao Q, Zampetaki A, Zhang Z, Wang W, Jiang Z, Gao C, Ma B, Chen YG, Cockerill G, Hu Y, Xu Q and Zeng L
Journal of Biological Chemistry vol. 288 (2), 859-872.  
11-01-2013
Dependence of nanoconfined liquid behavior on boundary and bulk factors
Sun J, Wang W and Wang HS
Physical Review E: Statistical, Nonlinear, and Soft Matter Physics vol. 87 
01-01-2013
Dependence between velocity slip and temperature jump in shear flows
Sun J, Wang W and Wang HS
The Journal of Chemical Physics, American Institute of Physics vol. 138 (23) 
01-01-2013
Shear stress-induced redistribution of the glycocalyx on endothelial cells in vitro
Bai K and Wang W
Biomechanics and Modeling in Mechanobiology, 1-9.  
01-01-2013

2012

Spatio-temporal development of the endothelial glycocalyx layer and its mechanical property in vitro
Bai K and Wang W
Journal of The Royal Society Interface vol. 9 (74), 2290-2298.  
07-09-2012
Inert gas clearance from tissue by co-currently and counter-currently arranged microvessels.
Lu Y, Michel CC and Wang W
J Appl Physiol (1985) vol. 113 (3), 487-497.  
01-08-2012
Contribution of stem cells to neointimal formation of decellularized vessel grafts in a novel mouse model
Tsai TN, Kirton JP, Campagnolo P, Zhang L, Xiao Q, Zhang Z, Wang W, Hu Y and Xu Q
American Journal of Pathology vol. 181 (1), 362-373.  
01-07-2012
Left atrial wall stress distribution and its relationship to electrophysiologic remodeling in persistent atrial fibrillation
Hunter RJ, Liu Y, Lu Y, Wang W and Schilling RJ
Circulation: Arrhythmia and Electrophysiology vol. 5 (2), 351-360.  
01-04-2012
Gap junction permeability between tenocytes within tendon fascicles is suppressed by tensile loading
Maeda E, Ye S, Wang W, Bader DL, Knight MM and Lee DA
Biomechanics and Modeling in Mechanobiology vol. 11 (3-4), 439-447.  
01-01-2012
Microrna-200c and-150 Play a Role in Human Embryonic Stem Cell Differentiation Into Endothelial Cells and Blood Vessel Formation by Targeting Transcription Repressor Zebi
Luo Z, Wen G, Wang G, Pu X, Wang W, Ye S, Xu Q and Xiao Q
Circulation vol. 126 (21) 
01-01-2012

2011

DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TOWARDS THE ENDOTHELIAL LINEAGE INVOLVES MICRORNAS
Luo Z, Xiao Q, Wang W and Xu Q
Heart vol. 97 (20), 4-4.  
01-10-2011
Biofluids
Lu Y and Wang W
In Comprehensive Biotechnology, Second Edition 237-250.  
09-09-2011
Simulated Microgravity, Erythroid Differentiation, and the Expression of Transcription Factor GATA-1 in CD34(+) Cells
Zheng L, Liu JZ, Hu YW, Zhong TY, Xiong SL, Wang W and Wang Q
Aviat Space Envir Md vol. 82 (5), 513-517.  
01-05-2011
Taylor dispersion in finite-length capillaries
Vikhansky A and Wang W
Chem Eng Sci vol. 66 (4), 642-649.  
15-02-2011
Inbuilt mechanisms for overcoming functional problems inherent in hepatic microlobular structure.
Cohen RD, Brown CL, Nickols C, Levey P, Boucher BJ, Greenwald SE and Wang W
Comput Math Methods Med vol. 2011 
01-01-2011
Signalling pathways that regulate endothelial differentiation from stem cells
Luo ZL, Wang G, Wang W, Xiao QZ and Xu QB
Front Biosci-Landmrk vol. 16, 472-485.  
01-01-2011
5.19 Biofluids | Microcirculation
Lu Y and Wang W
In Comprehensive Biotechnology, Elsevier 237-250.  
01-01-2011
5.03 Biofluids: Microcirculation
Lu Y and Wang W
In Comprehensive Biotechnology, Elsevier 32-46.  
01-01-2011

2010

Endothelium oriented differentiation of bone marrow mesenchymal stem cells under chemical and mechanical stimulations
Bai K, Huang Y, Jia X, Fan Y and Wang W
Journal of Biomechanics vol. 43 (6), 1176-1181.  
01-04-2010
Multiscale modeling of fluid and solute transport in soft tissues and microvessels
Lu Y and Wang W
Journal of Multiscale Modeling vol. 2 (1-2), 127-145.  
01-03-2010
A compartment model to evaluate the permeability of gap junctions between tenocytes in tendon fascicles
Ye S, Maeda E, Knight M, Lee D, Bader D and Wang W
Faseb Journal vol. 24 
01-01-2010
1P338 1J1450 Mechano-regulation of gap junction communications between tenocytes within isolated fascicles(Bioengineering,Oral Presentations,The 48th Annual Meeting of the Biophysical Society of Japan)
Maeda E, Ye S, Knight M, Wang W, Bader D and Lee D
Seibutsu Butsuri, Biophysical Society of Japan vol. 50 (supplement2) 
01-01-2010

2009

Growth factors enhance endothelial progenitor cell proliferation under high-glucose conditions
Li W, Yang SYY, Hu ZF, Winslet MC, Wang W and Seifalian AM
Med Sci Monitor vol. 15 (12), BR357-BR363.  
01-12-2009
Osteogenic differentiation of human mesenchymal stem cells within a perfused bioreactor system
Campbell JJ, Maeda E, Ye SJ, Wang W and Lee DA
European Cells and Materials vol. 18 (SUPPL. 2) 
01-07-2009
Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow
Zeng L, Zampetaki A, Margariti A, Pepe AE, Alam S, Martin D, Xiao Q, Wang W, Jin ZG, Cockerill G, Mori K, Li YSJ, Hu Y, Chien S and Xu Q
Proceedings of The National Academy of Sciences of The United States of America vol. 106 (20), 8326-8331.  
19-05-2009
Dynamic responses of shear flows over a deformable porous surface layer in a cylindrical tube
Wen PH, Hon YC and Wang W
Appl Math Model vol. 33 (1), 423-436.  
01-01-2009

2008

Rheological effects of blood in a nonplanar distal end-to-side anastomosis
Wang QQ, Ping BH, Xu QB and Wang W
Journal of Biomechanical Engineering vol. 130 (5) 
01-10-2008
Interaction between the interstitial fluid and the extracellular matrix in confined indentation
Lu Y and Wang W
Journal of Biomechanical Engineering vol. 130 (4) 
01-08-2008
Interaction between micro-particles in Oseen flows by the method of fundamental solutions
Wang W and Wen PH
Eng Anal Bound Elem vol. 32 (4), 318-327.  
01-04-2008

2007

Change in properties of the glycocalyx affects the shear rate and stress distribution on endothelial cells
Wang W
J Biomech Eng-T Asme vol. 129 (3), 324-329.  
01-06-2007
Movement of a spherical cell in capillaries using a boundary element method
Wen PH, Aliabadi MH and Wang W
J Biomech vol. 40 (8), 1786-1793.  
01-01-2007

2006

Proteomic analysis reveals higher demand for antioxidant protection in embryonic stem cell-derived smooth muscle cells
Yin XK, Mayr M, Xiao QZ, Wang W and Xu QB
Proteomics vol. 6 (24), 6437-6446.  
01-12-2006
Characterization of a laminar flow cell for the prevention of biosensor fouling
Kyriacou G, Vadgama P and Wang W
Med Eng Phys vol. 28 (10), 989-998.  
01-12-2006
Laminar flow of micropolar fluid in rectangular microchannels
Ye SJ, Zhu KQ and Wang W
Acta Mech Sinica vol. 22 (5), 403-408.  
01-10-2006
Indices of electromyographic activity and the slow component of oxygen uptake kinetics during high-intensity knee-extension exercise in humans
Garland SW, Wang W and Ward SA
Eur J Appl Physiol vol. 97 (4), 413-423.  
01-07-2006
Effects of osmotic pressure in the extracellular matrix on tissue deformation
Lu Y, Parker KH and Wang W
Philos T R Soc A vol. 364 (1843), 1407-1422.  
15-06-2006
Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses.
Chen J, Lu X-Y and Wang W
J Biomech vol. 39 (11), 1983-1995.  
01-01-2006
Non-Newtonian effects of blood flow on hemodynamics in distal vascular graft anastomoses
Chen J, Lu XY and Wang W
J Biomech vol. 39 (11), 1983-1995.  
01-01-2006

2005

Modelling the concentration polarisation of hyaluronan on the surface of the synovial lining of infused joints
Lu Y, Levick JR and Wang W
Proceedings of The 2005 Summer Bioengineering Conference vol. 2005, 824-825.  
01-12-2005
Microelectrodes and biocompatible sensors for skin pO2 measurements
Wang W and Vadgama P
, 337-352.  
01-12-2005
The mechanism of synovial fluid retention in pressurized joint cavities
Lu Y, Levick JR and Wang W
Microcirculation vol. 12 (7), 581-595.  
01-10-2005
In vivo measurements and theoretical modelling of oxygen partial pressure in outer layers of human skin
Wang W
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Effects of cyclic loads on transport of fluid and solutes in cell seeded constructs
Lu Y and Wang W
European Cells and Materials vol. 10 (SUPPL.2) 
01-07-2005
Oxygen partial pressure in outer layers of skin: Simulation using three-dimensional multilayered models
Wang W
Microcirculation vol. 12 (2), 195-207.  
01-03-2005
Proteomic dataset of Sca-1+ progenitor cells
WANG W, Yin XK, Xu QB, Wait R, Mayr U, Mayr M, Xiao QZ and Tarelli E
Proteomics vol. 5 (17), 4533-4545.  
01-01-2005

2004

Concentration polarization of hyaluronan on the surface of the synovial lining of infused joints
Lu Y, Levick JR and Wang W
J Physiol-London vol. 561 (2), 559-573.  
01-12-2004
O-2 microsensors for minimally invasive tissue monitoring
Wang W and Vadgama P
J Roy Soc Interface vol. 1 (1), 109-117.  
22-11-2004
Numerical Analysis of the non-Newtonian blood flow in the non-planar artery with bifurcation
WANG W, Zhuang LX, Chen J and Lu XY
Journal of Hydrodynamics, B 
01-01-2004
Solute transport in porous medium under external loads
Lu Y and Wang W
Proceedings of The Asme Heat Transfer/Fluids Engineering Summer Conference 2004, Ht/Fed 2004 vol. 4, 693-699.  
01-01-2004
Concentration polarisation of hyaluronan on the surface of the synovial lining of infused joints
WANG W, Lu Y and Levick JR
Journal of Physiology 
01-01-2004
O2 microsensors for minimally invasive tissue monitoring
VADGAMA PM and Wang W
J.R. Soc. Interface vol. 1, 109-117.  
01-01-2004
Interaction between fluid and solid i extracellular matrix
Bader DL, WANG W, Lu Y, Li ZY and Parker KH
Recent Advances in Fluid Mechanics, 679-682.  
01-01-2004

2003

Oxygen partial pressure in outer layers of skin of human finger nail folds
Wang W, Winlove CP and Michel CC
J Physiol-London vol. 549 (3), 855-863.  
15-06-2003

2002

A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin
Chen W, Lu XY, Zhuang LX and Wang W
Chinese Journal of Biomedical Engineering vol. 21 (6), 481-492.  
20-12-2002
Parallel-plate flow chamber for studies of 3D flow-endothelium interaction
Watkins NV, Caro CG and Wang W
Biorheology vol. 39 (3-4), 337-342.  
01-01-2002
Breaking symmetry in non-planar bifurcations: Distribution of flow and wall shear stress
Lu YL, Lu XY, Zhuang LX and Wang W
Biorheology vol. 39 (3-4), 431-436.  
01-01-2002
Breaking symmetry in a non-planar bifurcations: distribution of flow and wall shear stress
WANG W, Lu YL, Zhuang LX and Lu XY
Biorheology vol. 39, 431-436.  
01-01-2002
A numerical study on oxygen transport by cutaneous microcirculation in outer layers of skin
WANG W, Lu XY, Chen W and Zhuang LX
Journal of Biomedical Engineering vol. 21 (6), 216-228.  
01-01-2002

2001

Distribution of oxygen partial pressure in dermal papillae of human finger nailfolds
WANG W, Michel CC and Winlove CP
Journal of Vascular Research vol. 38 (4), 398-412.  
01-01-2001
exchange mechanism between microvessels and interstitium in the renal medulla
WANG W
Recent Advances in Biomechanics, 248-262.  
01-01-2001
Parallel-plate flow chamber for studies of 3D flow-endothelium interaction
WANG W, Caro CG, Watkins NV and Gao ZX
Journal of Physiology vol. 531P, 14-14.  
01-01-2001

2000

Modeling exchange of plasma proteins between microcirculation and interstitium of the renal medulla
Wang W and Michel CC
Am J Physiol-Renal vol. 279 (2), F334-F344.  
01-08-2000
A critical parameter for transcapillary exchange of small solutes in countercurrent systems
Wang W
J Biomech vol. 33 (5), 543-548.  
01-05-2000
Clearance of plasma proteins from the renal medulla
Wang W and Michel CC
Faseb J vol. 14 (4), A23-A23.  
15-03-2000

1999

A three-dimensional model on PO2 distribution in outer layers of human skin
Wang W, Michel CC and Winlove CP
J Vasc Res vol. 36 (4), 333-333.  
01-07-1999
Modelling PO2 distribution in outer layers of skin
Wang W, Michel CC and Winlove CP
Faseb J vol. 13 (4), A25-A25.  
12-03-1999

1998

Movement of spherical particles in capillaries using a boundary singularity method
Wang W and Parker KH
J Biomech vol. 31 (4), 347-354.  
01-04-1998

1997

Effects of anastomoses on salute transcapillary exchange in countercurrent systems
Wang W and Michel CC
Microcirculation-London vol. 4 (3), 381-390.  
01-01-1997

1996

CFD studies of separation of mists from gases using vane-type separators
Wang W and Davies GA
Chemical Engineering Research & Design vol. 74 (A2), 232-238.  
01-01-1996

1995

A SIMPLIFIED MATHEMATICAL-MODEL FOR THE TRANSCAPILLARY EXCHANGE OF FLUID AND ALBUMIN IN THE RENAL MEDULLA
WANG W and MICHEL CC
J Physiol-London vol. 483P, P139-P139.  
01-02-1995
THE EFFECT OF DEFORMABLE POROUS SURFACE-LAYERS ON THE MOTION OF A SPHERE IN A NARROW CYLINDRICAL TUBE
WANG W and PARKER KH
J Fluid Mech vol. 283, 287-305.  
25-01-1995
A theoretical study of transient cross-flow filtration using force balance analysis
Wang W, Jia X and Davies GA
The Chemical Engineering Journal and The Biochemical Engineering Journal vol. 60 (1-3), 55-62.  
01-01-1995

1994

A MODEL FOR FLOW-THROUGH DISCONTINUITIES IN THE TIGHT JUNCTION OF THE ENDOTHELIAL INTERCELLULAR CLEFT
PHILLIPS CG, PARKER KH and WANG W
B Math Biol vol. 56 (4), 723-741.  
01-07-1994

1993

PATHWAYS THROUGH THE INTERCELLULAR CLEFTS OF FROG MESENTERIC CAPILLARIES
ADAMSON RH, MICHEL CC, PARKER KH, PHILLIPS CG and WANG W
J Physiol-London vol. 466, 303-327.  
01-07-1993

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconEPSRC Core Equipment 2024
Wen Wang, Kshitij Sabnis, Andrei Sapelkin, Joseph Briscoe and Ian Sanders
£449,082 EPSRC Engineering and Physical Sciences Research Council
01-01-2025 - 30-06-2026
solid heart iconEpithelial Exchange Surfaces – From organizing principles to novel culture models of the gatekeepers of the body
Martin Knight, Hazel Screen, Wen Wang, Clare Thompson and Cleo Bishop
£260,676 EPSRC - EU Scheme 
Grant Summary

01-12-2023 - 30-11-2027

bullet iconEPSRC Core Equipment Award 2022
Wen Wang, Isabelle Mareschal, Massimo Poesio and Michael Reece
£875,000 EPSRC Engineering and Physical Sciences Research Council
03-01-2023 - 02-07-2024
bullet iconEPSRC Core Equipment 2020
Wen Wang, Ketao Zhang, Matteo Palma and Ildar Farkhatdinov
£497,496 EPSRC Engineering and Physical Sciences Research Council
01-11-2020 - 30-04-2022
bullet iconNewton International Fellowship 2019: Dynamics of microcapsules in inertial two-phase flows-Dalei Jing
Wen Wang and Yi Sui
£103,316 Royal Society
01-03-2020 - 28-02-2022
bullet iconEPSRC Core Equipment Call
Wen Wang, Martin Knight, Clive Parini and Isaac Abrahams
£125,000 EPSRC Engineering and Physical Sciences Research Council
13-02-2020 - 12-08-2021
bullet iconPhD stipend and consumables for Mr S Feng
Wen Wang
£100,000 Zhoukou Tianjiukang Pharmaceutical Co. Ltd
01-01-2019 - 31-12-2022
bullet iconNPIF Doctoral Training Grant
Wen Wang
£34,664 EPSRC Engineering and Physical Sciences Research Council
01-10-2018 - 31-03-2020
bullet iconIndustrial PhD Award
Wen Wang
£100,000 Jinan Yucaoxuan Biotechnology Co. Ltd
01-09-2018 - 31-08-2022
bullet iconPhD Scholarship: Miss Xinqing Pang
Wen Wang
£60,000 ShijiazHuiran Software Technology
01-10-2017 - 30-09-2021
bullet iconPhD Scholarship: Mr Yuezhou Zhang
Wen Wang
£49,500 Wuxi Second Hospital
01-10-2017 - 30-09-2020
bullet iconPhD Scholarship in Complex Networks
Wen Wang
£80,000 Shenzhen Aoxinke Electronics Ltd
01-09-2016 - 30-09-2020
bullet iconPhD Scholarship in Vascular Bioengineering
Wen Wang
£60,000 Ju-Nail Technology Co Ltd
01-12-2015 - 30-11-2019
bullet iconMSMART
Wen Wang
£127,046 EU Commission - Horizon 2020
01-09-2015 - 31-08-2018