CN-Bio
The Centre for Predictive in vitro Models houses CN-Bio's multi-organ PhysioMimix® Organ-on-chip system which is ideally suited to investigating multi-organ interactions.
PhysioMimix Organ-chip Platform
CNBio's PhysioMimix system enables:
- the co-culturing of human cells to faithfully recreate human organs and tissues
- perfused scaffolds to promote 3D organ model formation
- compatibility with inserts for apical and basolateral tissue growth to recreate a biological barrier
- recirculating fluidic flow delivering biomechanical stimulus, oxygen, and nutrients
- adjustable inter- and intra-organ flow rates to enhance physiological relevance
- viability, function, and phenotype to be maintained over many weeks to enable longer-term chronic disease and dosing studies
- deep mechanistic insights via large sampling volume (up to 1 mL) and individual microtissue analysis
- modeling of the immune system via the inclusion of circulating and tissue-specific immune cells
