Dr Yung-Yao Lin
Senior Lecturer
Centre for Genomics and Child Health, Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Human induced pluripotent stem cells, CRISPR genome editing, Neuromuscular disorders, Disease modelling, Regenerative medicine, Tissue engineering
Interests
Research in the Lin group is focused on muscular dystrophy and mechanisms regulating muscle regeneration. His work has brought novel insights into the pathological mechanisms underlying some types of muscular dystrophy. The Lin group has established essential expertise in generation and differentiation of human induced pluripotent stem cells (iPSCs) and CRISPR-mediated genome manipulation technology. We are interested in integrating human iPSC and Organ-on-a-Chip technologies to enable neuromuscular research in health and disease, as well as drug discovery.Publications
Publications of specific relevance to Predictive in vitro Models2023
3D Compartmentalised Human Pluripotent Stem Cell–derived Neuromuscular Co-culturesHarley P, Paredes-Redondo A, Grenci G, Viasnoff V, Lin Y-Y and Lieberam I
Bio-Protocol vol. 13 (5), e4624-e4624.
05-03-2023
2022
CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell modelMorera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J, Garren S, Liu P, Morgan JE, Muntoni F, Christoforou N, Owens J, Tinker A and Lin Y-Y
Neuromuscular Disorders
01-11-2022
Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophyChesshyre M, Ridout D, Hashimoto Y, Ookubo Y, Torelli S, Maresh K, Ricotti V, Abbott L, Gupta VA, Main M, Ferrari G, Kowala A, Lin Y, Tedesco FS, Scoto M, Baranello G, Manzur A, Aoki Y and Muntoni F
Journal of Cachexia Sarcopenia and Muscle, Wiley vol. 13 (2), 1360-1372.
26-01-2022
2021
Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma.Marino S
Nature Communications, Nature Research (Part of Springer Nature)
21-10-2021
Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological correctionsParedes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B, Yang F, Liu P, Marino S, Pourquié O, Muntoni F, Wang J, Lieberam I and Lin YY
Science Advances vol. 7 (37)
10-09-2021
2019
A new patient‐derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α‐dystroglycanKim J, Lana B, Torelli S, Ryan D, Catapano F, Ala P, Luft C, Stevens E, Konstantinidis E, Louzada S, Fu B, Paredes‐Redondo A, Chan AE, Yang F, Stemple DL, Liu P, Ketteler R, Selwood DL, Muntoni F and Lin Y
Embo Reports, Springer Nature vol. 20 (11)
30-09-2019
Human Induced Pluripotent Stem Cells: Challenges and Opportunities in Developing New Therapies for Muscular DystrophiesParedes‐Redondo A and Lin Y
In Encyclopedia of Life Sciences, Wiley 1-10.
20-03-2019
2016
220th ENMC workshop: Dystroglycan and the dystroglycanopathies Naarden, The Netherlands, 27–29 May 2016Bevan N, Bevan L, Brown S, van Bokhoven H, Campbell KP, Cirak S, Cisneros B, Colognato H, Hohenester E, Lefeber D, Liljedahl M, Lu Q, Seta N, Shcherbata H, Straub V, Winder S and LIN Y
21-12-2016
The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan additionPraissman JL, Willer T, Sheikh MO, Toi A, Chitayat D, Lin Y-Y, Lee H, Stalnaker SH, Wang S, Prabhakar PK, Nelson SF, Stemple DL, Moore SA, Moremen KW, Campbell KP and Wells L
Elife vol. 5
29-04-2016
2013
Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan.Carss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, van Scherpenzeel M, Moore SA, Messina S, Bertini E, Bönnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL and Hurles ME
Am J Hum Genet vol. 93 (1), 29-41.
11-07-2013
Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycanCarss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, Van Scherpenzeel M, Moore SA, Messina S, Bertini E, Bönnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL and Hurles ME
American Journal of Human Genetics vol. 93 (1), 29-41.
11-07-2013
Mutations in B3GALNT2 Cause Congenital Muscular Dystrophy and Hypoglycosylation of α-DystroglycanStevens E, Carss KJ, Cirak S, Foley R, Torelli S, Willer T, Tambunan DE, Yau S, Brodd L, Sewry CA, Feng L, Haliloglu G, Orhan D, Dobyns WB, Enns GM, Manning M, Krause A, Salih MA, Walsh CA, Hurles M, Campbell KP, Manzini MC, Stemple D, Lin Y-Y and Muntoni F
American Journal of Human Genetics vol. 92 (3), 354-365.
01-01-2013
Missense mutations in-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause WalkerWarburg syndromeBuysse K, Riemersma M, Powell G, van Reeuwijk J, Chitayat D, Roscioli T, Kamsteeg E-J, van den Elzen C, van Beusekom E, Blaser S, Babul-Hirji R, Halliday W, Wright GJ, Stemple DL, Lin Y-Y, Lefeber DJ and van Bokhoven H
Human Molecular Genetics vol. 22 (9), 1746-1754.
01-01-2013
2012
Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycanRoscioli T, Kamsteeg EJ, Buysse K, Maystadt I, Van Reeuwijk J, Van Den Elzen C, Van Beusekom E, Riemersma M, Pfundt R, Vissers LELM, Schraders M, Altunoglu U, Buckley MF, Brunner HG, Grisart B, Zhou H, Veltman JA, Gilissen C, Mancini GMS, Delrée P, Willemsen MA, Ramadža DP, Chitayat D, Bennett C, Sheridan E, Peeters EAJ, Tan-Sindhunata GMB, De Die-Smulders CE, Devriendt K and Kayserili H
Nature Genetics vol. 44 (5), 581-585.
01-05-2012
2011
Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies.Lin Y-Y, White RJ, Torelli S, Cirak S, Muntoni F and Stemple DL
Hum Mol Genet vol. 20 (9), 1763-1775.
01-05-2011
2009
Molecular dissection of Drosophila Prickle isoforms distinguishes their essential and overlapping roles in planar cell polarity.Lin Y-Y and Gubb D
Dev Biol vol. 325 (2), 386-399.
15-01-2009
Grants
Grants of specific relevance to Predictive in vitro ModelsUnravelling mechanisms of drug-induced myocarditis using immune-responsive human cardiovascular chipYung-Yao Lin and Julien Gautrot
£121,420 MRC Medical Research Council
01-10-2024 - 30-09-2028
Natalia Moreno Sierra NC3R Early Career Engagement AwardYung-Yao Lin
£10,000 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
01-02-2024 - 15-06-2024
Engineering Circadian Biology into Human Induced Pluripotent Stem Cell Organ-on-a-Chip modelsDavid Lee and Yung-Yao Lin
£201,874 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2022 - 31-01-2025
Engineering a human microphysiological platform for modelling soft tissue injury and regenerationYung-Yao Lin, Julien Gautrot and John Connelly
£100,000 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
06-01-2021 - 16-06-2021
3D bio-printing human pluripotent stem cell-derived skeletal muscle constructs for disease modellingYung-Yao Lin and John Connelly
£91,761 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research
01-11-2020 - 15-06-2024
Multimodal Comparative Study of Human iPSC-Derived and Primary Skeletal Muscle Progenitor CellsYung-Yao Lin and Charles Knowles
£1,125 King's College London (KCL)
01-07-2020 - 30-06-2021
A microphysiological human 3D neuromuscular platform for modelling DMD and assessing potential therapeuticsYung-Yao Lin
£18,720 Duchenne Parent Project
01-02-2020 - 31-08-2021
Assessing Regenerative Potential Of Myogenic Progenitors Derived From CRISPR-corrected Human IPSCsYung-Yao Lin
£25,320 Action Duchenne
01-10-2018 - 30-09-2019
Assessing regenerative potential of myogenic progenitors derived from CRISPR-corrected human iPSCsYung-Yao Lin
£185,865 Barts and the London Charity
02-04-2018 - 31-03-2023
CRISPR/Cas9 Engineered Human iPSC Models for Muscular Dystrophy ResearchYung-Yao Lin and Andrew Tinker
£490,000 Pfizer Global Pharmaceuticals
14-06-2017 - 31-12-2020