TissUse

TissUse HUMIMIC Chip Platform

TissUse is pioneering the field of multi-organ-chip technology, with its HUMIMIC platform offering an advanced and versatile solution for in vitro modelling of human organs. This platform provides a unique opportunity to replicate the complexities of human biology in a controlled, reproducible manner, making it invaluable for a wide range of applications in drug development, toxicity testing, and disease modelling.

The TissUse HUMIMIC platform stands out for its ability to integrate up to four organ models on a single chip, enabling the creation of interconnected multi-organ systems that closely mimic human physiology. The system supports a pulsatile nutrient flow driven by an on-chip micropump, ensuring that critical substances like metabolites and growth factors are not washed out, which helps to maintain a more accurate in vivo-like environment. This setup enables the continuous and dynamic culture of human tissue equivalents, offering a more realistic simulation of how different organs interact within the human body.

In addition to multi-organ systems, TissUse also provides single-organ chips, giving researchers the flexibility to focus on individual organs or specific biological processes. This flexibility allows for targeted studies and deeper insights into the behaviour of single organs, such as liver, heart, or kidney, in a controlled environment.

Key Strength of the TissUse Platform

One of the platform's key strengths is its ability to be fully microscopable. Researchers can monitor cell behaviour and tissue morphology in real time, which is essential for dynamic studies and continuous analysis of organ functions. The system also allows for the easy sampling of media, enabling daily analysis of metabolites and providing valuable insights into ongoing biochemical processes. This sampling capability supports detailed kinetic studies, giving researchers a deeper understanding of how tissues respond over time.

Moreover, the TissUse platform offers a large selection of organ models, providing great flexibility in creating customized multi-organ systems. These models range from common organs like liver, intestine, and skin to more specialised ones, such as neuronal tissue, cardiac tissue, and tumour models. This diverse portfolio makes it easier to tailor experiments to specific research needs and enables more comprehensive testing, such as ADME(T) (Absorption, Distribution, Metabolism, Excretion, and Toxicity) profiling, to evaluate the effects of compounds on multiple organs simultaneously. For more details, an assay table is available here.

TissUse is committed to providing high quality, reliable, and reproducible results. The platform is designed with user-friendliness in mind, ensuring that researchers can easily manipulate the system, set up experiments, and integrate the HUMIMIC technology into their labs. The company also offers ongoing support, making it a long-term partner for researchers seeking to develop cutting-edge in vitro models.

In summary, the TissUse HUMIMIC platform is a powerful tool for researchers looking to model complex human biology in vitro. Its ability to integrate multiple organ models, provide single-organ systems, coupled with its real-time monitoring capabilities, customizable design, and extensive organ model portfolio, makes it a highly flexible and reliable solution for a wide range of research applications.