Dr Yung-Yao Lin
Senior Lecturer
Centre for Genomics and Child Health, Blizard Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
Faculty of Medicine and Dentistry, Queen Mary University of London
Research
Human induced pluripotent stem cells, CRISPR genome editing, Neuromuscular disorders, Disease modelling, Regenerative medicine, Tissue engineering
Interests
Research in the Lin group is focused on muscular dystrophy and mechanisms regulating muscle regeneration. His work has brought novel insights into the pathological mechanisms underlying some types of muscular dystrophy. The Lin group has established essential expertise in generation and differentiation of human induced pluripotent stem cells (iPSCs) and CRISPR-mediated genome manipulation technology. We are interested in integrating human iPSC and Organ-on-a-Chip technologies to enable neuromuscular research in health and disease, as well as drug discovery.Publications
Publications of specific relevance to Predictive in vitro Models2023
Harley P, Paredes-Redondo A, Grenci G, Viasnoff V, Lin Y-Y and Lieberam I (2023). 3D Compartmentalised Human Pluripotent Stem Cell–derived Neuromuscular Co-cultures. Bio-protocol vol. 13, (5) e4624-e4624. 2022
Morera C, Kim J, Paredes-Redondo A, Nobles M, Rybin D, Moccia R, Kowala A, Meng J, Garren S, Liu P, Morgan JE, Muntoni F, Christoforou N, Owens J, Tinker A and Lin Y-Y (2022). CRISPR-mediated correction of skeletal muscle Ca2+ handling in a novel DMD patient-derived pluripotent stem cell model. Neuromuscular Disorders 
Chesshyre M, Ridout D, Hashimoto Y, Ookubo Y, Torelli S, Maresh K, Ricotti V, Abbott L, Gupta VA, Main M, Ferrari G, Kowala A, Lin Y, Tedesco FS, Scoto M, Baranello G, Manzur A, Aoki Y and Muntoni F (2022). Investigating the role of dystrophin isoform deficiency in motor function in Duchenne muscular dystrophy. Wiley Journal of Cachexia Sarcopenia and Muscle vol. 13, (2) 1360-1372. 2021
Marino S (2021). Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC‐derived neural stem cells in glioblastoma. Nature Research (part of Springer Nature) Nature Communications Paredes-Redondo A, Harley P, Maniati E, Ryan D, Louzada S, Meng J, Kowala A, Fu B, Yang F, Liu P, Marino S, Pourquié O, Muntoni F, Wang J, Lieberam I and Lin YY (2021). Optogenetic modeling of human neuromuscular circuits in Duchenne muscular dystrophy with CRISPR and pharmacological corrections. Science Advances vol. 7, (37) 2019
Kim J, Lana B, Torelli S, Ryan D, Catapano F, Ala P, Luft C, Stevens E, Konstantinidis E, Louzada S, Fu B, Paredes‐Redondo A, Chan AE, Yang F, Stemple DL, Liu P, Ketteler R, Selwood DL, Muntoni F and Lin Y (2019). A new patient‐derived iPSC model for dystroglycanopathies validates a compound that increases glycosylation of α‐dystroglycan. Springer Nature EMBO Reports vol. 20, (11) Paredes‐Redondo A and Lin Y (2019). Human Induced Pluripotent Stem Cells: Challenges and Opportunities in Developing New Therapies for Muscular Dystrophies. Encyclopedia of Life Sciences Wiley 2016
Bevan N, Bevan L, Brown S, van Bokhoven H, Campbell KP, Cirak S, Cisneros B, Colognato H, Hohenester E, Lefeber D, Liljedahl M, Lu Q, Seta N, Shcherbata H, Straub V, Winder S and LIN Y (2016). 220th ENMC workshop: Dystroglycan and the dystroglycanopathies Naarden, The Netherlands, 27–29 May 2016. Praissman JL, Willer T, Sheikh MO, Toi A, Chitayat D, Lin Y-Y, Lee H, Stalnaker SH, Wang S, Prabhakar PK, Nelson SF, Stemple DL, Moore SA, Moremen KW, Campbell KP and Wells L (2016). The functional O-mannose glycan on α-dystroglycan contains a phospho-ribitol primed for matriglycan addition. eLife vol. 5, 2013
Carss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, van Scherpenzeel M, Moore SA, Messina S, Bertini E, Bönnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL and Hurles ME (2013). Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan. Am J Hum Genet vol. 93, (1) 29-41. Carss KJ, Stevens E, Foley AR, Cirak S, Riemersma M, Torelli S, Hoischen A, Willer T, Van Scherpenzeel M, Moore SA, Messina S, Bertini E, Bönnemann CG, Abdenur JE, Grosmann CM, Kesari A, Punetha J, Quinlivan R, Waddell LB, Young HK, Wraige E, Yau S, Brodd L, Feng L, Sewry C, MacArthur DG, North KN, Hoffman E, Stemple DL and Hurles ME (2013). Mutations in GDP-mannose pyrophosphorylase B cause congenital and limb-girdle muscular dystrophies associated with hypoglycosylation of α-dystroglycan. American Journal of Human Genetics vol. 93, (1) 29-41. Stevens E, Carss KJ, Cirak S, Foley R, Torelli S, Willer T, Tambunan DE, Yau S, Brodd L, Sewry CA, Feng L, Haliloglu G, Orhan D, Dobyns WB, Enns GM, Manning M, Krause A, Salih MA, Walsh CA, Hurles M, Campbell KP, Manzini MC, Stemple D, Lin Y-Y and Muntoni F (2013). Mutations in B3GALNT2 Cause Congenital Muscular Dystrophy and Hypoglycosylation of α-Dystroglycan. AMERICAN JOURNAL OF HUMAN GENETICS vol. 92, (3) 354-365. Buysse K, Riemersma M, Powell G, van Reeuwijk J, Chitayat D, Roscioli T, Kamsteeg E-J, van den Elzen C, van Beusekom E, Blaser S, Babul-Hirji R, Halliday W, Wright GJ, Stemple DL, Lin Y-Y, Lefeber DJ and van Bokhoven H (2013). Missense mutations in-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) cause WalkerWarburg syndrome. HUMAN MOLECULAR GENETICS vol. 22, (9) 1746-1754. 2012
Lin Y-Y (2012). Muscle diseases in the zebrafish. Neuromuscul Disord vol. 22, (8) 673-684. Roscioli T, Kamsteeg EJ, Buysse K, Maystadt I, Van Reeuwijk J, Van Den Elzen C, Van Beusekom E, Riemersma M, Pfundt R, Vissers LELM, Schraders M, Altunoglu U, Buckley MF, Brunner HG, Grisart B, Zhou H, Veltman JA, Gilissen C, Mancini GMS, Delrée P, Willemsen MA, Ramadža DP, Chitayat D, Bennett C, Sheridan E, Peeters EAJ, Tan-Sindhunata GMB, De Die-Smulders CE, Devriendt K and Kayserili H (2012). Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycan. Nature Genetics vol. 44, (5) 581-585. 2011
Lin Y-Y, White RJ, Torelli S, Cirak S, Muntoni F and Stemple DL (2011). Zebrafish Fukutin family proteins link the unfolded protein response with dystroglycanopathies. Hum Mol Genet vol. 20, (9) 1763-1775. 2009
Lin Y-Y and Gubb D (2009). Molecular dissection of Drosophila Prickle isoforms distinguishes their essential and overlapping roles in planar cell polarity. Dev Biol vol. 325, (2) 386-399. Grants
Grants of specific relevance to Predictive in vitro ModelsUnravelling mechanisms of drug-induced myocarditis using immune-responsive human cardiovascular chipYung-Yao Lin and Julien Gautrot
£121,420 MRC Medical Research Council (01-10-2024 - 30-09-2028)
Natalia Moreno Sierra NC3R Early Career Engagement AwardYung-Yao Lin
£10,000 NC3Rs National Center for the Replacement, Refinement and Reduction of Animals in Research (01-02-2024 - 15-06-2024)
